CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	MXScarna(20)		RNASampler(20)
MCC	0.646	>	0.565
Average MCC ± 95% Confidence Intervals	0.644 ± 0.040	>	0.539 ± 0.043
Sensitivity	0.607	>	0.413
Positive Predictive Value	0.690	<	0.772
Total TP	4519	>	3079
Total TN	4279524	<	4282091
Total FP	2613	>	1146
Total FP CONTRA	514	>	258
Total FP INCONS	1520	>	649
Total FP COMP	579	>	239
Total FN	2930	<	4370
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of MXScarna(20) and RNASampler(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(20) and RNASampler(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(20) and RNASampler(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(20) and RNASampler(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(20) and RNASampler(20)).

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Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

Total Base Pair Counts
Total TP	4519
Total TN	4279524
Total FP	2613
Total FP CONTRA	514
Total FP INCONS	1520
Total FP COMP	579
Total FN	2930

Total Scores
MCC	0.646
Average MCC ± 95% Confidence Intervals	0.644 ± 0.040
Sensitivity	0.607
Positive Predictive Value	0.690
Nr of predictions	78

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2. Individual counts for MXScarna(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.70	0.60	0.83	53	45387	22	1	10	11	36
ASE_00090	RNaseP_bact_a links to Rfam database...	0.58	0.50	0.68	50	55538	27	1	22	4	51
ASE_00135	RNaseP_bact_a links to Rfam database...	0.44	0.35	0.56	38	63122	41	1	29	11	71
ASE_00153	RNaseP_nuc links to Rfam database...	0.52	0.45	0.60	33	57575	51	2	20	29	40
ASE_00215	RNaseP_bact_a links to Rfam database...	0.24	0.19	0.30	19	48453	48	6	38	4	80
ASE_00305	RNaseP_bact_b links to Rfam database...	0.70	0.65	0.75	55	54542	29	4	14	11	30
ASE_00328	RNaseP_bact_b links to Rfam database...	0.71	0.66	0.77	74	72675	33	5	17	11	38
ASE_00361	RNaseP_bact_a links to Rfam database...	0.56	0.41	0.78	52	75399	19	1	14	4	75
ASE_00427	RNaseP_nuc links to Rfam database...	0.47	0.43	0.50	20	40715	47	3	17	27	26
ASE_00441	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	38	64196	33	1	26	6	74
SRP_00006	Metazoa_SRP links to Rfam database...	0.61	0.59	0.62	60	45656	43	0	37	6	41
SRP_00011	Plant_SRP links to Rfam database...	0.78	0.75	0.81	78	46264	28	0	18	10	26
SRP_00015	Plant_SRP links to Rfam database...	0.91	0.88	0.95	87	46268	20	0	5	15	12
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.82	0.76	0.88	66	37600	13	0	9	4	21
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.81	0.74	0.89	65	36783	17	0	8	9	23
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.83	0.77	0.89	68	36780	11	0	8	3	20
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.83	0.76	0.89	68	36239	11	0	8	3	21
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.76	0.74	0.78	64	36503	24	3	15	6	23
SRP_00050	Metazoa_SRP links to Rfam database...	0.91	0.89	0.93	88	44755	18	0	7	11	11
SRP_00066	Metazoa_SRP links to Rfam database...	0.82	0.79	0.86	79	45359	22	0	13	9	21
SRP_00086	Metazoa_SRP links to Rfam database...	0.91	0.91	0.92	91	44154	17	0	8	9	9
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.82	0.74	0.92	66	34119	9	0	6	3	23
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.80	0.73	0.88	66	35703	14	1	8	5	24
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.76	0.68	0.86	61	35440	14	1	9	4	29
SRP_00102	Metazoa_SRP links to Rfam database...	0.90	0.88	0.93	89	44455	15	0	7	8	12
SRP_00103	Metazoa_SRP links to Rfam database...	0.96	0.94	0.97	96	45352	12	0	3	9	6
SRP_00152	Plant_SRP links to Rfam database...	0.88	0.85	0.91	88	45656	20	1	8	11	15
SRP_00171	Metazoa_SRP links to Rfam database...	0.90	0.88	0.93	77	45368	24	0	6	18	11
SRP_00178	Plant_SRP links to Rfam database...	0.89	0.86	0.92	88	45657	16	0	8	8	14
SRP_00179	Plant_SRP links to Rfam database...	0.91	0.88	0.95	92	45959	17	0	5	12	13
SRP_00181	Plant_SRP links to Rfam database...	0.83	0.81	0.84	83	45957	24	0	16	8	19
SRP_00182	Plant_SRP links to Rfam database...	0.88	0.86	0.90	87	45959	19	0	10	9	14
SRP_00188	Plant_SRP links to Rfam database...	0.74	0.67	0.83	53	31061	16	1	10	5	26
SRP_00228	Metazoa_SRP links to Rfam database...	0.90	0.88	0.91	84	45359	21	0	8	13	11
