CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Murlet(seed)		RNASLOpt
MCC	0.556	>	0.479
Average MCC ± 95% Confidence Intervals	0.543 ± 0.095	>	0.472 ± 0.071
Sensitivity	0.366	<	0.466
Positive Predictive Value	0.846	>	0.494
Total TP	840	<	1068
Total TN	1200285	>	1199116
Total FP	205	<	1204
Total FP CONTRA	9	<	217
Total FP INCONS	144	<	877
Total FP COMP	52	<	110
Total FN	1454	>	1226
P-value	5.10776592382e-08

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Performance plots

Comparison of performance of Murlet(seed) and RNASLOpt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(seed) and RNASLOpt).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(seed) and RNASLOpt).
Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(seed) and RNASLOpt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(seed) and RNASLOpt).

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Performance of Murlet(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP	840
Total TN	1200285
Total FP	205
Total FP CONTRA	9
Total FP INCONS	144
Total FP COMP	52
Total FN	1454

Total Scores
MCC	0.556
Average MCC ± 95% Confidence Intervals	0.543 ± 0.095
Sensitivity	0.366
Positive Predictive Value	0.846
Nr of predictions	29

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21321	0	0	0	0	39
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21945	0	0	0	0	39
RFA_00626	rne5 links to Rfam database...	0.81	0.66	1.00	57	56559	4	0	0	4	30
RFA_00627	rne5 links to Rfam database...	0.84	0.70	1.00	61	56892	5	0	0	5	26
RFA_00628	rne5 links to Rfam database...	0.83	0.69	1.00	59	57232	8	0	0	8	27
RFA_00630	rne5 links to Rfam database...	0.82	0.67	1.00	58	56895	4	0	0	4	29
RFA_00639	7SK links to Rfam database...	0.21	0.11	0.40	10	54590	15	4	11	0	77
RFA_00814	R2_retro_el links to Rfam database...	0.75	0.63	0.90	26	25171	4	0	3	1	15
RFA_00815	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	24503	1	0	0	1	13
RFA_00816	R2_retro_el links to Rfam database...	0.75	0.63	0.90	26	23191	4	0	3	1	15
RFA_00817	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	21917	1	0	0	1	13
RFA_00818	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	20273	1	0	0	1	13
RFA_00819	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	27938	0	0	0	0	13
SRP_00079	Plant_SRP links to Rfam database...	0.54	0.33	0.88	29	41872	6	0	4	2	59
SRP_00124	Metazoa_SRP links to Rfam database...	0.15	0.09	0.24	8	37094	27	3	23	1	77
SRP_00182	Plant_SRP links to Rfam database...	0.59	0.35	1.00	35	46021	1	0	0	1	66
SRP_00197	Archaea_SRP links to Rfam database...	0.47	0.28	0.80	28	49420	8	0	7	1	73
SRP_00198	Archaea_SRP links to Rfam database...	0.47	0.27	0.82	28	51006	7	0	6	1	75
SRP_00199	Archaea_SRP links to Rfam database...	0.47	0.24	0.93	25	51013	3	0	2	1	80
SRP_00202	Archaea_SRP links to Rfam database...	0.48	0.25	0.94	29	54254	2	0	2	0	88
SRP_00241	Plant_SRP links to Rfam database...	0.51	0.33	0.79	27	46022	9	0	7	2	55
SRP_00255	Archaea_SRP links to Rfam database...	0.65	0.43	1.00	40	47546	2	0	0	2	54
SRP_00260	Metazoa_SRP links to Rfam database...	0.21	0.14	0.33	14	47852	29	1	28	0	86
SRP_00278	Archaea_SRP links to Rfam database...	0.53	0.30	0.94	31	46023	3	0	2	1	74
SRP_00322	Archaea_SRP links to Rfam database...	0.44	0.25	0.79	27	48482	8	0	7	1	82
SRP_00328	Metazoa_SRP links to Rfam database...	0.49	0.34	0.71	29	39580	16	1	11	4	56
SRP_00329	Metazoa_SRP links to Rfam database...	0.50	0.34	0.73	29	39863	16	0	11	5	56
SRP_00339	Archaea_SRP links to Rfam database...	0.49	0.32	0.77	30	44512	9	0	9	0	64
SRP_00340	Metazoa_SRP links to Rfam database...	0.44	0.27	0.73	22	41298	12	0	8	4	60

