CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	ContextFold		PPfold(seed)
MCC	0.728	>	0.716
Average MCC ± 95% Confidence Intervals	0.733 ± 0.055	<	0.749 ± 0.077
Sensitivity	0.712	>	0.652
Positive Predictive Value	0.745	<	0.787
Total TP	1337	>	1226
Total TN	1050089	<	1050327
Total FP	553	>	467
Total FP CONTRA	97	>	48
Total FP INCONS	361	>	283
Total FP COMP	95	<	136
Total FN	542	<	653
P-value	1.41743914454e-05

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Performance plots

Comparison of performance of ContextFold and PPfold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and PPfold(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for ContextFold and PPfold(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and PPfold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and PPfold(seed)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP	1337
Total TN	1050089
Total FP	553
Total FP CONTRA	97
Total FP INCONS	361
Total FP COMP	95
Total FN	542

Total Scores
MCC	0.728
Average MCC ± 95% Confidence Intervals	0.733 ± 0.055
Sensitivity	0.712
Positive Predictive Value	0.745
Nr of predictions	23

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.80	0.75	0.87	65	56541	19	1	9	9	22
RFA_00627	rne5 links to Rfam database...	0.76	0.71	0.81	62	56876	16	3	12	1	25
RFA_00628	rne5 links to Rfam database...	0.60	0.56	0.65	48	57217	28	3	23	2	38
RFA_00630	rne5 links to Rfam database...	0.62	0.60	0.65	52	56873	35	3	25	7	35
RFA_00805	RNAIII links to Rfam database...	0.60	0.53	0.68	80	133268	38	3	35	0	70
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.93	0.95	38	25160	18	0	2	16	3
RFA_00816	R2_retro_el links to Rfam database...	0.67	0.71	0.63	29	23174	22	13	4	5	12
RFA_00817	R2_retro_el links to Rfam database...	0.58	0.59	0.59	24	21904	17	5	12	0	17
RFA_00818	R2_retro_el links to Rfam database...	0.61	0.66	0.56	27	20253	29	10	11	8	14
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	15	0	1	14	2
SRP_00079	Plant_SRP links to Rfam database...	0.87	0.85	0.89	75	41821	17	0	9	8	13
SRP_00099	Plant_SRP links to Rfam database...	0.67	0.66	0.67	63	44756	31	7	24	0	32
SRP_00124	Metazoa_SRP links to Rfam database...	0.90	0.87	0.94	74	37049	9	0	5	4	11
SRP_00182	Plant_SRP links to Rfam database...	0.86	0.83	0.88	84	45961	11	2	9	0	17
SRP_00241	Plant_SRP links to Rfam database...	0.55	0.59	0.53	48	45965	44	14	29	1	34
SRP_00252	Metazoa_SRP links to Rfam database...	0.66	0.67	0.64	60	49047	36	6	28	2	29
SRP_00253	Metazoa_SRP links to Rfam database...	0.70	0.71	0.68	64	49361	32	6	24	2	26
SRP_00257	Metazoa_SRP links to Rfam database...	0.93	0.90	0.97	97	50940	7	0	3	4	11
SRP_00260	Metazoa_SRP links to Rfam database...	0.68	0.68	0.68	68	47795	34	5	27	2	32
SRP_00328	Metazoa_SRP links to Rfam database...	0.82	0.81	0.82	69	39537	17	4	11	2	16
SRP_00329	Metazoa_SRP links to Rfam database...	0.70	0.69	0.70	59	39819	28	3	22	3	26
SRP_00331	Metazoa_SRP links to Rfam database...	0.68	0.63	0.72	55	37599	24	1	20	3	32
SRP_00340	Metazoa_SRP links to Rfam database...	0.70	0.70	0.70	57	41247	26	8	16	2	25

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Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1226
Total TN	1050327
Total FP	467
Total FP CONTRA	48
Total FP INCONS	283
Total FP COMP	136
Total FN	653

Total Scores
MCC	0.716
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077
Sensitivity	0.652
Positive Predictive Value	0.787
Nr of predictions	23

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00805	RNAIII links to Rfam database...	0.46	0.21	1.00	32	133354	0	0	0	0	118
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

2. Individual counts for ContextFold [ download as .csv ]

Performance of PPfold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]