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Table of contents:

  1. Overview

  2. Performance Plots

  3. Performance of Murlet(20) - scored higher in this pairwise comparison

  4. Performance of Afold - scored lower in this pairwise comparison

  5. Compile and download dataset for Murlet(20) & Afold [.zip] - may take several seconds...


Overview

Metric Murlet(20) Afold
MCC 0.550 > 0.546
Average MCC ± 95% Confidence Intervals 0.551 ± 0.025 > 0.542 ± 0.030
Sensitivity 0.410 < 0.535
Positive Predictive Value 0.739 > 0.559
Total TP 5055 < 6599
Total TN 6874863 > 6869907
Total FP 1988 < 5844
Total FP CONTRA 192 < 623
Total FP INCONS 1596 < 4577
Total FP COMP 200 < 644
Total FN 7275 > 5731
P-value 0.0106540216989

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Performance plots


  1. Comparison of performance of Murlet(20) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and Afold).

  2. Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and Afold).

  3. Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and Afold).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP 5055
Total TN 6874863
Total FP 1988
Total FP CONTRA 192
Total FP INCONS 1596
Total FP COMP 200
Total FN 7275
Total Scores
MCC 0.550
Average MCC ± 95% Confidence Intervals 0.551 ± 0.025
Sensitivity 0.410
Positive Predictive Value 0.739
Nr of predictions 120