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Performance of RNASLOpt - scored lower in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP	1068
Total TN	1199116
Total FP	1204
Total FP CONTRA	217
Total FP INCONS	877
Total FP COMP	110
Total FN	1226

Total Scores
MCC	0.479
Average MCC ± 95% Confidence Intervals	0.472 ± 0.071
Sensitivity	0.466
Positive Predictive Value	0.494
Nr of predictions	29

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.18	0.18	0.18	7	21281	39	4	29	6	32
RFA_00620	Telomerase-cil links to Rfam database...	0.66	0.64	0.68	25	21908	22	2	10	10	14
RFA_00626	rne5 links to Rfam database...	0.68	0.64	0.72	56	56538	30	6	16	8	31
RFA_00627	rne5 links to Rfam database...	0.61	0.60	0.62	52	56869	41	11	21	9	35
RFA_00628	rne5 links to Rfam database...	0.89	0.84	0.95	72	57215	15	0	4	11	14
RFA_00630	rne5 links to Rfam database...	0.69	0.67	0.72	58	56872	32	5	18	9	29
RFA_00639	7SK links to Rfam database...	0.29	0.29	0.29	25	54528	67	12	50	5	62
RFA_00814	R2_retro_el links to Rfam database...	0.51	0.51	0.51	21	25159	29	9	11	9	20
RFA_00815	R2_retro_el links to Rfam database...	0.41	0.41	0.41	17	24490	31	1	23	7	24
RFA_00816	R2_retro_el links to Rfam database...	0.58	0.63	0.53	26	23171	26	13	10	3	15
RFA_00817	R2_retro_el links to Rfam database...	0.24	0.27	0.22	11	21896	42	12	26	4	30
RFA_00818	R2_retro_el links to Rfam database...	0.21	0.22	0.21	9	20258	39	14	20	5	32
RFA_00819	R2_retro_el links to Rfam database...	0.60	0.68	0.53	28	27913	34	16	9	9	13
SRP_00079	Plant_SRP links to Rfam database...	0.62	0.57	0.68	50	41832	24	3	20	1	38
SRP_00124	Metazoa_SRP links to Rfam database...	0.39	0.36	0.43	31	37056	41	8	33	0	54
SRP_00182	Plant_SRP links to Rfam database...	0.54	0.51	0.57	52	45965	39	11	28	0	49
SRP_00197	Archaea_SRP links to Rfam database...	0.23	0.21	0.25	21	49370	64	9	55	0	80
SRP_00198	Archaea_SRP links to Rfam database...	0.41	0.38	0.45	39	50954	47	5	42	0	64
SRP_00199	Archaea_SRP links to Rfam database...	0.24	0.23	0.26	24	50949	67	3	64	0	81
SRP_00202	Archaea_SRP links to Rfam database...	0.52	0.49	0.56	57	54184	44	6	38	0	60
SRP_00241	Plant_SRP links to Rfam database...	0.26	0.27	0.26	22	45970	66	14	50	2	60
SRP_00255	Archaea_SRP links to Rfam database...	0.29	0.30	0.29	28	47489	69	11	58	0	66
SRP_00260	Metazoa_SRP links to Rfam database...	0.69	0.66	0.72	66	47803	28	8	18	2	34
SRP_00278	Archaea_SRP links to Rfam database...	0.68	0.65	0.72	68	45961	29	4	23	2	37
SRP_00322	Archaea_SRP links to Rfam database...	0.57	0.54	0.61	59	48419	38	1	37	0	50
SRP_00328	Metazoa_SRP links to Rfam database...	0.60	0.60	0.61	51	39537	36	7	26	3	34
SRP_00329	Metazoa_SRP links to Rfam database...	0.34	0.32	0.36	27	39829	50	4	43	3	58
SRP_00339	Archaea_SRP links to Rfam database...	0.44	0.43	0.45	40	44462	51	6	43	2	54
SRP_00340	Metazoa_SRP links to Rfam database...	0.30	0.32	0.29	26	41238	64	12	52	0	56

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Murlet(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

2. Individual counts for Murlet(seed) [ download as .csv ]

Performance of RNASLOpt - scored lower in this pairwise comparison

1. Total counts & total scores for RNASLOpt

2. Individual counts for RNASLOpt [ download as .csv ]