CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

Home

Methods

Datasets

Rankings

RNA 2D Atlas

Help

FAQ

Contact us

RSS feeds

Twitter

Overview

Metric	MXScarna(seed)		RNASampler(20)
MCC	0.778	>	0.578
Average MCC ± 95% Confidence Intervals	0.765 ± 0.051	>	0.525 ± 0.079
Sensitivity	0.721	>	0.384
Positive Predictive Value	0.841	<	0.871
Total TP	2767	>	1475
Total TN	1858628	<	1860227
Total FP	880	>	283
Total FP CONTRA	56	>	28
Total FP INCONS	469	>	190
Total FP COMP	355	>	65
Total FN	1071	<	2363
P-value	3.56938820447e-08

^top

Performance plots

Comparison of performance of MXScarna(seed) and RNASampler(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MXScarna(seed) and RNASampler(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MXScarna(seed) and RNASampler(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for MXScarna(seed) and RNASampler(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MXScarna(seed) and RNASampler(20)).

^top

Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

Total Base Pair Counts
Total TP	2767
Total TN	1858628
Total FP	880
Total FP CONTRA	56
Total FP INCONS	469
Total FP COMP	355
Total FN	1071

Total Scores
MCC	0.778
Average MCC ± 95% Confidence Intervals	0.765 ± 0.051
Sensitivity	0.721
Positive Predictive Value	0.841
Nr of predictions	41

^top

2. Individual counts for MXScarna(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.82	0.71	0.94	63	45384	7	1	3	3	26
ASE_00090	RNaseP_bact_a links to Rfam database...	0.66	0.54	0.81	55	55543	16	2	11	3	46
ASE_00135	RNaseP_bact_a links to Rfam database...	0.40	0.32	0.51	35	63121	35	4	30	1	74
ASE_00153	RNaseP_nuc links to Rfam database...	0.60	0.48	0.76	35	57584	26	0	11	15	38
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.26	0.54	26	48468	23	2	20	1	73
ASE_00305	RNaseP_bact_b links to Rfam database...	0.73	0.68	0.77	58	54540	28	4	13	11	27
ASE_00328	RNaseP_bact_b links to Rfam database...	0.73	0.66	0.80	74	72679	31	5	13	13	38
ASE_00361	RNaseP_bact_a links to Rfam database...	0.66	0.46	0.94	59	75403	7	1	3	3	68
ASE_00427	RNaseP_nuc links to Rfam database...	0.56	0.41	0.76	19	40730	18	1	5	12	27
ASE_00441	RNaseP_bact_a links to Rfam database...	0.32	0.24	0.43	27	64198	40	4	32	4	85
SRP_00006	Metazoa_SRP links to Rfam database...	0.84	0.82	0.86	83	45657	22	0	13	9	18
SRP_00011	Plant_SRP links to Rfam database...	0.77	0.77	0.78	80	46257	31	0	23	8	24
SRP_00015	Plant_SRP links to Rfam database...	0.87	0.85	0.89	84	46266	25	0	10	15	15
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.81	0.75	0.88	65	37601	13	0	9	4	22
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.80	0.73	0.88	64	36783	15	0	9	6	24
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.84	0.78	0.91	69	36780	11	0	7	4	19
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.84	0.78	0.91	69	36239	11	0	7	4	20
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.84	0.77	0.92	67	36512	13	0	6	7	20
SRP_00050	Metazoa_SRP links to Rfam database...	0.92	0.91	0.94	90	44754	20	0	6	14	9
SRP_00066	Metazoa_SRP links to Rfam database...	0.85	0.83	0.86	83	45355	25	0	13	12	17
SRP_00086	Metazoa_SRP links to Rfam database...	0.91	0.90	0.93	90	44156	17	0	7	10	10
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.77	0.69	0.86	61	34120	13	1	9	3	28
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.80	0.73	0.88	66	35703	13	1	8	4	24
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.78	0.71	0.86	64	35437	14	1	9	4	26
SRP_00102	Metazoa_SRP links to Rfam database...	0.90	0.88	0.93	89	44455	16	0	7	9	12
SRP_00103	Metazoa_SRP links to Rfam database...	0.91	0.89	0.92	91	45352	17	0	8	9	11
SRP_00152	Plant_SRP links to Rfam database...	0.88	0.86	0.89	89	45653	21	0	11	10	14
SRP_00171	Metazoa_SRP links to Rfam database...	0.83	0.83	0.84	73	45364	36	0	14	22	15
SRP_00178	Plant_SRP links to Rfam database...	0.89	0.88	0.89	90	45652	23	0	11	12	12
SRP_00179	Plant_SRP links to Rfam database...	0.87	0.86	0.88	90	45954	23	0	12	11	15
SRP_00181	Plant_SRP links to Rfam database...	0.80	0.79	0.80	81	45955	30	0	20	10	21
SRP_00182	Plant_SRP links to Rfam database...	0.84	0.83	0.85	84	45957	25	0	15	10	17
SRP_00188	Plant_SRP links to Rfam database...	0.54	0.51	0.58	40	31056	32	7	22	3	39
SRP_00228	Metazoa_SRP links to Rfam database...	0.89	0.87	0.90	83	45359	23	0	9	14	12
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.84	0.76	0.93	65	36245	14	0	5	9	21
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.82	0.73	0.91	64	36245	15	0	6	9	24
SRP_00317	Metazoa_SRP links to Rfam database...	0.89	0.87	0.92	85	45058	22	0	7	15	13
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.35	0.44	0.29	17	35186	58	21	21	16	22
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.78	0.71	0.84	65	35434	14	1	11	2	26
SRP_00347	Metazoa_SRP links to Rfam database...	0.93	0.93	0.94	89	46570	18	0	6	12	7
SRP_00368	Metazoa_SRP links to Rfam database...	0.90	0.88	0.92	86	43863	19	0	7	12	12

^top

Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	1475
Total TN	1860227
Total FP	283
Total FP CONTRA	28
Total FP INCONS	190
Total FP COMP	65
Total FN	2363

Total Scores
MCC	0.578
Average MCC ± 95% Confidence Intervals	0.525 ± 0.079
Sensitivity	0.384
Positive Predictive Value	0.871
Nr of predictions	41

^top

2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40

^top

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of MXScarna(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for MXScarna(seed)

2. Individual counts for MXScarna(seed) [ download as .csv ]

Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]