CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Multilign(20)		RNASampler(20)
MCC	0.619	>	0.554
Average MCC ± 95% Confidence Intervals	0.605 ± 0.045	>	0.529 ± 0.047
Sensitivity	0.560	>	0.404
Positive Predictive Value	0.685	<	0.762
Total TP	3521	>	2540
Total TN	3686992	<	3688794
Total FP	1957	>	1025
Total FP CONTRA	352	>	229
Total FP INCONS	1264	>	566
Total FP COMP	341	>	230
Total FN	2761	<	3742
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Multilign(20) and RNASampler(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Multilign(20) and RNASampler(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Multilign(20) and RNASampler(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Multilign(20) and RNASampler(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Multilign(20) and RNASampler(20)).

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Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

Total Base Pair Counts
Total TP	3521
Total TN	3686992
Total FP	1957
Total FP CONTRA	352
Total FP INCONS	1264
Total FP COMP	341
Total FN	2761

Total Scores
MCC	0.619
Average MCC ± 95% Confidence Intervals	0.605 ± 0.045
Sensitivity	0.560
Positive Predictive Value	0.685
Nr of predictions	66

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2. Individual counts for Multilign(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.76	0.67	0.86	60	45381	21	0	10	11	29
ASE_00090	RNaseP_bact_a links to Rfam database...	0.52	0.46	0.60	46	55534	36	5	26	5	55
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.49	0.60	53	63102	40	6	29	5	56
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.37	0.39	27	57560	76	9	34	33	46
ASE_00215	RNaseP_bact_a links to Rfam database...	0.18	0.15	0.23	15	48450	55	4	47	4	84
ASE_00305	RNaseP_bact_b links to Rfam database...	0.77	0.73	0.82	62	54539	23	0	14	9	23
ASE_00328	RNaseP_bact_b links to Rfam database...	0.76	0.67	0.87	75	72685	23	1	10	12	37
ASE_00361	RNaseP_bact_a links to Rfam database...	0.58	0.49	0.69	62	75376	29	3	25	1	65
ASE_00427	RNaseP_nuc links to Rfam database...	0.17	0.20	0.15	9	40695	59	19	32	8	37
ASE_00441	RNaseP_bact_a links to Rfam database...	0.66	0.57	0.77	64	64178	19	2	17	0	48
SRP_00006	Metazoa_SRP links to Rfam database...	0.86	0.85	0.88	86	45655	15	2	10	3	15
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.51	0.34	0.77	30	37636	9	0	9	0	57
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.71	0.66	0.76	58	36780	24	0	18	6	30
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.81	0.83	0.79	73	36764	19	3	16	0	15
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.81	0.78	0.84	69	36233	16	0	13	3	20
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.49	0.34	0.70	30	36542	13	0	13	0	57
SRP_00050	Metazoa_SRP links to Rfam database...	0.70	0.65	0.75	64	44765	22	1	20	1	35
SRP_00066	Metazoa_SRP links to Rfam database...	0.78	0.76	0.81	76	45357	18	1	17	0	24
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	34151	40	7	33	0	89
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35748	30	1	29	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.53	0.36	0.78	32	35470	9	0	9	0	58
SRP_00103	Metazoa_SRP links to Rfam database...	0.77	0.71	0.84	72	45365	14	1	13	0	30
SRP_00152	Plant_SRP links to Rfam database...	0.81	0.74	0.89	76	45668	12	0	9	3	27
SRP_00178	Plant_SRP links to Rfam database...	0.83	0.75	0.93	76	45671	8	0	6	2	26
SRP_00179	Plant_SRP links to Rfam database...	0.76	0.66	0.88	69	45978	12	1	8	3	36
SRP_00228	Metazoa_SRP links to Rfam database...	0.76	0.69	0.84	66	45372	19	1	12	6	29
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.80	0.78	0.83	67	36234	20	1	13	6	19
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.65	0.48	0.89	42	36268	5	0	5	0	46
