CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	MaxExpect		CMfinder(seed)
MCC	0.596	>	0.454
Average MCC ± 95% Confidence Intervals	0.583 ± 0.060	>	0.456 ± 0.042
Sensitivity	0.592	>	0.271
Positive Predictive Value	0.601	<	0.762
Total TP	2727	>	1249
Total TN	2620151	<	2623051
Total FP	2191	>	419
Total FP CONTRA	311	>	30
Total FP INCONS	1501	>	360
Total FP COMP	379	>	29
Total FN	1876	<	3354
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of MaxExpect and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for MaxExpect and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for MaxExpect and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for MaxExpect and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for MaxExpect and CMfinder(seed)).

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Performance of MaxExpect - scored higher in this pairwise comparison

1. Total counts & total scores for MaxExpect

Total Base Pair Counts
Total TP	2727
Total TN	2620151
Total FP	2191
Total FP CONTRA	311
Total FP INCONS	1501
Total FP COMP	379
Total FN	1876

Total Scores
MCC	0.596
Average MCC ± 95% Confidence Intervals	0.583 ± 0.060
Sensitivity	0.592
Positive Predictive Value	0.601
Nr of predictions	51

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2. Individual counts for MaxExpect [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.42	0.37	0.47	43	103648	69	4	45	20	72
CRW_00016	Intron_gpI links to Rfam database...	0.51	0.47	0.57	56	77322	56	6	37	13	64
CRW_00610	Intron_gpI links to Rfam database...	0.46	0.46	0.47	37	36237	41	7	34	0	44
CRW_00613	Intron_gpI links to Rfam database...	0.85	0.82	0.89	64	34908	16	0	8	8	14
CRW_00614	Intron_gpI links to Rfam database...	0.14	0.16	0.12	9	121696	125	18	48	59	48
CRW_00618	Intron_gpI links to Rfam database...	0.19	0.20	0.19	12	56217	69	7	44	18	49
CRW_00633	Intron_gpI links to Rfam database...	0.62	0.57	0.67	60	63457	32	8	21	3	46
CRW_00634	Intron_gpI links to Rfam database...	0.48	0.47	0.49	44	64531	49	9	36	4	50
CRW_00670	Intron_gpI links to Rfam database...	0.56	0.58	0.56	69	70001	57	12	43	2	51
CRW_00671	Intron_gpI links to Rfam database...	0.80	0.76	0.85	89	62730	20	1	15	4	28
CRW_00672	Intron_gpI links to Rfam database...	0.78	0.77	0.78	86	72280	32	6	18	8	25
CRW_00674	Intron_gpI links to Rfam database...	0.63	0.61	0.64	76	83318	45	8	34	3	48
CRW_00676	Intron_gpI links to Rfam database...	0.60	0.60	0.60	69	93413	64	12	34	18	46
CRW_00692	Intron_gpI links to Rfam database...	0.33	0.34	0.32	31	68537	80	17	50	13	59
PDB_00827	Intron_gpI links to Rfam database...	0.77	0.65	0.91	53	26970	7	0	5	2	28
RFA_00606	Telomerase-cil links to Rfam database...	0.68	0.67	0.70	26	21284	24	7	4	13	13
RFA_00620	Telomerase-cil links to Rfam database...	0.44	0.49	0.40	19	21897	42	7	22	13	20
RFA_00626	rne5 links to Rfam database...	0.88	0.84	0.92	73	56537	23	2	4	17	14
RFA_00627	rne5 links to Rfam database...	0.71	0.68	0.74	59	56873	37	5	16	16	28
RFA_00628	rne5 links to Rfam database...	0.91	0.88	0.94	76	57210	25	0	5	20	10
RFA_00630	rne5 links to Rfam database...	0.66	0.66	0.66	57	56867	44	7	22	15	30
RFA_00639	7SK links to Rfam database...	0.49	0.51	0.48	44	54523	57	12	36	9	43
RFA_00814	R2_retro_el links to Rfam database...	0.24	0.27	0.22	11	25149	45	9	31	5	30
RFA_00815	R2_retro_el links to Rfam database...	0.57	0.61	0.54	25	24485	29	4	17	8	16
RFA_00816	R2_retro_el links to Rfam database...	0.63	0.66	0.60	27	23175	24	11	7	6	14
RFA_00817	R2_retro_el links to Rfam database...	0.10	0.12	0.08	5	21883	57	17	40	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.48	0.54	0.43	22	20250	30	12	17	1	19
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	33	0	1	32	2
SRP_00016	Archaea_SRP links to Rfam database...	0.79	0.78	0.80	85	47789	22	3	18	1	24
SRP_00130	Archaea_SRP links to Rfam database...	0.48	0.48	0.48	47	49672	54	5	46	3	50
SRP_00142	Archaea_SRP links to Rfam database...	0.31	0.31	0.31	29	45962	66	7	58	1	64
SRP_00143	Archaea_SRP links to Rfam database...	0.37	0.38	0.36	38	49664	70	8	60	2	63
SRP_00144	Archaea_SRP links to Rfam database...	0.38	0.39	0.38	37	46567	65	7	54	4	57
SRP_00197	Archaea_SRP links to Rfam database...	0.21	0.20	0.24	20	49370	65	3	62	0	81
SRP_00198	Archaea_SRP links to Rfam database...	0.22	0.21	0.23	22	50943	75	7	68	0	81
SRP_00199	Archaea_SRP links to Rfam database...	0.65	0.65	0.65	68	50935	39	3	34	2	37
SRP_00201	Archaea_SRP links to Rfam database...	0.72	0.70	0.73	78	47788	31	1	28	2	33
SRP_00202	Archaea_SRP links to Rfam database...	0.87	0.86	0.87	101	54169	18	2	13	3	16
SRP_00203	Archaea_SRP links to Rfam database...	0.73	0.74	0.71	78	48718	41	1	31	9	27
SRP_00204	Archaea_SRP links to Rfam database...	0.66	0.67	0.65	68	49037	37	7	29	1	34
SRP_00206	Archaea_SRP links to Rfam database...	0.84	0.83	0.84	90	47788	18	5	12	1	18
SRP_00208	Archaea_SRP links to Rfam database...	0.64	0.62	0.66	63	46569	34	7	26	1	38
SRP_00255	Archaea_SRP links to Rfam database...	0.60	0.62	0.59	58	47487	45	2	39	4	36
SRP_00276	Archaea_SRP links to Rfam database...	0.86	0.85	0.86	94	50612	16	5	10	1	16
SRP_00278	Archaea_SRP links to Rfam database...	0.67	0.68	0.66	71	45949	39	6	30	3	34
SRP_00321	Archaea_SRP links to Rfam database...	0.56	0.56	0.55	61	47475	51	10	40	1	47
SRP_00322	Archaea_SRP links to Rfam database...	0.67	0.65	0.68	71	48412	34	1	32	1	38
SRP_00323	Archaea_SRP links to Rfam database...	0.81	0.80	0.82	86	47173	22	0	19	3	21
SRP_00330	Archaea_SRP links to Rfam database...	0.47	0.46	0.49	44	49996	47	4	42	1	51
SRP_00332	Archaea_SRP links to Rfam database...	0.70	0.71	0.69	75	50295	34	7	26	1	31
SRP_00339	Archaea_SRP links to Rfam database...	0.66	0.66	0.66	62	44457	36	2	30	4	32

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of MaxExpect - scored higher in this pairwise comparison

1. Total counts & total scores for MaxExpect

2. Individual counts for MaxExpect [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]