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00004 0.46 0.34 0.61 33 47841 21 1 20 0 64
ASE_00007 0.71 0.57 0.89 63 59614 8 2 6 0 47
ASE_00028 0.56 0.40 0.77 51 84600 15 5 10 0 75
ASE_00040 0.62 0.43 0.90 57 78940 6 0 6 0 76
ASE_00045 0.73 0.56 0.94 45 47230 4 0 3 1 35
ASE_00064 0.55 0.39 0.76 35 45405 14 3 8 3 54
ASE_00068 0.62 0.42 0.90 36 37635 4 3 1 0 49
ASE_00075 0.51 0.34 0.76 55 108739 19 1 16 2 107
ASE_00077 0.48 0.35 0.67 30 45105 18 0 15 3 56
ASE_00078 0.64 0.53 0.79 44 43015 12 3 9 0 39
ASE_00080 0.31 0.21 0.46 26 71574 31 3 28 0 97
ASE_00081 0.73 0.58 0.93 56 49710 5 0 4 1 41
ASE_00082 0.27 0.20 0.37 23 70438 42 2 37 3 93
ASE_00083 0.54 0.39 0.75 43 62424 14 2 12 0 67
ASE_00084 0.53 0.36 0.77 36 53581 12 0 11 1 63
ASE_00087 0.35 0.21 0.58 30 88358 22 0 22 0 114
ASE_00092 0.58 0.40 0.85 45 63493 10 0 8 2 68
ASE_00104 0.51 0.38 0.69 45 64196 20 1 19 0 74
ASE_00114 0.46 0.39 0.56 30 45397 28 2 22 4 47
ASE_00115 0.46 0.30 0.71 30 54573 12 1 11 0 71
ASE_00119 0.11 0.08 0.16 9 62779 48 2 45 1 99
ASE_00123 0.55 0.40 0.76 34 38458 11 0 11 0 51
ASE_00135 0.34 0.24 0.49 26 63137 29 3 24 2 83
ASE_00138 0.60 0.47 0.76 38 40420 13 0 12 1 43
ASE_00146 0.70 0.56 0.87 69 70797 13 0 10 3 55
ASE_00153 0.34 0.23 0.50 17 57596 26 3 14 9 56
ASE_00161 0.68 0.56 0.83 49 53569 16 0 10 6 38
ASE_00163 0.47 0.32 0.70 30 53258 13 0 13 0 63
ASE_00170 0.52 0.37 0.74 34 48782 12 0 12 0 59
ASE_00174 0.30 0.23 0.39 25 61011 43 2 37 4 84
ASE_00179 0.49 0.40 0.61 34 44197 22 0 22 0 50
ASE_00180 0.70 0.55 0.90 55 51299 6 2 4 0 45
ASE_00182 0.24 0.15 0.41 20 84206 31 1 28 2 116
ASE_00185 0.28 0.16 0.48 21 73492 23 0 23 0 107
ASE_00186 0.61 0.45 0.84 59 78933 11 1 10 0 73
ASE_00190 0.38 0.22 0.67 20 45421 12 0 10 2 70
ASE_00212 0.55 0.39 0.78 58 93887 16 1 15 0 90
ASE_00214 0.40 0.27 0.58 28 56232 21 1 19 1 75
ASE_00215 0.46 0.31 0.69 31 48471 14 4 10 0 68
ASE_00217 0.66 0.50 0.87 45 40418 7 1 6 0 45
ASE_00221 0.58 0.44 0.78 51 64555 14 0 14 0 66
ASE_00228 0.53 0.44 0.63 38 46911 23 1 21 1 48
ASE_00229 0.61 0.48 0.76 42 42431 13 3 10 0 45
ASE_00238 0.45 0.30 0.68 34 64211 16 2 14 0 80
ASE_00241 0.66 0.55 0.79 48 43895 16 2 11 3 39
ASE_00255 0.53 0.39 0.72 51 74620 21 1 19 1 79
ASE_00257 0.55 0.43 0.69 42 50979 19 0 19 0 55
ASE_00267 0.76 0.61 0.95 54 45093 4 2 1 1 34
ASE_00270 0.21 0.14 0.32 18 72333 41 0 39 2 110
ASE_00279 0.63 0.48 0.84 48 53244 9 1 8 0 53
ASE_00280 0.67 0.54 0.84 53 51940 10 3 7 0 45
ASE_00283 0.55 0.41 0.73 44 61716 16 0 16 0 63
ASE_00285 0.45 0.33 0.62 40 68941 25 1 24 0 82
ASE_00292 0.52 0.36 0.74 50 81742 18 1 17 0 88
ASE_00294 0.55 0.37 0.83 63 114405 14 4 9 1 108
ASE_00297 0.59 0.41 0.85 40 52928 10 0 7 3 58
ASE_00298 0.22 0.15 0.32 17 67475 36 4 32 0 96
ASE_00305 0.62 0.51 0.75 43 54558 21 1 13 7 42
ASE_00321 0.66 0.52 0.84 46 54560 18 1 8 9 42
