CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	ContextFold		RNASampler(20)
MCC	0.790	>	0.565
Average MCC ± 95% Confidence Intervals	0.780 ± 0.041	>	0.539 ± 0.043
Sensitivity	0.750	>	0.413
Positive Predictive Value	0.832	>	0.772
Total TP	5590	>	3079
Total TN	4279356	<	4282091
Total FP	1353	>	1146
Total FP CONTRA	264	>	258
Total FP INCONS	867	>	649
Total FP COMP	222	<	239
Total FN	1859	<	4370
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of ContextFold and RNASampler(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ContextFold and RNASampler(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for ContextFold and RNASampler(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for ContextFold and RNASampler(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ContextFold and RNASampler(20)).

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Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

Total Base Pair Counts
Total TP	5590
Total TN	4279356
Total FP	1353
Total FP CONTRA	264
Total FP INCONS	867
Total FP COMP	222
Total FN	1859

Total Scores
MCC	0.790
Average MCC ± 95% Confidence Intervals	0.780 ± 0.041
Sensitivity	0.750
Positive Predictive Value	0.832
Nr of predictions	78

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2. Individual counts for ContextFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.95	0.91	1.00	81	45370	1	0	0	1	8
ASE_00090	RNaseP_bact_a links to Rfam database...	0.84	0.83	0.86	84	55513	14	1	13	0	17
ASE_00135	RNaseP_bact_a links to Rfam database...	0.95	0.91	0.99	99	63090	6	0	1	5	10
ASE_00153	RNaseP_nuc links to Rfam database...	0.51	0.51	0.51	37	57558	68	6	29	33	36
ASE_00215	RNaseP_bact_a links to Rfam database...	0.92	0.85	1.00	84	48432	1	0	0	1	15
ASE_00305	RNaseP_bact_b links to Rfam database...	0.93	0.89	0.96	76	54536	6	0	3	3	9
ASE_00328	RNaseP_bact_b links to Rfam database...	0.91	0.86	0.97	96	72672	9	0	3	6	16
ASE_00361	RNaseP_bact_a links to Rfam database...	0.94	0.88	1.00	112	75354	2	0	0	2	15
ASE_00427	RNaseP_nuc links to Rfam database...	0.00	0.00	0.00	0	40693	70	20	42	8	46
ASE_00441	RNaseP_bact_a links to Rfam database...	0.93	0.87	0.99	97	64163	4	0	1	3	15
SRP_00006	Metazoa_SRP links to Rfam database...	0.91	0.90	0.93	91	45655	7	0	7	0	10
SRP_00011	Plant_SRP links to Rfam database...	0.68	0.65	0.70	68	46263	29	1	28	0	36
SRP_00015	Plant_SRP links to Rfam database...	0.68	0.63	0.73	62	46275	26	0	23	3	37
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.92	0.90	0.94	78	37592	6	0	5	1	9
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.97	0.97	0.97	85	36768	6	0	3	3	3
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.87	0.85	0.88	75	36771	10	4	6	0	13
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.84	0.81	0.88	72	36233	11	5	5	1	17
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.75	0.72	0.79	63	36505	17	5	12	0	24
SRP_00050	Metazoa_SRP links to Rfam database...	0.98	0.96	1.00	95	44755	2	0	0	2	4
SRP_00066	Metazoa_SRP links to Rfam database...	0.97	0.96	0.98	96	45353	2	0	2	0	4
SRP_00086	Metazoa_SRP links to Rfam database...	0.94	0.91	0.98	91	44160	2	0	2	0	9
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.91	0.88	0.94	78	34108	5	1	4	0	11
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.97	0.93	1.00	84	35694	0	0	0	0	6
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.93	0.88	0.99	79	35431	3	0	1	2	11
SRP_00102	Metazoa_SRP links to Rfam database...	0.99	0.97	1.00	98	44453	0	0	0	0	3
SRP_00103	Metazoa_SRP links to Rfam database...	0.96	0.95	0.97	97	45351	3	1	2	0	5
SRP_00152	Plant_SRP links to Rfam database...	0.91	0.87	0.95	90	45658	6	0	5	1	13
SRP_00171	Metazoa_SRP links to Rfam database...	0.31	0.30	0.33	26	45372	53	7	46	0	62
SRP_00178	Plant_SRP links to Rfam database...	0.94	0.92	0.97	94	45656	3	0	3	0	8
SRP_00179	Plant_SRP links to Rfam database...	0.93	0.88	0.98	92	45962	5	0	2	3	13
SRP_00181	Plant_SRP links to Rfam database...	0.91	0.87	0.96	89	45963	4	0	4	0	13
SRP_00182	Plant_SRP links to Rfam database...	0.86	0.83	0.88	84	45961	11	2	9	0	17
SRP_00188	Plant_SRP links to Rfam database...	0.94	0.91	0.96	72	31050	4	0	3	1	7
SRP_00228	Metazoa_SRP links to Rfam database...	0.98	0.97	1.00	92	45359	4	0	0	4	3
