CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Murlet(20)		RNASampler(20)
MCC	0.623	>	0.584
Average MCC ± 95% Confidence Intervals	0.615 ± 0.031	>	0.572 ± 0.039
Sensitivity	0.515	>	0.443
Positive Predictive Value	0.755	<	0.771
Total TP	3432	>	2956
Total TN	3911721	<	3912433
Total FP	1369	>	1115
Total FP CONTRA	244	<	258
Total FP INCONS	868	>	618
Total FP COMP	257	>	239
Total FN	3235	<	3711
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Murlet(20) and RNASampler(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(20) and RNASampler(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(20) and RNASampler(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(20) and RNASampler(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(20) and RNASampler(20)).

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Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

Total Base Pair Counts
Total TP	3432
Total TN	3911721
Total FP	1369
Total FP CONTRA	244
Total FP INCONS	868
Total FP COMP	257
Total FN	3235

Total Scores
MCC	0.623
Average MCC ± 95% Confidence Intervals	0.615 ± 0.031
Sensitivity	0.515
Positive Predictive Value	0.755
Nr of predictions	69

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2. Individual counts for Murlet(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.55	0.39	0.76	35	45405	14	3	8	3	54
ASE_00135	RNaseP_bact_a links to Rfam database...	0.34	0.24	0.49	26	63137	29	3	24	2	83
ASE_00153	RNaseP_nuc links to Rfam database...	0.34	0.23	0.50	17	57596	26	3	14	9	56
ASE_00215	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	31	48471	14	4	10	0	68
ASE_00305	RNaseP_bact_b links to Rfam database...	0.62	0.51	0.75	43	54558	21	1	13	7	42
ASE_00328	RNaseP_bact_b links to Rfam database...	0.59	0.48	0.72	54	72696	27	5	16	6	58
ASE_00361	RNaseP_bact_a links to Rfam database...	0.57	0.39	0.82	50	75405	11	1	10	0	77
ASE_00427	RNaseP_nuc links to Rfam database...	0.42	0.43	0.41	20	40706	41	10	19	12	26
SRP_00006	Metazoa_SRP links to Rfam database...	0.95	0.90	1.00	91	45662	4	0	0	4	10
SRP_00011	Plant_SRP links to Rfam database...	0.63	0.52	0.77	54	46290	18	0	16	2	50
SRP_00015	Plant_SRP links to Rfam database...	0.73	0.63	0.86	62	46288	17	0	10	7	37
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.53	0.31	0.90	27	37645	3	0	3	0	60
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.52	0.31	0.90	27	36826	4	0	3	1	61
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.51	0.33	0.78	29	36819	8	4	4	0	59
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.53	0.31	0.90	28	36284	4	0	3	1	61
SRP_00050	Metazoa_SRP links to Rfam database...	0.85	0.76	0.95	75	44771	7	0	4	3	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.74	0.67	0.83	67	45370	17	5	9	3	33
SRP_00086	Metazoa_SRP links to Rfam database...	0.74	0.66	0.84	66	44174	13	7	6	0	34
SRP_00102	Metazoa_SRP links to Rfam database...	0.76	0.68	0.84	69	44469	16	1	12	3	32
SRP_00103	Metazoa_SRP links to Rfam database...	0.75	0.65	0.87	66	45375	12	1	9	2	36
SRP_00152	Plant_SRP links to Rfam database...	0.75	0.64	0.87	66	45677	14	5	5	4	37
SRP_00171	Metazoa_SRP links to Rfam database...	0.66	0.65	0.68	57	45367	35	6	21	8	31
SRP_00178	Plant_SRP links to Rfam database...	0.74	0.57	0.97	58	45693	3	0	2	1	44
SRP_00179	Plant_SRP links to Rfam database...	0.75	0.60	0.93	63	45988	9	0	5	4	42
SRP_00181	Plant_SRP links to Rfam database...	0.71	0.57	0.89	58	45991	9	0	7	2	44
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.68	0.90	69	45979	9	0	8	1	32
SRP_00188	Plant_SRP links to Rfam database...	0.69	0.59	0.81	47	31067	12	1	10	1	32
SRP_00228	Metazoa_SRP links to Rfam database...	0.75	0.68	0.81	65	45371	19	1	14	4	30
SRP_00317	Metazoa_SRP links to Rfam database...	0.78	0.68	0.88	67	45074	14	0	9	5	31
