CompaRNA - on-line benchmarks of RNA structure prediction methods
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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Multilign(20) - scored higher in this pairwise comparison

  4. Performance of Carnac(seed) - scored lower in this pairwise comparison

  5. Compile and download dataset for Multilign(20) & Carnac(seed) [.zip] - may take several seconds...


Overview

Metric Multilign(20) Carnac(seed)
MCC 0.725 > 0.000
Average MCC ± 95% Confidence Intervals 0.729 ± 0.083 > 0.000 ± 0.000
Sensitivity 0.653 > 0.000
Positive Predictive Value 0.807 > 0.000
Total TP 472 > 0
Total TN 420058 < 420643
Total FP 151 > 0
Total FP CONTRA 24 > 0
Total FP INCONS 89 > 0
Total FP COMP 38 > 0
Total FN 251 < 723
P-value 0.0

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Performance plots


  1. Comparison of performance of Multilign(20) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and Carnac(seed)).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Multilign(20) and Carnac(seed)).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and Carnac(seed)).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP 472
Total TN 420058
Total FP 151
Total FP CONTRA 24
Total FP INCONS 89
Total FP COMP 38
Total FN 251
Total Scores
MCC 0.725
Average MCC ± 95% Confidence Intervals 0.729 ± 0.083
Sensitivity 0.653
Positive Predictive Value 0.807
Nr of predictions 7

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00599 0.71 0.71 0.71 79 101363 50 13 20 17 32
RFA_00601 0.58 0.54 0.61 62 99134 50 10 29 11 52
SRP_00152 0.81 0.74 0.89 76 45668 12 0 9 3 27
SRP_00178 0.83 0.75 0.93 76 45671 8 0 6 2 26
SRP_00179 0.76 0.66 0.88 69 45978 12 1 8 3 36
SRP_00184 0.76 0.68 0.85 68 45976 14 0 12 2 32
SRP_00308 0.65 0.48 0.89 42 36268 5 0 5 0 46

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP 0
Total TN 420643
Total FP 0
Total FP CONTRA 0
Total FP INCONS 0
Total FP COMP 0
Total FN 723
Total Scores
MCC 0.000
Average MCC ± 95% Confidence Intervals 0.000 ± 0.000
Sensitivity 0.000
Positive Predictive Value 0.000
Nr of predictions 7

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
RFA_00599 0.00 0.00 0.00 0 101475 0 0 0 0 111
RFA_00601 0.00 0.00 0.00 0 99235 0 0 0 0 114
SRP_00152 0.00 0.00 0.00 0 45753 0 0 0 0 103
SRP_00178 0.00 0.00 0.00 0 45753 0 0 0 0 102
SRP_00179 0.00 0.00 0.00 0 46056 0 0 0 0 105
SRP_00184 0.00 0.00 0.00 0 46056 0 0 0 0 100
SRP_00308 0.00 0.00 0.00 0 36315 0 0 0 0 88

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.