CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	MXScarna(seed)		Murlet(seed)
MCC	0.742	>	0.569
Average MCC ± 95% Confidence Intervals	0.739 ± 0.072	>	0.550 ± 0.089
Sensitivity	0.721	>	0.383
Positive Predictive Value	0.765	<	0.845
Total TP	1881	>	1000
Total TN	1502973	<	1504247
Total FP	1031	>	241
Total FP CONTRA	78	>	15
Total FP INCONS	499	>	169
Total FP COMP	454	>	57
Total FN	727	<	1608
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of MXScarna(seed) and Murlet(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and Murlet(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and Murlet(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and Murlet(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and Murlet(seed)).

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Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP	1881
Total TN	1502973
Total FP	1031
Total FP CONTRA	78
Total FP INCONS	499
Total FP COMP	454
Total FN	727

Total Scores
MCC	0.742
Average MCC ± 95% Confidence Intervals	0.739 ± 0.072
Sensitivity	0.721
Positive Predictive Value	0.765
Nr of predictions	31

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2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.53	0.51	0.56	20	21285	25	4	12	9	19
RFA_00620	Telomerase-cil links to Rfam database...	0.20	0.18	0.23	7	21915	33	7	16	10	32
RFA_00626	rne5 links to Rfam database...	0.89	0.87	0.92	76	56533	29	2	5	22	11
RFA_00627	rne5 links to Rfam database...	0.83	0.79	0.87	69	56874	36	1	9	26	18
RFA_00628	rne5 links to Rfam database...	0.85	0.81	0.89	70	57212	38	2	7	29	16
RFA_00630	rne5 links to Rfam database...	0.82	0.78	0.86	68	56874	33	2	9	22	19
RFA_00639	7SK links to Rfam database...	0.31	0.31	0.31	27	54527	69	10	51	8	60
RFA_00814	R2_retro_el links to Rfam database...	0.95	0.93	0.97	38	25161	22	0	1	21	3
RFA_00815	R2_retro_el links to Rfam database...	0.96	0.93	1.00	38	24493	15	0	0	15	3
RFA_00816	R2_retro_el links to Rfam database...	0.96	0.93	1.00	38	23182	15	0	0	15	3
RFA_00817	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	21909	12	0	0	12	5
RFA_00818	R2_retro_el links to Rfam database...	0.64	0.68	0.61	28	20255	30	11	7	12	13
RFA_00819	R2_retro_el links to Rfam database...	0.94	0.90	0.97	37	27928	26	0	1	25	4
RFA_00820	bicoid_3 links to Rfam database...	0.88	0.88	0.87	141	151363	51	0	21	30	19
RFA_00830	bicoid_3 links to Rfam database...	0.61	0.59	0.63	91	152484	92	2	51	39	63
SRP_00079	Plant_SRP links to Rfam database...	0.68	0.66	0.71	58	41823	39	0	24	15	30
SRP_00124	Metazoa_SRP links to Rfam database...	0.60	0.55	0.64	47	37055	30	6	20	4	38
SRP_00182	Plant_SRP links to Rfam database...	0.84	0.83	0.85	84	45957	25	0	15	10	17
SRP_00197	Archaea_SRP links to Rfam database...	0.92	0.90	0.94	91	49358	24	0	6	18	10
SRP_00198	Archaea_SRP links to Rfam database...	0.90	0.87	0.92	90	50942	24	0	8	16	13
SRP_00199	Archaea_SRP links to Rfam database...	0.89	0.88	0.91	92	50939	21	0	9	12	13
SRP_00202	Archaea_SRP links to Rfam database...	0.89	0.85	0.93	100	54178	16	0	7	9	17
SRP_00241	Plant_SRP links to Rfam database...	0.50	0.51	0.49	42	45970	54	8	36	10	40
SRP_00255	Archaea_SRP links to Rfam database...	0.74	0.76	0.73	71	47489	40	1	25	14	23
SRP_00260	Metazoa_SRP links to Rfam database...	0.50	0.47	0.53	47	47806	44	6	36	2	53
SRP_00278	Archaea_SRP links to Rfam database...	0.73	0.69	0.77	72	45963	26	0	21	5	33
SRP_00322	Archaea_SRP links to Rfam database...	0.79	0.75	0.83	82	48417	26	0	17	9	27
SRP_00328	Metazoa_SRP links to Rfam database...	0.64	0.60	0.69	51	39547	31	4	19	8	34
SRP_00329	Metazoa_SRP links to Rfam database...	0.63	0.60	0.65	51	39825	35	4	23	8	34
SRP_00339	Archaea_SRP links to Rfam database...	0.78	0.78	0.78	73	44458	27	4	16	7	21
SRP_00340	Metazoa_SRP links to Rfam database...	0.58	0.56	0.60	46	41251	43	4	27	12	36