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.59	0.42	0.83	38	35465	9	0	8	1	53
SRP_00347	Metazoa_SRP links to Rfam database...	0.72	0.65	0.79	62	46587	23	1	15	7	34
SRP_00368	Metazoa_SRP links to Rfam database...	0.78	0.70	0.87	69	43877	14	1	9	4	29
TMR_00017	tmRNA links to Rfam database...	0.72	0.60	0.87	61	67091	13	0	9	4	41
TMR_00018	tmRNA links to Rfam database...	0.56	0.49	0.65	45	64551	29	6	18	5	47
TMR_00042	tmRNA links to Rfam database...	0.56	0.44	0.70	43	62774	19	1	17	1	55
TMR_00046	tmRNA links to Rfam database...	0.60	0.52	0.69	50	62763	23	6	16	1	46
TMR_00048	tmRNA links to Rfam database...	0.56	0.48	0.66	46	64910	29	9	15	5	49
TMR_00080	tmRNA links to Rfam database...	0.54	0.49	0.60	47	70422	35	12	19	4	49
TMR_00082	tmRNA links to Rfam database...	0.59	0.50	0.71	48	67828	25	7	13	5	48
TMR_00123	tmRNA links to Rfam database...	0.64	0.50	0.81	51	66367	17	3	9	5	50
TMR_00137	tmRNA links to Rfam database...	0.54	0.46	0.64	41	61011	28	5	18	5	48
TMR_00142	tmRNA links to Rfam database...	0.64	0.60	0.69	61	70788	34	12	15	7	41
TMR_00207	tmRNA links to Rfam database...	0.53	0.42	0.66	43	72325	26	4	18	4	60
TMR_00257	tmRNA links to Rfam database...	0.56	0.48	0.64	47	67088	29	4	22	3	51
TMR_00271	tmRNA links to Rfam database...	0.55	0.42	0.72	38	64208	20	1	14	5	53
TMR_00332	tmRNA links to Rfam database...	0.70	0.58	0.85	57	67094	16	0	10	6	42
TMR_00366	tmRNA links to Rfam database...	0.53	0.49	0.58	49	67811	43	8	28	7	51
TMR_00378	tmRNA links to Rfam database...	0.57	0.51	0.64	49	67820	37	9	18	10	48
TMR_00404	tmRNA links to Rfam database...	0.53	0.41	0.68	38	67472	21	8	10	3	54
TMR_00427	tmRNA links to Rfam database...	0.20	0.13	0.30	13	67485	30	4	26	0	84
TMR_00443	tmRNA links to Rfam database...	0.73	0.61	0.88	63	67089	13	0	9	4	41
TMR_00451	tmRNA links to Rfam database...	0.52	0.46	0.58	41	63475	36	8	22	6	48
TMR_00458	tmRNA links to Rfam database...	0.50	0.41	0.61	38	63484	29	4	20	5	55
TMR_00469	tmRNA links to Rfam database...	0.64	0.48	0.84	48	64563	10	3	6	1	52
TMR_00472	tmRNA links to Rfam database...	0.70	0.61	0.81	59	64547	15	8	6	1	38
TMR_00519	tmRNA links to Rfam database...	0.49	0.37	0.65	35	63136	23	2	17	4	60
TMR_00520	tmRNA links to Rfam database...	0.44	0.35	0.54	35	63125	36	5	25	6	64
TMR_00522	tmRNA links to Rfam database...	0.49	0.39	0.60	38	63127	29	8	17	4	59
TMR_00528	tmRNA links to Rfam database...	0.48	0.41	0.57	40	63120	36	7	23	6	57
TMR_00540	tmRNA links to Rfam database...	0.53	0.45	0.63	47	73461	28	8	20	0	57
TMR_00568	tmRNA links to Rfam database...	0.72	0.64	0.82	63	60649	18	3	11	4	36
TMR_00571	tmRNA links to Rfam database...	0.76	0.67	0.86	66	60649	15	2	9	4	33
TMR_00580	tmRNA links to Rfam database...	0.75	0.66	0.86	66	60649	15	2	9	4	34
TMR_00584	tmRNA links to Rfam database...	0.71	0.62	0.81	60	61001	17	4	10	3	37
TMR_00586	tmRNA links to Rfam database...	0.71	0.63	0.79	61	60998	20	5	11	4	36
TMR_00616	tmRNA links to Rfam database...	0.67	0.58	0.79	57	67089	16	6	9	1	42
TMR_00699	tmRNA links to Rfam database...	0.57	0.43	0.75	44	67102	19	1	14	4	58
TMR_00702	tmRNA links to Rfam database...	0.54	0.43	0.68	43	67098	25	3	17	5	57
TMR_00703	tmRNA links to Rfam database...	0.58	0.45	0.75	45	67468	19	3	12	4	54

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Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	2956
Total TN	3912433
Total FP	1115
Total FP CONTRA	258
Total FP INCONS	618
Total FP COMP	239
Total FN	3711

Total Scores
MCC	0.584
Average MCC ± 95% Confidence Intervals	0.572 ± 0.039
Sensitivity	0.443
Positive Predictive Value	0.771
Nr of predictions	69

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Murlet(20) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(20)

2. Individual counts for Murlet(20) [ download as .csv ]

Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]