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.74	0.71	0.78	61	36237	26	2	15	9	25
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.73	0.73	0.74	64	36228	33	3	20	10	24
SRP_00317	Metazoa_SRP links to Rfam database...	0.88	0.86	0.91	84	45058	21	0	8	13	14
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.54	0.44	0.68	17	35220	17	4	4	9	22
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.71	0.71	0.71	65	35420	30	3	23	4	26
SRP_00347	Metazoa_SRP links to Rfam database...	0.98	0.97	0.99	93	46571	15	0	1	14	3
SRP_00368	Metazoa_SRP links to Rfam database...	0.91	0.89	0.93	87	43862	20	0	7	13	11
TMR_00017	tmRNA links to Rfam database...	0.55	0.52	0.59	53	67071	42	16	21	5	49
TMR_00018	tmRNA links to Rfam database...	0.48	0.48	0.49	44	64530	48	21	25	2	48
TMR_00042	tmRNA links to Rfam database...	0.56	0.55	0.56	54	62739	48	11	31	6	44
TMR_00046	tmRNA links to Rfam database...	0.56	0.55	0.57	53	62742	46	5	35	6	43
TMR_00048	tmRNA links to Rfam database...	0.53	0.52	0.55	49	64891	48	7	33	8	46
TMR_00080	tmRNA links to Rfam database...	0.49	0.50	0.48	48	70399	54	25	28	1	48
TMR_00082	tmRNA links to Rfam database...	0.44	0.44	0.45	42	67803	53	17	34	2	54
TMR_00123	tmRNA links to Rfam database...	0.66	0.53	0.81	54	66363	23	2	11	10	47
TMR_00137	tmRNA links to Rfam database...	0.37	0.36	0.39	32	60992	53	18	33	2	57
TMR_00142	tmRNA links to Rfam database...	0.51	0.50	0.52	51	70778	53	14	33	6	51
TMR_00207	tmRNA links to Rfam database...	0.49	0.49	0.49	50	72288	54	16	36	2	53
TMR_00257	tmRNA links to Rfam database...	0.54	0.49	0.59	48	67080	38	10	23	5	50
TMR_00271	tmRNA links to Rfam database...	0.43	0.37	0.49	34	64192	38	11	24	3	57
TMR_00332	tmRNA links to Rfam database...	0.53	0.51	0.55	50	67070	43	15	26	2	49
TMR_00366	tmRNA links to Rfam database...	0.60	0.56	0.65	56	67810	43	8	22	13	44
TMR_00378	tmRNA links to Rfam database...	0.65	0.60	0.70	58	67813	36	10	15	11	39
TMR_00404	tmRNA links to Rfam database...	0.48	0.47	0.49	43	67441	54	14	30	10	49
TMR_00427	tmRNA links to Rfam database...	0.56	0.52	0.60	50	67445	36	15	18	3	47
TMR_00443	tmRNA links to Rfam database...	0.59	0.55	0.63	57	67070	36	15	19	2	47
TMR_00451	tmRNA links to Rfam database...	0.34	0.34	0.34	30	63459	58	21	36	1	59
TMR_00458	tmRNA links to Rfam database...	0.39	0.38	0.41	35	63460	51	20	31	0	58
TMR_00469	tmRNA links to Rfam database...	0.62	0.60	0.65	60	64527	38	14	19	5	40
TMR_00472	tmRNA links to Rfam database...	0.56	0.47	0.67	46	64551	34	12	11	11	51
TMR_00519	tmRNA links to Rfam database...	0.38	0.40	0.37	38	63086	68	19	47	2	57
TMR_00520	tmRNA links to Rfam database...	0.43	0.41	0.46	41	63100	51	12	37	2	58
TMR_00522	tmRNA links to Rfam database...	0.46	0.44	0.49	43	63102	45	17	28	0	54
TMR_00528	tmRNA links to Rfam database...	0.39	0.40	0.38	39	63088	65	19	44	2	58
TMR_00540	tmRNA links to Rfam database...	0.48	0.48	0.48	50	73431	56	17	38	1	54
TMR_00568	tmRNA links to Rfam database...	0.57	0.53	0.61	52	60641	45	4	29	12	47
TMR_00571	tmRNA links to Rfam database...	0.60	0.56	0.65	55	60641	42	5	25	12	44
TMR_00580	tmRNA links to Rfam database...	0.60	0.52	0.69	52	60651	33	3	20	10	48
TMR_00584	tmRNA links to Rfam database...	0.61	0.57	0.66	55	60992	39	5	23	11	42
TMR_00586	tmRNA links to Rfam database...	0.58	0.55	0.62	53	60989	42	6	27	9	44
TMR_00616	tmRNA links to Rfam database...	0.58	0.47	0.71	47	67095	24	9	10	5	52
TMR_00699	tmRNA links to Rfam database...	0.55	0.50	0.60	51	67076	37	10	24	3	51
TMR_00702	tmRNA links to Rfam database...	0.52	0.50	0.55	50	67070	43	14	27	2	50
TMR_00703	tmRNA links to Rfam database...	0.54	0.49	0.58	49	67444	39	13	22	4	50

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Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	3079
Total TN	4282091
Total FP	1146
Total FP CONTRA	258
Total FP INCONS	649
Total FP COMP	239
Total FN	4370

Total Scores
MCC	0.565
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043
Sensitivity	0.413
Positive Predictive Value	0.772
Nr of predictions	78

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of MXScarna(20) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(20)

2. Individual counts for MXScarna(20) [ download as .csv ]

Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]