ASE_00328 0.59 0.48 0.72 54 72696 27 5 16 6 58
ASE_00332 0.63 0.47 0.83 65 81732 13 2 11 0 73
ASE_00340 0.45 0.34 0.60 29 46008 22 3 16 3 56
ASE_00361 0.57 0.39 0.82 50 75405 11 1 10 0 77
ASE_00362 0.56 0.38 0.81 35 48162 12 0 8 4 56
ASE_00363 0.61 0.44 0.85 41 51312 7 0 7 0 53
ASE_00364 0.58 0.38 0.89 40 54240 5 0 5 0 65
ASE_00366 0.49 0.36 0.67 35 58601 19 0 17 2 63
ASE_00367 0.71 0.57 0.89 49 43016 6 2 4 0 37
ASE_00372 0.40 0.31 0.53 31 51944 28 3 25 0 69
ASE_00376 0.57 0.40 0.82 42 56902 9 2 7 0 63
ASE_00382 0.65 0.51 0.83 43 41853 9 2 7 0 41
ASE_00384 0.59 0.43 0.80 40 48466 10 2 8 0 52
ASE_00386 0.54 0.36 0.80 35 50359 9 1 8 0 61
ASE_00387 0.64 0.45 0.90 47 55893 5 0 5 0 57
ASE_00388 0.53 0.38 0.72 34 45706 16 1 12 3 55
ASE_00390 0.77 0.64 0.93 54 42137 6 1 3 2 31
ASE_00393 0.55 0.41 0.73 38 47843 15 3 11 1 55
ASE_00394 0.56 0.41 0.78 38 46922 11 1 10 0 55
ASE_00395 0.68 0.51 0.90 43 41568 5 0 5 0 41
ASE_00396 0.62 0.47 0.81 39 41568 9 0 9 0 44
ASE_00397 0.63 0.45 0.89 47 54562 9 1 5 3 58
ASE_00398 0.49 0.32 0.75 33 55901 12 0 11 1 71
ASE_00400 0.47 0.36 0.61 38 57908 25 3 21 1 68
ASE_00402 0.55 0.35 0.86 30 42451 5 2 3 0 55
ASE_00404 0.72 0.55 0.94 47 43021 4 0 3 1 38
ASE_00411 0.59 0.39 0.88 35 49415 5 0 5 0 54
ASE_00416 0.45 0.33 0.62 42 77353 26 1 25 0 85
ASE_00419 0.49 0.33 0.74 34 54900 12 2 10 0 69
ASE_00422 0.50 0.35 0.70 33 46924 14 0 14 0 61
ASE_00427 0.42 0.43 0.41 20 40706 41 10 19 12 26
ASE_00428 0.47 0.34 0.67 42 76573 21 4 17 0 83
ASE_00430 0.50 0.37 0.68 36 46918 17 0 17 0 61
ASE_00437 0.42 0.32 0.56 43 79324 34 3 31 0 92
ASE_00448 0.63 0.49 0.82 55 64194 12 3 9 0 57
ASE_00451 0.56 0.41 0.76 51 70809 16 1 15 0 74
RFA_00599 0.44 0.34 0.58 38 101409 33 1 27 5 73
RFA_00601 0.31 0.23 0.42 26 99173 43 3 33 7 88
RFA_00602 0.24 0.16 0.35 19 101421 41 2 33 6 97
SRP_00006 0.95 0.90 1.00 91 45662 4 0 0 4 10
SRP_00011 0.63 0.52 0.77 54 46290 18 0 16 2 50
SRP_00015 0.73 0.63 0.86 62 46288 17 0 10 7 37
SRP_00024 0.53 0.31 0.90 27 37645 3 0 3 0 60
SRP_00026 0.52 0.31 0.90 27 36826 4 0 3 1 61
SRP_00030 0.51 0.33 0.78 29 36819 8 4 4 0 59
SRP_00031 0.53 0.31 0.90 28 36284 4 0 3 1 61
SRP_00086 0.74 0.66 0.84 66 44174 13 7 6 0 34
SRP_00152 0.75 0.64 0.87 66 45677 14 5 5 4 37
SRP_00171 0.66 0.65 0.68 57 45367 35 6 21 8 31
SRP_00178 0.74 0.57 0.97 58 45693 3 0 2 1 44
SRP_00181 0.71 0.57 0.89 58 45991 9 0 7 2 44
SRP_00182 0.78 0.68 0.90 69 45979 9 0 8 1 32
SRP_00184 0.65 0.53 0.79 53 45989 17 0 14 3 47
SRP_00317 0.78 0.68 0.88 67 45074 14 0 9 5 31
SRP_00337 0.59 0.42 0.83 38 35465 9 0 8 1 53
SRP_00347 0.72 0.65 0.79 62 46587 23 1 15 7 34
TMR_00038 0.67 0.53 0.84 58 71184 13 5 6 2 52
TMR_00046 0.60 0.52 0.69 50 62763 23 6 16 1 46
TMR_00048 0.56 0.48 0.66 46 64910 29 9 15 5 49
TMR_00458 0.50 0.41 0.61 38 63484 29 4 20 5 55
TMR_00568 0.72 0.64 0.82 63 60649 18 3 11 4 36

