CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Murlet(seed)		Carnac(seed)
MCC	0.569	>	0.351
Average MCC ± 95% Confidence Intervals	0.550 ± 0.089	>	0.262 ± 0.121
Sensitivity	0.383	>	0.145
Positive Predictive Value	0.845	<	0.848
Total TP	1000	>	379
Total TN	1504247	<	1504984
Total FP	241	>	111
Total FP CONTRA	15	>	4
Total FP INCONS	169	>	64
Total FP COMP	57	>	43
Total FN	1608	<	2229
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Murlet(seed) and Carnac(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(seed) and Carnac(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(seed) and Carnac(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(seed) and Carnac(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(seed) and Carnac(seed)).

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Performance of Murlet(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP	1000
Total TN	1504247
Total FP	241
Total FP CONTRA	15
Total FP INCONS	169
Total FP COMP	57
Total FN	1608

Total Scores
MCC	0.569
Average MCC ± 95% Confidence Intervals	0.550 ± 0.089
Sensitivity	0.383
Positive Predictive Value	0.845
Nr of predictions	31

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21321	0	0	0	0	39
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21945	0	0	0	0	39
RFA_00626	rne5 links to Rfam database...	0.81	0.66	1.00	57	56559	4	0	0	4	30
RFA_00627	rne5 links to Rfam database...	0.84	0.70	1.00	61	56892	5	0	0	5	26
RFA_00628	rne5 links to Rfam database...	0.83	0.69	1.00	59	57232	8	0	0	8	27
RFA_00630	rne5 links to Rfam database...	0.82	0.67	1.00	58	56895	4	0	0	4	29
RFA_00639	7SK links to Rfam database...	0.21	0.11	0.40	10	54590	15	4	11	0	77
RFA_00814	R2_retro_el links to Rfam database...	0.75	0.63	0.90	26	25171	4	0	3	1	15
RFA_00815	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	24503	1	0	0	1	13
RFA_00816	R2_retro_el links to Rfam database...	0.75	0.63	0.90	26	23191	4	0	3	1	15
RFA_00817	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	21917	1	0	0	1	13
RFA_00818	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	20273	1	0	0	1	13
RFA_00819	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	27938	0	0	0	0	13
RFA_00820	bicoid_3 links to Rfam database...	0.71	0.56	0.89	90	151424	13	3	8	2	70
RFA_00830	bicoid_3 links to Rfam database...	0.59	0.45	0.78	70	152538	23	3	17	3	84
SRP_00079	Plant_SRP links to Rfam database...	0.54	0.33	0.88	29	41872	6	0	4	2	59
SRP_00124	Metazoa_SRP links to Rfam database...	0.15	0.09	0.24	8	37094	27	3	23	1	77
SRP_00182	Plant_SRP links to Rfam database...	0.59	0.35	1.00	35	46021	1	0	0	1	66
SRP_00197	Archaea_SRP links to Rfam database...	0.47	0.28	0.80	28	49420	8	0	7	1	73
SRP_00198	Archaea_SRP links to Rfam database...	0.47	0.27	0.82	28	51006	7	0	6	1	75
SRP_00199	Archaea_SRP links to Rfam database...	0.47	0.24	0.93	25	51013	3	0	2	1	80
SRP_00202	Archaea_SRP links to Rfam database...	0.48	0.25	0.94	29	54254	2	0	2	0	88
SRP_00241	Plant_SRP links to Rfam database...	0.51	0.33	0.79	27	46022	9	0	7	2	55
SRP_00255	Archaea_SRP links to Rfam database...	0.65	0.43	1.00	40	47546	2	0	0	2	54
SRP_00260	Metazoa_SRP links to Rfam database...	0.21	0.14	0.33	14	47852	29	1	28	0	86
SRP_00278	Archaea_SRP links to Rfam database...	0.53	0.30	0.94	31	46023	3	0	2	1	74
SRP_00322	Archaea_SRP links to Rfam database...	0.44	0.25	0.79	27	48482	8	0	7	1	82
SRP_00328	Metazoa_SRP links to Rfam database...	0.49	0.34	0.71	29	39580	16	1	11	4	56
SRP_00329	Metazoa_SRP links to Rfam database...	0.50	0.34	0.73	29	39863	16	0	11	5	56
SRP_00339	Archaea_SRP links to Rfam database...	0.49	0.32	0.77	30	44512	9	0	9	0	64
SRP_00340	Metazoa_SRP links to Rfam database...	0.44	0.27	0.73	22	41298	12	0	8	4	60

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Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

Total Base Pair Counts
Total TP	379
Total TN	1504984
Total FP	111
Total FP CONTRA	4
Total FP INCONS	64
Total FP COMP	43
Total FN	2229

Total Scores
MCC	0.351
Average MCC ± 95% Confidence Intervals	0.262 ± 0.121
Sensitivity	0.145
Positive Predictive Value	0.848
Nr of predictions	31

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2. Individual counts for Carnac(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.17	0.08	0.38	3	21313	6	1	4	1	36
RFA_00620	Telomerase-cil links to Rfam database...	0.13	0.08	0.23	3	21932	11	2	8	1	36
RFA_00626	rne5 links to Rfam database...	0.67	0.52	0.87	45	56564	11	0	7	4	42
RFA_00627	rne5 links to Rfam database...	0.69	0.55	0.86	48	56897	10	0	8	2	39
RFA_00628	rne5 links to Rfam database...	0.66	0.43	1.00	37	57254	6	0	0	6	49
RFA_00630	rne5 links to Rfam database...	0.79	0.67	0.94	58	56891	12	0	4	8	29
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54608	7	0	7	0	87
RFA_00814	R2_retro_el links to Rfam database...	0.66	0.44	1.00	18	25182	2	0	0	2	23
RFA_00815	R2_retro_el links to Rfam database...	0.75	0.56	1.00	23	24508	1	0	0	1	18
RFA_00816	R2_retro_el links to Rfam database...	0.66	0.44	1.00	18	23202	2	0	0	2	23
RFA_00817	R2_retro_el links to Rfam database...	0.80	0.66	0.96	27	21917	1	0	1	0	14
RFA_00818	R2_retro_el links to Rfam database...	0.70	0.49	1.00	20	20281	3	0	0	3	21
RFA_00819	R2_retro_el links to Rfam database...	0.75	0.56	1.00	23	27943	2	0	0	2	18
RFA_00820	bicoid_3 links to Rfam database...	0.39	0.19	0.78	31	151485	12	0	9	3	129
RFA_00830	bicoid_3 links to Rfam database...	0.31	0.16	0.60	25	152586	25	1	16	8	129
SRP_00079	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	41905	0	0	0	0	88
SRP_00124	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	37128	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	101
SRP_00197	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	49455	0	0	0	0	101
SRP_00198	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	51040	0	0	0	0	103
SRP_00199	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	51040	0	0	0	0	105
SRP_00202	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	54285	0	0	0	0	117
SRP_00241	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	82
SRP_00255	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	47586	0	0	0	0	94
SRP_00260	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	47895	0	0	0	0	100
SRP_00278	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	105
SRP_00322	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	48516	0	0	0	0	109
SRP_00328	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	39621	0	0	0	0	85
SRP_00329	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	39903	0	0	0	0	85
SRP_00339	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	44551	0	0	0	0	94
SRP_00340	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	41328	0	0	0	0	82

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Murlet(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

2. Individual counts for Murlet(seed) [ download as .csv ]

Performance of Carnac(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for Carnac(seed)

2. Individual counts for Carnac(seed) [ download as .csv ]