Table of contents:
- Overview
- Performance Plots
- Performance of HotKnots
- scored higher in this pairwise comparison
- Performance of CentroidHomfold‑LAST
- scored lower in this pairwise comparison
- Compile and download dataset for HotKnots & CentroidHomfold‑LAST [.zip] - may take several seconds...
Overview
| Metric |
HotKnots |
|
CentroidHomfold‑LAST |
|---|
| MCC |
0.640 |
>
|
0.232 |
| Average MCC ± 95% Confidence Intervals |
0.640
±
|
>
|
0.232
±
|
| Sensitivity |
0.615 |
>
|
0.154 |
| Positive Predictive Value |
0.667 |
>
|
0.353 |
| Total TP |
24 |
>
|
6 |
| Total TN |
21909 |
<
|
21928 |
| Total FP |
25 |
>
|
16 |
| Total FP CONTRA |
3 |
>
|
1 |
| Total FP INCONS |
9 |
<
|
10 |
| Total FP COMP |
13 |
>
|
5 |
| Total FN |
15 |
<
|
33 |
| P-value |
0.0 |
Performance plots
-
Comparison of performance of HotKnots and CentroidHomfold-LAST. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data
(individual counts for HotKnots
and CentroidHomfold‑LAST).
-
Comparison of average Matthews Correlation Coefficients (MCCs) for HotKnots and CentroidHomfold-LAST. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data
(individual counts for HotKnots
and CentroidHomfold‑LAST).
Performance of HotKnots
- scored higher in this pairwise comparison
1. Total counts & total scores for HotKnots
| Total Base Pair Counts |
|---|
| Total TP |
24 |
| Total TN |
21909 |
| Total FP |
25 |
| Total FP CONTRA |
3 |
| Total FP INCONS |
9 |
| Total FP COMP |
13 |
| Total FN |
15 |
| Total Scores |
|---|
| MCC |
0.640 |
| Average MCC ± 95% Confidence Intervals |
0.640
±
|
| Sensitivity |
0.615 |
| Positive Predictive Value |
0.667 |
| Nr of predictions |
1 |
Performance of CentroidHomfold‑LAST
- scored lower in this pairwise comparison
1. Total counts & total scores for CentroidHomfold‑LAST
| Total Base Pair Counts |
|---|
| Total TP |
6 |
| Total TN |
21928 |
| Total FP |
16 |
| Total FP CONTRA |
1 |
| Total FP INCONS |
10 |
| Total FP COMP |
5 |
| Total FN |
33 |
| Total Scores |
|---|
| MCC |
0.232 |
| Average MCC ± 95% Confidence Intervals |
0.232
±
|
| Sensitivity |
0.154 |
| Positive Predictive Value |
0.353 |
| Nr of predictions |
1 |
Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based
on the paper by Gardener & Giegerich, 2004.
| 