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Performance of Afold - scored lower in this pairwise comparison

1. Total counts & total scores for Afold

Total Base Pair Counts
Total TP 6599
Total TN 6869907
Total FP 5844
Total FP CONTRA 623
Total FP INCONS 4577
Total FP COMP 644
Total FN 5731
Total Scores
MCC 0.546
Average MCC ± 95% Confidence Intervals 0.542 ± 0.030
Sensitivity 0.535
Positive Predictive Value 0.559
Nr of predictions 120

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2. Individual counts for Afold [ download as .csv ]

RNA Chain Rfam family MCC SENS PPV TP TN FP FP CONTRA FP INCONS FP COMP FN
ASE_00004 0.51 0.52 0.51 50 47797 49 10 38 1 47
ASE_00007 0.56 0.53 0.59 58 59586 45 1 40 4 52
ASE_00028 0.58 0.56 0.61 70 84551 54 4 41 9 56
ASE_00040 0.50 0.47 0.53 63 78883 63 5 52 6 70
ASE_00045 0.65 0.65 0.65 52 47198 37 7 21 9 28
ASE_00064 0.43 0.43 0.44 38 45364 54 5 44 5 51
ASE_00068 0.33 0.32 0.36 27 37599 50 2 47 1 58
ASE_00075 0.65 0.59 0.72 95 108679 46 3 34 9 67
ASE_00077 0.52 0.51 0.54 44 45068 39 6 32 1 42
ASE_00078 0.67 0.67 0.67 56 42988 32 5 22 5 27
ASE_00080 0.50 0.48 0.52 59 71518 59 3 51 5 64
ASE_00081 0.46 0.45 0.46 44 49675 53 5 46 2 53
ASE_00082 0.57 0.54 0.61 63 70396 51 1 40 10 53
ASE_00083 0.71 0.67 0.76 74 62383 32 1 23 8 36
ASE_00084 0.72 0.71 0.73 70 53532 30 6 20 4 29
ASE_00087 0.56 0.51 0.61 74 88288 54 5 43 6 70
ASE_00092 0.68 0.65 0.72 73 63444 35 3 26 6 40
ASE_00104 0.53 0.50 0.56 60 64153 49 8 40 1 59
ASE_00114 0.40 0.40 0.39 31 45372 58 6 42 10 46
ASE_00115 0.55 0.54 0.56 55 54517 51 1 42 8 46
ASE_00119 0.63 0.60 0.67 65 62738 35 1 31 3 43
ASE_00123 0.44 0.42 0.46 36 38425 48 3 39 6 49
ASE_00135 0.45 0.44 0.45 48 63084 63 8 50 5 61
ASE_00138 0.51 0.49 0.53 40 40395 36 4 31 1 41
ASE_00146 0.55 0.52 0.59 64 70768 50 2 42 6 60
ASE_00153 0.66 0.67 0.65 49 57555 68 2 24 42 24
ASE_00161 0.27 0.29 0.26 25 53531 73 15 57 1 62
ASE_00163 0.64 0.63 0.66 59 53211 43 4 27 12 34
ASE_00170 0.70 0.68 0.72 63 48740 27 2 23 2 30
ASE_00174 0.59 0.57 0.62 62 60975 42 6 32 4 47
ASE_00179 0.64 0.65 0.62 55 44164 35 7 27 1 29
ASE_00180 0.71 0.69 0.74 69 51267 31 2 22 7 31
ASE_00182 0.60 0.58 0.62 79 84128 49 6 42 1 57
ASE_00185 0.72 0.70 0.74 89 73416 38 6 25 7 39
ASE_00186 0.73 0.69 0.78 91 78887 30 3 22 5 41
ASE_00190 0.49 0.46 0.52 41 45372 44 7 31 6 49
ASE_00212 0.70 0.67 0.74 99 93827 39 3 32 4 49
ASE_00214 0.72 0.72 0.73 74 56178 36 4 24 8 29
ASE_00215 0.54 0.51 0.57 50 48429 39 4 33 2 49
ASE_00217 0.40 0.37 0.45 33 40396 48 3 38 7 57
ASE_00221 0.49 0.45 0.54 53 64522 48 3 42 3 64
ASE_00228 0.52 0.53 0.50 46 46879 46 14 32 0 40
ASE_00229 0.61 0.61 0.62 53 42400 33 8 25 0 34
ASE_00238 0.59 0.59 0.60 67 64150 50 2 42 6 47
ASE_00241 0.49 0.49 0.49 43 43868 47 7 38 2 44
ASE_00255 0.64 0.62 0.66 80 74570 45 7 34 4 50
ASE_00257 0.55 0.55 0.55 53 50944 47 4 39 4 44
ASE_00267 0.32 0.31 0.34 27 45070 62 5 48 9 61
ASE_00270 0.76 0.73 0.80 94 72272 29 4 20 5 34
ASE_00279 0.68 0.66 0.71 67 53206 35 3 25 7 34
ASE_00280 0.36 0.36 0.37 35 51909 65 4 55 6 63
ASE_00283 0.75 0.73 0.77 78 61675 30 3 20 7 29
ASE_00285 0.75 0.70 0.80 86 68899 28 3 18 7 36
ASE_00292 0.62 0.58 0.66 80 81689 43 2 39 2 58
