CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	McQFold		CMfinder(seed)
MCC	0.492	>	0.454
Average MCC ± 95% Confidence Intervals	0.484 ± 0.063	>	0.456 ± 0.042
Sensitivity	0.484	>	0.271
Positive Predictive Value	0.500	<	0.762
Total TP	2230	>	1249
Total TN	2620234	<	2623051
Total FP	2490	>	419
Total FP CONTRA	389	>	30
Total FP INCONS	1837	>	360
Total FP COMP	264	>	29
Total FN	2373	<	3354
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of McQFold and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for McQFold and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for McQFold and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for McQFold and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for McQFold and CMfinder(seed)).

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Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP	2230
Total TN	2620234
Total FP	2490
Total FP CONTRA	389
Total FP INCONS	1837
Total FP COMP	264
Total FN	2373

Total Scores
MCC	0.492
Average MCC ± 95% Confidence Intervals	0.484 ± 0.063
Sensitivity	0.484
Positive Predictive Value	0.500
Nr of predictions	51

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2. Individual counts for McQFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.10	0.10	0.11	11	103641	107	9	79	19	104
CRW_00016	Intron_gpI links to Rfam database...	0.66	0.61	0.72	73	77320	38	5	23	10	47
CRW_00610	Intron_gpI links to Rfam database...	0.50	0.48	0.51	39	36239	38	6	31	1	42
CRW_00613	Intron_gpI links to Rfam database...	0.81	0.73	0.89	57	34916	15	0	7	8	21
CRW_00614	Intron_gpI links to Rfam database...	0.07	0.09	0.06	5	121689	132	26	51	55	52
CRW_00618	Intron_gpI links to Rfam database...	0.37	0.39	0.34	24	56210	60	15	31	14	37
CRW_00633	Intron_gpI links to Rfam database...	0.74	0.72	0.77	76	63447	26	8	15	3	30
CRW_00634	Intron_gpI links to Rfam database...	0.44	0.41	0.47	39	64537	48	18	26	4	55
CRW_00670	Intron_gpI links to Rfam database...	0.54	0.53	0.55	63	70011	53	6	45	2	57
CRW_00671	Intron_gpI links to Rfam database...	0.66	0.59	0.74	69	62742	28	5	19	4	48
CRW_00672	Intron_gpI links to Rfam database...	0.52	0.50	0.56	55	72291	48	9	35	4	56
CRW_00674	Intron_gpI links to Rfam database...	0.43	0.42	0.44	52	83319	69	14	51	4	72
CRW_00676	Intron_gpI links to Rfam database...	0.30	0.30	0.31	35	93414	85	9	70	6	80
CRW_00692	Intron_gpI links to Rfam database...	0.26	0.27	0.25	24	68538	77	23	50	4	66
PDB_00827	Intron_gpI links to Rfam database...	0.68	0.59	0.79	48	26967	15	0	13	2	33
RFA_00606	Telomerase-cil links to Rfam database...	0.32	0.33	0.32	13	21280	34	12	16	6	26
RFA_00620	Telomerase-cil links to Rfam database...	0.36	0.38	0.34	15	21901	37	4	25	8	24
RFA_00626	rne5 links to Rfam database...	0.21	0.22	0.21	19	56526	76	15	56	5	68
RFA_00627	rne5 links to Rfam database...	0.42	0.40	0.44	35	56873	47	13	32	2	52
RFA_00628	rne5 links to Rfam database...	0.42	0.41	0.43	35	57209	50	7	40	3	51
RFA_00630	rne5 links to Rfam database...	0.63	0.63	0.63	55	56865	41	6	27	8	32
RFA_00639	7SK links to Rfam database...	0.37	0.39	0.36	34	54520	66	13	48	5	53
RFA_00814	R2_retro_el links to Rfam database...	0.79	0.80	0.77	33	25157	21	0	10	11	8
RFA_00815	R2_retro_el links to Rfam database...	0.56	0.59	0.53	24	24486	27	1	20	6	17
RFA_00816	R2_retro_el links to Rfam database...	0.82	0.85	0.80	35	23176	12	4	5	3	6
RFA_00817	R2_retro_el links to Rfam database...	0.35	0.39	0.31	16	21894	39	9	26	4	25
RFA_00818	R2_retro_el links to Rfam database...	0.28	0.27	0.29	11	20263	30	12	15	3	30
RFA_00819	R2_retro_el links to Rfam database...	0.30	0.29	0.31	12	27927	50	4	23	23	29
SRP_00016	Archaea_SRP links to Rfam database...	0.49	0.49	0.50	53	47789	54	4	49	1	56
SRP_00130	Archaea_SRP links to Rfam database...	0.54	0.52	0.56	50	49681	44	3	36	5	47
SRP_00142	Archaea_SRP links to Rfam database...	0.14	0.14	0.14	13	45961	82	8	74	0	80
SRP_00143	Archaea_SRP links to Rfam database...	0.54	0.53	0.56	54	49673	48	2	41	5	47
SRP_00144	Archaea_SRP links to Rfam database...	0.64	0.65	0.64	61	46569	37	4	31	2	33
SRP_00197	Archaea_SRP links to Rfam database...	0.21	0.20	0.22	20	49363	73	10	62	1	81
SRP_00198	Archaea_SRP links to Rfam database...	0.08	0.08	0.09	8	50954	78	7	71	0	95
SRP_00199	Archaea_SRP links to Rfam database...	0.13	0.11	0.14	12	50956	72	6	66	0	93
SRP_00201	Archaea_SRP links to Rfam database...	0.73	0.72	0.74	80	47787	30	2	26	2	31
SRP_00202	Archaea_SRP links to Rfam database...	0.88	0.89	0.88	104	54167	15	5	9	1	13
SRP_00203	Archaea_SRP links to Rfam database...	0.73	0.74	0.71	78	48718	39	2	30	7	27
SRP_00204	Archaea_SRP links to Rfam database...	0.80	0.77	0.83	79	49046	17	5	11	1	23
SRP_00206	Archaea_SRP links to Rfam database...	0.76	0.72	0.80	78	47797	21	7	13	1	30
SRP_00208	Archaea_SRP links to Rfam database...	0.61	0.58	0.64	59	46573	35	6	27	2	42
SRP_00255	Archaea_SRP links to Rfam database...	0.26	0.28	0.25	26	47484	76	14	62	0	68
SRP_00276	Archaea_SRP links to Rfam database...	0.54	0.54	0.55	59	50614	49	8	40	1	51
SRP_00278	Archaea_SRP links to Rfam database...	0.75	0.74	0.76	78	45953	28	5	20	3	27
SRP_00321	Archaea_SRP links to Rfam database...	0.62	0.62	0.63	67	47479	42	8	32	2	41
SRP_00322	Archaea_SRP links to Rfam database...	0.68	0.69	0.68	75	48405	36	4	32	0	34
SRP_00323	Archaea_SRP links to Rfam database...	0.60	0.61	0.60	65	47169	46	4	40	2	42
SRP_00330	Archaea_SRP links to Rfam database...	0.10	0.11	0.10	10	49988	88	11	77	0	85
SRP_00332	Archaea_SRP links to Rfam database...	0.49	0.50	0.49	53	50295	56	3	52	1	53
SRP_00339	Archaea_SRP links to Rfam database...	0.43	0.44	0.43	41	44455	55	8	47	0	53

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of McQFold - scored higher in this pairwise comparison

1. Total counts & total scores for McQFold

2. Individual counts for McQFold [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]