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.97	0.97	0.98	83	36230	4	0	2	2	3
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.91	0.88	0.94	77	36233	7	0	5	2	11
SRP_00317	Metazoa_SRP links to Rfam database...	0.96	0.93	0.99	91	45058	3	0	1	2	7
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.30	0.41	0.23	16	35174	72	26	29	17	23
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.95	0.92	0.98	84	35425	4	0	2	2	7
SRP_00347	Metazoa_SRP links to Rfam database...	0.87	0.85	0.89	82	46573	11	2	8	1	14
SRP_00368	Metazoa_SRP links to Rfam database...	0.97	0.97	0.98	95	43859	2	0	2	0	3
TMR_00017	tmRNA links to Rfam database...	0.84	0.76	0.93	78	67077	6	2	4	0	24
TMR_00018	tmRNA links to Rfam database...	0.77	0.73	0.82	67	64538	15	7	8	0	25
TMR_00042	tmRNA links to Rfam database...	0.54	0.47	0.62	46	62761	31	4	24	3	52
TMR_00046	tmRNA links to Rfam database...	0.54	0.51	0.58	49	62750	39	6	30	3	47
TMR_00048	tmRNA links to Rfam database...	0.52	0.48	0.55	46	64897	44	5	32	7	49
TMR_00080	tmRNA links to Rfam database...	0.60	0.59	0.61	57	70407	37	8	28	1	39
TMR_00082	tmRNA links to Rfam database...	0.70	0.64	0.77	61	67817	20	7	11	2	35
TMR_00123	tmRNA links to Rfam database...	0.88	0.79	0.99	80	66349	1	1	0	0	21
TMR_00137	tmRNA links to Rfam database...	0.75	0.66	0.86	59	61006	13	1	9	3	30
TMR_00142	tmRNA links to Rfam database...	0.57	0.52	0.63	53	70792	41	6	25	10	49
TMR_00207	tmRNA links to Rfam database...	0.75	0.68	0.83	70	72306	15	2	12	1	33
TMR_00257	tmRNA links to Rfam database...	0.78	0.70	0.86	69	67081	11	1	10	0	29
TMR_00271	tmRNA links to Rfam database...	0.66	0.62	0.71	56	64182	27	6	17	4	35
TMR_00332	tmRNA links to Rfam database...	0.78	0.70	0.88	69	67083	10	2	7	1	30
TMR_00366	tmRNA links to Rfam database...	0.51	0.48	0.54	48	67807	51	15	26	10	52
TMR_00378	tmRNA links to Rfam database...	0.52	0.49	0.55	48	67809	45	13	26	6	49
TMR_00404	tmRNA links to Rfam database...	0.70	0.70	0.70	64	67437	40	9	18	13	28
TMR_00427	tmRNA links to Rfam database...	0.70	0.66	0.74	64	67442	25	8	14	3	33
TMR_00443	tmRNA links to Rfam database...	0.87	0.77	0.99	80	67080	1	1	0	0	24
TMR_00451	tmRNA links to Rfam database...	0.69	0.62	0.77	55	63475	16	5	11	0	34
TMR_00458	tmRNA links to Rfam database...	0.73	0.68	0.79	63	63466	18	2	15	1	30
TMR_00469	tmRNA links to Rfam database...	0.79	0.74	0.84	74	64532	14	9	5	0	26
TMR_00472	tmRNA links to Rfam database...	0.72	0.67	0.77	65	64536	23	7	12	4	32
TMR_00519	tmRNA links to Rfam database...	0.72	0.65	0.79	62	63112	19	2	14	3	33
TMR_00520	tmRNA links to Rfam database...	0.72	0.67	0.78	66	63105	28	0	19	9	33
TMR_00522	tmRNA links to Rfam database...	0.64	0.61	0.67	59	63102	37	3	26	8	38
TMR_00528	tmRNA links to Rfam database...	0.77	0.70	0.85	68	63110	12	6	6	0	29
TMR_00540	tmRNA links to Rfam database...	0.74	0.67	0.80	70	73449	19	6	11	2	34
TMR_00568	tmRNA links to Rfam database...	0.69	0.63	0.76	62	60644	22	2	18	2	37
TMR_00571	tmRNA links to Rfam database...	0.61	0.57	0.66	56	60641	35	2	27	6	43
TMR_00580	tmRNA links to Rfam database...	0.68	0.65	0.71	65	60635	29	7	19	3	35
TMR_00584	tmRNA links to Rfam database...	0.80	0.73	0.88	71	60994	14	4	6	4	26
TMR_00586	tmRNA links to Rfam database...	0.68	0.64	0.73	62	60990	26	8	15	3	35
TMR_00616	tmRNA links to Rfam database...	0.63	0.62	0.65	61	67067	34	8	25	1	38
TMR_00699	tmRNA links to Rfam database...	0.80	0.75	0.85	76	67072	13	3	10	0	26
TMR_00702	tmRNA links to Rfam database...	0.77	0.71	0.84	71	67076	14	4	10	0	29
TMR_00703	tmRNA links to Rfam database...	0.84	0.76	0.94	75	67448	5	1	4	0	24

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Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	3079
Total TN	4282091
Total FP	1146
Total FP CONTRA	258
Total FP INCONS	649
Total FP COMP	239
Total FN	4370

Total Scores
MCC	0.565
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043
Sensitivity	0.413
Positive Predictive Value	0.772
Nr of predictions	78

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of ContextFold - scored higher in this pairwise comparison

1. Total counts & total scores for ContextFold

2. Individual counts for ContextFold [ download as .csv ]

Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]