CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	IPknot		CMfinder(seed)
MCC	0.725	>	0.454
Average MCC ± 95% Confidence Intervals	0.710 ± 0.054	>	0.456 ± 0.042
Sensitivity	0.696	>	0.271
Positive Predictive Value	0.756	<	0.762
Total TP	3204	>	1249
Total TN	2620454	<	2623051
Total FP	1314	>	419
Total FP CONTRA	219	>	30
Total FP INCONS	813	>	360
Total FP COMP	282	>	29
Total FN	1399	<	3354
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of IPknot and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for IPknot and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for IPknot and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for IPknot and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for IPknot and CMfinder(seed)).

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Performance of IPknot - scored higher in this pairwise comparison

1. Total counts & total scores for IPknot

Total Base Pair Counts
Total TP	3204
Total TN	2620454
Total FP	1314
Total FP CONTRA	219
Total FP INCONS	813
Total FP COMP	282
Total FN	1399

Total Scores
MCC	0.725
Average MCC ± 95% Confidence Intervals	0.710 ± 0.054
Sensitivity	0.696
Positive Predictive Value	0.756
Nr of predictions	51

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2. Individual counts for IPknot [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.33	0.26	0.42	30	103669	55	7	34	14	85
CRW_00016	Intron_gpI links to Rfam database...	0.75	0.67	0.83	80	77325	26	6	10	10	40
CRW_00610	Intron_gpI links to Rfam database...	0.61	0.54	0.68	44	36250	21	6	15	0	37
CRW_00613	Intron_gpI links to Rfam database...	0.86	0.78	0.94	61	34915	13	1	3	9	17
CRW_00614	Intron_gpI links to Rfam database...	0.13	0.14	0.13	8	121707	95	15	41	39	49
CRW_00618	Intron_gpI links to Rfam database...	0.25	0.25	0.26	15	56223	56	5	37	14	46
CRW_00633	Intron_gpI links to Rfam database...	0.64	0.58	0.72	61	63461	25	5	19	1	45
CRW_00634	Intron_gpI links to Rfam database...	0.60	0.56	0.65	53	64538	30	10	19	1	41
CRW_00670	Intron_gpI links to Rfam database...	0.83	0.78	0.87	94	70017	14	6	8	0	26
CRW_00671	Intron_gpI links to Rfam database...	0.82	0.74	0.92	86	62742	8	1	6	1	31
CRW_00672	Intron_gpI links to Rfam database...	0.76	0.72	0.80	80	72290	24	8	12	4	31
CRW_00674	Intron_gpI links to Rfam database...	0.75	0.69	0.83	85	83333	20	7	11	2	39
CRW_00676	Intron_gpI links to Rfam database...	0.47	0.44	0.51	51	93428	52	14	35	3	64
CRW_00692	Intron_gpI links to Rfam database...	0.56	0.47	0.68	42	68573	21	7	13	1	48
PDB_00827	Intron_gpI links to Rfam database...	0.79	0.65	0.95	53	26972	5	0	3	2	28
RFA_00606	Telomerase-cil links to Rfam database...	0.69	0.67	0.72	26	21285	20	7	3	10	13
RFA_00620	Telomerase-cil links to Rfam database...	0.60	0.59	0.61	23	21907	28	1	14	13	16
RFA_00626	rne5 links to Rfam database...	0.89	0.85	0.94	74	56537	14	0	5	9	13
RFA_00627	rne5 links to Rfam database...	0.69	0.66	0.73	57	56875	35	4	17	14	30
RFA_00628	rne5 links to Rfam database...	0.95	0.90	1.00	77	57214	14	0	0	14	9
RFA_00630	rne5 links to Rfam database...	0.82	0.75	0.89	65	56880	14	0	8	6	22
RFA_00639	7SK links to Rfam database...	0.46	0.45	0.48	39	54533	46	8	35	3	48
RFA_00814	R2_retro_el links to Rfam database...	0.89	0.88	0.90	36	25160	11	0	4	7	5
RFA_00815	R2_retro_el links to Rfam database...	0.57	0.61	0.54	25	24485	28	5	16	7	16
RFA_00816	R2_retro_el links to Rfam database...	0.82	0.85	0.80	35	23176	12	8	1	3	6
RFA_00817	R2_retro_el links to Rfam database...	0.23	0.24	0.22	10	21900	38	11	24	3	31
RFA_00818	R2_retro_el links to Rfam database...	0.69	0.68	0.70	28	20261	15	9	3	3	13
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	26	0	1	25	2
SRP_00016	Archaea_SRP links to Rfam database...	0.94	0.93	0.95	101	47789	7	0	5	2	8
SRP_00130	Archaea_SRP links to Rfam database...	0.67	0.67	0.67	65	49673	37	4	28	5	32
SRP_00142	Archaea_SRP links to Rfam database...	0.44	0.44	0.45	41	45965	52	7	43	2	52
SRP_00143	Archaea_SRP links to Rfam database...	0.73	0.73	0.73	74	49669	33	1	26	6	27
SRP_00144	Archaea_SRP links to Rfam database...	0.76	0.73	0.78	69	46577	26	1	18	7	25
SRP_00197	Archaea_SRP links to Rfam database...	0.68	0.57	0.82	58	49384	13	4	9	0	43
SRP_00198	Archaea_SRP links to Rfam database...	0.57	0.54	0.60	56	50946	39	6	32	1	47
SRP_00199	Archaea_SRP links to Rfam database...	0.69	0.65	0.73	68	50947	26	1	24	1	37
SRP_00201	Archaea_SRP links to Rfam database...	0.91	0.91	0.91	101	47784	12	4	6	2	10
SRP_00202	Archaea_SRP links to Rfam database...	0.97	0.96	0.97	112	54170	4	0	3	1	5
SRP_00203	Archaea_SRP links to Rfam database...	0.81	0.82	0.80	86	48720	30	1	21	8	19
SRP_00204	Archaea_SRP links to Rfam database...	0.78	0.76	0.80	78	49043	21	5	15	1	24
SRP_00206	Archaea_SRP links to Rfam database...	0.88	0.85	0.90	92	47793	11	5	5	1	16
SRP_00208	Archaea_SRP links to Rfam database...	0.85	0.84	0.87	85	46567	15	3	10	2	16
SRP_00255	Archaea_SRP links to Rfam database...	0.70	0.69	0.71	65	47495	29	1	25	3	29
SRP_00276	Archaea_SRP links to Rfam database...	0.94	0.95	0.93	104	50609	9	5	3	1	6
SRP_00278	Archaea_SRP links to Rfam database...	0.74	0.72	0.75	76	45955	27	3	22	2	29
SRP_00321	Archaea_SRP links to Rfam database...	0.77	0.77	0.77	83	47478	27	2	23	2	25
SRP_00322	Archaea_SRP links to Rfam database...	0.85	0.87	0.83	95	48402	21	4	15	2	14
SRP_00323	Archaea_SRP links to Rfam database...	0.91	0.90	0.91	96	47173	12	0	9	3	11
SRP_00330	Archaea_SRP links to Rfam database...	0.60	0.62	0.57	59	49983	50	4	40	6	36
SRP_00332	Archaea_SRP links to Rfam database...	0.92	0.92	0.92	98	50296	10	2	7	1	8
SRP_00339	Archaea_SRP links to Rfam database...	0.68	0.69	0.67	65	44454	37	5	27	5	29

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of IPknot - scored higher in this pairwise comparison

1. Total counts & total scores for IPknot

2. Individual counts for IPknot [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]