SRP_00317	Metazoa_SRP links to Rfam database...	0.84	0.80	0.90	78	45063	14	1	8	5	20
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.29	0.31	0.28	12	35202	34	17	14	3	27
SRP_00347	Metazoa_SRP links to Rfam database...	0.74	0.70	0.79	67	46580	20	4	14	2	29
SRP_00368	Metazoa_SRP links to Rfam database...	0.36	0.33	0.40	32	43875	49	6	43	0	66
TMR_00017	tmRNA links to Rfam database...	0.59	0.56	0.62	57	67069	39	8	27	4	45
TMR_00018	tmRNA links to Rfam database...	0.59	0.54	0.65	50	64543	31	7	20	4	42
TMR_00042	tmRNA links to Rfam database...	0.61	0.57	0.65	56	62749	34	7	23	4	42
TMR_00046	tmRNA links to Rfam database...	0.65	0.63	0.67	60	62746	35	9	20	6	36
TMR_00048	tmRNA links to Rfam database...	0.59	0.55	0.63	52	64898	38	6	24	8	43
TMR_00080	tmRNA links to Rfam database...	0.51	0.46	0.56	44	70422	34	10	24	0	52
TMR_00082	tmRNA links to Rfam database...	0.65	0.59	0.71	57	67816	30	7	16	7	39
TMR_00123	tmRNA links to Rfam database...	0.64	0.59	0.68	60	66342	34	4	24	6	41
TMR_00137	tmRNA links to Rfam database...	0.33	0.28	0.38	25	61009	44	9	32	3	64
TMR_00142	tmRNA links to Rfam database...	0.62	0.64	0.61	65	70769	49	12	30	7	37
TMR_00207	tmRNA links to Rfam database...	0.40	0.35	0.45	36	72310	49	6	38	5	67
TMR_00257	tmRNA links to Rfam database...	0.68	0.61	0.76	60	67082	27	4	15	8	38
TMR_00271	tmRNA links to Rfam database...	0.64	0.56	0.74	51	64192	20	6	12	2	40
TMR_00366	tmRNA links to Rfam database...	0.64	0.60	0.67	60	67807	40	12	17	11	40
TMR_00378	tmRNA links to Rfam database...	0.67	0.63	0.71	61	67810	38	5	20	13	36
TMR_00404	tmRNA links to Rfam database...	0.59	0.59	0.60	54	67438	49	12	24	13	38
TMR_00427	tmRNA links to Rfam database...	0.53	0.41	0.69	40	67470	22	7	11	4	57
TMR_00443	tmRNA links to Rfam database...	0.67	0.59	0.77	61	67082	22	4	14	4	43
TMR_00451	tmRNA links to Rfam database...	0.52	0.45	0.60	40	63479	31	7	20	4	49
TMR_00458	tmRNA links to Rfam database...	0.70	0.63	0.77	59	63469	21	4	14	3	34
TMR_00469	tmRNA links to Rfam database...	0.75	0.73	0.78	73	64526	30	7	14	9	27
TMR_00472	tmRNA links to Rfam database...	0.76	0.73	0.80	71	64531	23	7	11	5	26
TMR_00519	tmRNA links to Rfam database...	0.60	0.57	0.64	54	63106	34	12	18	4	41
TMR_00520	tmRNA links to Rfam database...	0.67	0.62	0.73	61	63106	31	4	19	8	38
TMR_00522	tmRNA links to Rfam database...	0.53	0.47	0.60	46	63113	36	9	22	5	51
TMR_00528	tmRNA links to Rfam database...	0.51	0.45	0.58	44	63114	37	10	22	5	53
TMR_00568	tmRNA links to Rfam database...	0.62	0.59	0.65	58	60637	40	8	23	9	41
TMR_00571	tmRNA links to Rfam database...	0.69	0.65	0.73	64	60638	34	10	14	10	35
TMR_00580	tmRNA links to Rfam database...	0.62	0.61	0.63	61	60629	46	10	26	10	39
TMR_00584	tmRNA links to Rfam database...	0.65	0.61	0.69	59	60989	36	6	21	9	38
TMR_00586	tmRNA links to Rfam database...	0.60	0.59	0.61	57	60982	43	11	25	7	40
TMR_00616	tmRNA links to Rfam database...	0.65	0.63	0.68	62	67070	35	7	22	6	37
TMR_00699	tmRNA links to Rfam database...	0.69	0.60	0.80	61	67085	16	2	13	1	41
TMR_00702	tmRNA links to Rfam database...	0.63	0.54	0.73	54	67087	26	7	13	6	46

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Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	2540
Total TN	3688794
Total FP	1025
Total FP CONTRA	229
Total FP INCONS	566
Total FP COMP	230
Total FN	3742

Total Scores
MCC	0.554
Average MCC ± 95% Confidence Intervals	0.529 ± 0.047
Sensitivity	0.404
Positive Predictive Value	0.762
Nr of predictions	66

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Multilign(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Multilign(20)

2. Individual counts for Multilign(20) [ download as .csv ]

Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]