CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	MXScarna(seed)		CMfinder(seed)
MCC	0.696	>	0.454
Average MCC ± 95% Confidence Intervals	0.650 ± 0.090	>	0.456 ± 0.042
Sensitivity	0.605	>	0.271
Positive Predictive Value	0.802	>	0.762
Total TP	2787	>	1249
Total TN	2621213	<	2623051
Total FP	1206	>	419
Total FP CONTRA	81	>	30
Total FP INCONS	609	>	360
Total FP COMP	516	>	29
Total FN	1816	<	3354
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of MXScarna(seed) and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and CMfinder(seed)).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP	2787
Total TN	2621213
Total FP	1206
Total FP CONTRA	81
Total FP INCONS	609
Total FP COMP	516
Total FN	1816

Total Scores
MCC	0.696
Average MCC ± 95% Confidence Intervals	0.650 ± 0.090
Sensitivity	0.605
Positive Predictive Value	0.802
Nr of predictions	51

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.33	0.21	0.53	24	103695	23	4	17	2	91
CRW_00016	Intron_gpI links to Rfam database...	0.31	0.19	0.51	23	77376	24	7	15	2	97
CRW_00610	Intron_gpI links to Rfam database...	0.16	0.09	0.32	7	36293	15	1	14	0	74
CRW_00613	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	34956	24	7	17	0	78
CRW_00614	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	121749	22	4	18	0	57
CRW_00618	Intron_gpI links to Rfam database...	0.18	0.10	0.32	6	56261	13	1	12	0	55
CRW_00633	Intron_gpI links to Rfam database...	0.45	0.27	0.74	29	63507	14	0	10	4	77
CRW_00634	Intron_gpI links to Rfam database...	0.47	0.30	0.74	28	64582	18	0	10	8	66
CRW_00670	Intron_gpI links to Rfam database...	0.47	0.26	0.86	31	70089	7	0	5	2	89
CRW_00671	Intron_gpI links to Rfam database...	0.56	0.37	0.84	43	62784	10	0	8	2	74
CRW_00672	Intron_gpI links to Rfam database...	0.43	0.28	0.67	31	72344	17	0	15	2	80
CRW_00674	Intron_gpI links to Rfam database...	0.22	0.14	0.37	17	83390	29	5	24	0	107
CRW_00676	Intron_gpI links to Rfam database...	0.03	0.02	0.07	2	93500	31	4	22	5	113
CRW_00692	Intron_gpI links to Rfam database...	0.03	0.01	0.06	1	68619	22	0	15	7	89
PDB_00827	Intron_gpI links to Rfam database...	0.00	0.00	0.00	0	27011	17	1	16	0	81
RFA_00606	Telomerase-cil links to Rfam database...	0.53	0.51	0.56	20	21285	25	4	12	9	19
RFA_00620	Telomerase-cil links to Rfam database...	0.20	0.18	0.23	7	21915	33	7	16	10	32
RFA_00626	rne5 links to Rfam database...	0.89	0.87	0.92	76	56533	29	2	5	22	11
RFA_00627	rne5 links to Rfam database...	0.83	0.79	0.87	69	56874	36	1	9	26	18
RFA_00628	rne5 links to Rfam database...	0.85	0.81	0.89	70	57212	38	2	7	29	16
RFA_00630	rne5 links to Rfam database...	0.82	0.78	0.86	68	56874	33	2	9	22	19
RFA_00639	7SK links to Rfam database...	0.31	0.31	0.31	27	54527	69	10	51	8	60
RFA_00814	R2_retro_el links to Rfam database...	0.95	0.93	0.97	38	25161	22	0	1	21	3
RFA_00815	R2_retro_el links to Rfam database...	0.96	0.93	1.00	38	24493	15	0	0	15	3
RFA_00816	R2_retro_el links to Rfam database...	0.96	0.93	1.00	38	23182	15	0	0	15	3
RFA_00817	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	21909	12	0	0	12	5
RFA_00818	R2_retro_el links to Rfam database...	0.64	0.68	0.61	28	20255	30	11	7	12	13
RFA_00819	R2_retro_el links to Rfam database...	0.94	0.90	0.97	37	27928	26	0	1	25	4
SRP_00016	Archaea_SRP links to Rfam database...	0.92	0.89	0.95	97	47793	15	0	5	10	12
SRP_00130	Archaea_SRP links to Rfam database...	0.74	0.70	0.77	68	49682	35	1	19	15	29
SRP_00142	Archaea_SRP links to Rfam database...	0.89	0.87	0.90	81	45966	25	0	9	16	12
SRP_00143	Archaea_SRP links to Rfam database...	0.84	0.83	0.85	84	49671	26	0	15	11	17
SRP_00144	Archaea_SRP links to Rfam database...	0.87	0.86	0.87	81	46572	28	0	12	16	13
SRP_00197	Archaea_SRP links to Rfam database...	0.92	0.90	0.94	91	49358	24	0	6	18	10
SRP_00198	Archaea_SRP links to Rfam database...	0.90	0.87	0.92	90	50942	24	0	8	16	13
SRP_00199	Archaea_SRP links to Rfam database...	0.89	0.88	0.91	92	50939	21	0	9	12	13
SRP_00201	Archaea_SRP links to Rfam database...	0.94	0.93	0.96	103	47788	11	0	4	7	8
SRP_00202	Archaea_SRP links to Rfam database...	0.89	0.85	0.93	100	54178	16	0	7	9	17
SRP_00203	Archaea_SRP links to Rfam database...	0.83	0.83	0.83	87	48723	25	0	18	7	18
SRP_00204	Archaea_SRP links to Rfam database...	0.87	0.85	0.88	87	49042	25	0	12	13	15
SRP_00206	Archaea_SRP links to Rfam database...	0.94	0.93	0.96	100	47791	14	0	4	10	8
SRP_00208	Archaea_SRP links to Rfam database...	0.91	0.88	0.95	89	46571	20	0	5	15	12
SRP_00255	Archaea_SRP links to Rfam database...	0.74	0.76	0.73	71	47489	40	1	25	14	23
SRP_00276	Archaea_SRP links to Rfam database...	0.93	0.91	0.94	100	50615	13	0	6	7	10
SRP_00278	Archaea_SRP links to Rfam database...	0.73	0.69	0.77	72	45963	26	0	21	5	33
SRP_00321	Archaea_SRP links to Rfam database...	0.76	0.75	0.78	81	47482	30	0	23	7	27
SRP_00322	Archaea_SRP links to Rfam database...	0.79	0.75	0.83	82	48417	26	0	17	9	27
SRP_00323	Archaea_SRP links to Rfam database...	0.85	0.83	0.87	89	47176	22	0	13	9	18
SRP_00330	Archaea_SRP links to Rfam database...	0.80	0.80	0.81	76	49992	29	2	16	11	19
SRP_00332	Archaea_SRP links to Rfam database...	0.95	0.93	0.97	99	50301	15	0	3	12	7
SRP_00339	Archaea_SRP links to Rfam database...	0.78	0.78	0.78	73	44458	27	4	16	7	21

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

2. Individual counts for MXScarna(seed) [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]