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Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP	1000
Total TN	1504247
Total FP	241
Total FP CONTRA	15
Total FP INCONS	169
Total FP COMP	57
Total FN	1608

Total Scores
MCC	0.569
Average MCC ± 95% Confidence Intervals	0.550 ± 0.089
Sensitivity	0.383
Positive Predictive Value	0.845
Nr of predictions	31

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21321	0	0	0	0	39
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21945	0	0	0	0	39
RFA_00626	rne5 links to Rfam database...	0.81	0.66	1.00	57	56559	4	0	0	4	30
RFA_00627	rne5 links to Rfam database...	0.84	0.70	1.00	61	56892	5	0	0	5	26
RFA_00628	rne5 links to Rfam database...	0.83	0.69	1.00	59	57232	8	0	0	8	27
RFA_00630	rne5 links to Rfam database...	0.82	0.67	1.00	58	56895	4	0	0	4	29
RFA_00639	7SK links to Rfam database...	0.21	0.11	0.40	10	54590	15	4	11	0	77
RFA_00814	R2_retro_el links to Rfam database...	0.75	0.63	0.90	26	25171	4	0	3	1	15
RFA_00815	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	24503	1	0	0	1	13
RFA_00816	R2_retro_el links to Rfam database...	0.75	0.63	0.90	26	23191	4	0	3	1	15
RFA_00817	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	21917	1	0	0	1	13
RFA_00818	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	20273	1	0	0	1	13
RFA_00819	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	27938	0	0	0	0	13
RFA_00820	bicoid_3 links to Rfam database...	0.71	0.56	0.89	90	151424	13	3	8	2	70
RFA_00830	bicoid_3 links to Rfam database...	0.59	0.45	0.78	70	152538	23	3	17	3	84
SRP_00079	Plant_SRP links to Rfam database...	0.54	0.33	0.88	29	41872	6	0	4	2	59
SRP_00124	Metazoa_SRP links to Rfam database...	0.15	0.09	0.24	8	37094	27	3	23	1	77
SRP_00182	Plant_SRP links to Rfam database...	0.59	0.35	1.00	35	46021	1	0	0	1	66
SRP_00197	Archaea_SRP links to Rfam database...	0.47	0.28	0.80	28	49420	8	0	7	1	73
SRP_00198	Archaea_SRP links to Rfam database...	0.47	0.27	0.82	28	51006	7	0	6	1	75
SRP_00199	Archaea_SRP links to Rfam database...	0.47	0.24	0.93	25	51013	3	0	2	1	80
SRP_00202	Archaea_SRP links to Rfam database...	0.48	0.25	0.94	29	54254	2	0	2	0	88
SRP_00241	Plant_SRP links to Rfam database...	0.51	0.33	0.79	27	46022	9	0	7	2	55
SRP_00255	Archaea_SRP links to Rfam database...	0.65	0.43	1.00	40	47546	2	0	0	2	54
SRP_00260	Metazoa_SRP links to Rfam database...	0.21	0.14	0.33	14	47852	29	1	28	0	86
SRP_00278	Archaea_SRP links to Rfam database...	0.53	0.30	0.94	31	46023	3	0	2	1	74
SRP_00322	Archaea_SRP links to Rfam database...	0.44	0.25	0.79	27	48482	8	0	7	1	82
SRP_00328	Metazoa_SRP links to Rfam database...	0.49	0.34	0.71	29	39580	16	1	11	4	56
SRP_00329	Metazoa_SRP links to Rfam database...	0.50	0.34	0.73	29	39863	16	0	11	5	56
SRP_00339	Archaea_SRP links to Rfam database...	0.49	0.32	0.77	30	44512	9	0	9	0	64
SRP_00340	Metazoa_SRP links to Rfam database...	0.44	0.27	0.73	22	41298	12	0	8	4	60

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

2. Individual counts for MXScarna(seed) [ download as .csv ]

Performance of Murlet(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

2. Individual counts for Murlet(seed) [ download as .csv ]