ASE_00294 0.74 0.68 0.80 117 114335 32 2 27 3 54
ASE_00297 0.50 0.50 0.51 49 52878 53 4 44 5 49
ASE_00298 0.28 0.27 0.29 31 67420 79 9 68 2 82
ASE_00305 0.47 0.47 0.47 40 54529 56 10 36 10 45
ASE_00321 0.40 0.40 0.41 35 54530 57 7 43 7 53
ASE_00328 0.40 0.41 0.40 46 72656 75 3 66 6 66
ASE_00332 0.56 0.54 0.59 75 81682 55 2 51 2 63
ASE_00340 0.76 0.73 0.78 62 45977 26 6 11 9 23
ASE_00361 0.51 0.49 0.53 62 75349 59 7 48 4 65
ASE_00362 0.61 0.60 0.61 55 48115 39 6 29 4 36
ASE_00363 0.53 0.54 0.53 51 51263 47 5 41 1 43
ASE_00364 0.42 0.42 0.43 44 54182 63 4 55 4 61
ASE_00366 0.54 0.56 0.53 55 58549 52 10 39 3 43
ASE_00367 0.28 0.29 0.27 25 42979 68 8 59 1 61
ASE_00372 0.63 0.62 0.65 62 51907 39 6 28 5 38
ASE_00376 0.48 0.46 0.50 48 56857 52 4 44 4 57
ASE_00382 0.49 0.49 0.50 41 41823 45 6 35 4 43
ASE_00384 0.41 0.39 0.43 36 48432 58 2 46 10 56
ASE_00386 0.65 0.65 0.65 62 50307 41 3 31 7 34
ASE_00387 0.43 0.43 0.43 45 55841 59 6 53 0 59
ASE_00388 0.43 0.42 0.44 37 45669 53 3 44 6 52
ASE_00390 0.44 0.42 0.47 36 42118 52 6 35 11 49
ASE_00393 0.37 0.35 0.39 33 47811 58 2 49 7 60
ASE_00394 0.69 0.68 0.70 63 46881 29 5 22 2 30
ASE_00395 0.65 0.63 0.68 53 41538 35 1 24 10 31
ASE_00396 0.16 0.16 0.16 13 41535 71 2 66 3 70
ASE_00397 0.54 0.54 0.54 57 54510 51 4 44 3 48
ASE_00398 0.61 0.58 0.65 60 55852 37 1 32 4 44
ASE_00400 0.53 0.53 0.54 56 57866 51 7 41 3 50
ASE_00402 0.41 0.40 0.43 34 42406 52 7 39 6 51
ASE_00404 0.55 0.54 0.57 46 42990 43 0 35 8 39
ASE_00411 0.35 0.35 0.35 31 49366 63 7 51 5 58
ASE_00416 0.65 0.61 0.68 78 77307 43 0 36 7 49
ASE_00419 0.75 0.73 0.78 75 54850 26 5 16 5 28
ASE_00422 0.44 0.44 0.45 41 46880 56 5 45 6 53
ASE_00427 0.15 0.20 0.12 9 40678 81 17 51 13 37
ASE_00428 0.51 0.50 0.53 62 76520 58 5 49 4 63
ASE_00430 0.64 0.63 0.66 61 46878 39 5 27 7 36
ASE_00437 0.42 0.39 0.46 53 79285 64 4 59 1 82
ASE_00448 0.22 0.22 0.23 25 64150 91 6 80 5 87
ASE_00451 0.61 0.57 0.66 71 70768 40 2 35 3 54
RFA_00599 0.67 0.70 0.64 78 101353 66 16 28 22 33
RFA_00601 0.09 0.11 0.08 12 99092 139 35 96 8 102
RFA_00602 0.50 0.53 0.47 62 101344 91 18 51 22 54
SRP_00006 0.82 0.81 0.84 82 45655 19 3 13 3 19
SRP_00011 0.43 0.42 0.45 44 46262 54 4 50 0 60
SRP_00015 0.54 0.53 0.55 52 46265 48 8 35 5 47
SRP_00024 0.68 0.70 0.67 61 37584 31 4 26 1 26
SRP_00026 0.58 0.59 0.58 52 36766 46 4 34 8 36
SRP_00030 0.74 0.75 0.73 66 36766 26 4 20 2 22
SRP_00031 0.64 0.64 0.63 57 36225 37 4 29 4 32
SRP_00086 0.71 0.71 0.70 71 44152 31 3 27 1 29
SRP_00152 0.56 0.56 0.57 58 45651 45 1 43 1 45
SRP_00171 0.00 0.00 0.00 0 45348 103 15 88 0 88
SRP_00178 0.83 0.78 0.87 80 45661 14 1 11 2 22
SRP_00181 0.33 0.31 0.35 32 45964 60 1 59 0 70
SRP_00182 0.76 0.73 0.79 74 45962 21 3 17 1 27
SRP_00184 0.62 0.60 0.64 60 45962 39 2 32 5 40
SRP_00317 0.93 0.89 0.98 87 45061 10 0 2 8 11
SRP_00337 0.73 0.71 0.76 65 35425 23 1 20 2 26
SRP_00347 0.82 0.80 0.84 77 46573 21 3 12 6 19
TMR_00038 0.25 0.25 0.25 28 71140 89 12 73 4 82
TMR_00046 0.47 0.48 0.46 46 62734 61 10 45 6 50
TMR_00048 0.35 0.37 0.34 35 64876 73 9 60 4 60
TMR_00458 0.22 0.22 0.23 20 63458 76 7 61 8 73
TMR_00568 0.57 0.57 0.58 56 60629 50 3 38 9 43

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.