CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	Murlet(seed)		RSpredict(seed)
MCC	0.569	>	0.021
Average MCC ± 95% Confidence Intervals	0.550 ± 0.089	>	0.011 ± 0.015
Sensitivity	0.383	>	0.020
Positive Predictive Value	0.845	>	0.024
Total TP	1000	>	52
Total TN	1504247	>	1503299
Total FP	241	<	2140
Total FP CONTRA	15	<	312
Total FP INCONS	169	<	1768
Total FP COMP	57	<	60
Total FN	1608	<	2556
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of Murlet(seed) and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for Murlet(seed) and RSpredict(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for Murlet(seed) and RSpredict(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for Murlet(seed) and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for Murlet(seed) and RSpredict(seed)).

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Performance of Murlet(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

Total Base Pair Counts
Total TP	1000
Total TN	1504247
Total FP	241
Total FP CONTRA	15
Total FP INCONS	169
Total FP COMP	57
Total FN	1608

Total Scores
MCC	0.569
Average MCC ± 95% Confidence Intervals	0.550 ± 0.089
Sensitivity	0.383
Positive Predictive Value	0.845
Nr of predictions	31

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2. Individual counts for Murlet(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21321	0	0	0	0	39
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21945	0	0	0	0	39
RFA_00626	rne5 links to Rfam database...	0.81	0.66	1.00	57	56559	4	0	0	4	30
RFA_00627	rne5 links to Rfam database...	0.84	0.70	1.00	61	56892	5	0	0	5	26
RFA_00628	rne5 links to Rfam database...	0.83	0.69	1.00	59	57232	8	0	0	8	27
RFA_00630	rne5 links to Rfam database...	0.82	0.67	1.00	58	56895	4	0	0	4	29
RFA_00639	7SK links to Rfam database...	0.21	0.11	0.40	10	54590	15	4	11	0	77
RFA_00814	R2_retro_el links to Rfam database...	0.75	0.63	0.90	26	25171	4	0	3	1	15
RFA_00815	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	24503	1	0	0	1	13
RFA_00816	R2_retro_el links to Rfam database...	0.75	0.63	0.90	26	23191	4	0	3	1	15
RFA_00817	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	21917	1	0	0	1	13
RFA_00818	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	20273	1	0	0	1	13
RFA_00819	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	27938	0	0	0	0	13
RFA_00820	bicoid_3 links to Rfam database...	0.71	0.56	0.89	90	151424	13	3	8	2	70
RFA_00830	bicoid_3 links to Rfam database...	0.59	0.45	0.78	70	152538	23	3	17	3	84
SRP_00079	Plant_SRP links to Rfam database...	0.54	0.33	0.88	29	41872	6	0	4	2	59
SRP_00124	Metazoa_SRP links to Rfam database...	0.15	0.09	0.24	8	37094	27	3	23	1	77
SRP_00182	Plant_SRP links to Rfam database...	0.59	0.35	1.00	35	46021	1	0	0	1	66
SRP_00197	Archaea_SRP links to Rfam database...	0.47	0.28	0.80	28	49420	8	0	7	1	73
SRP_00198	Archaea_SRP links to Rfam database...	0.47	0.27	0.82	28	51006	7	0	6	1	75
SRP_00199	Archaea_SRP links to Rfam database...	0.47	0.24	0.93	25	51013	3	0	2	1	80
SRP_00202	Archaea_SRP links to Rfam database...	0.48	0.25	0.94	29	54254	2	0	2	0	88
SRP_00241	Plant_SRP links to Rfam database...	0.51	0.33	0.79	27	46022	9	0	7	2	55
SRP_00255	Archaea_SRP links to Rfam database...	0.65	0.43	1.00	40	47546	2	0	0	2	54
SRP_00260	Metazoa_SRP links to Rfam database...	0.21	0.14	0.33	14	47852	29	1	28	0	86
SRP_00278	Archaea_SRP links to Rfam database...	0.53	0.30	0.94	31	46023	3	0	2	1	74
SRP_00322	Archaea_SRP links to Rfam database...	0.44	0.25	0.79	27	48482	8	0	7	1	82
SRP_00328	Metazoa_SRP links to Rfam database...	0.49	0.34	0.71	29	39580	16	1	11	4	56
SRP_00329	Metazoa_SRP links to Rfam database...	0.50	0.34	0.73	29	39863	16	0	11	5	56
SRP_00339	Archaea_SRP links to Rfam database...	0.49	0.32	0.77	30	44512	9	0	9	0	64
SRP_00340	Metazoa_SRP links to Rfam database...	0.44	0.27	0.73	22	41298	12	0	8	4	60

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP	52
Total TN	1503299
Total FP	2140
Total FP CONTRA	312
Total FP INCONS	1768
Total FP COMP	60
Total FN	2556

Total Scores
MCC	0.021
Average MCC ± 95% Confidence Intervals	0.011 ± 0.015
Sensitivity	0.020
Positive Predictive Value	0.024
Nr of predictions	31

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21295	28	9	17	2	39
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21916	33	2	27	4	39
RFA_00626	rne5 links to Rfam database...	0.00	0.00	0.00	0	56534	83	16	66	1	87
RFA_00627	rne5 links to Rfam database...	0.00	0.00	0.00	0	56869	84	21	63	0	87
RFA_00628	rne5 links to Rfam database...	0.00	0.00	0.00	0	57206	85	25	60	0	86
RFA_00630	rne5 links to Rfam database...	0.07	0.07	0.07	6	56872	79	18	57	4	81
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54546	71	13	56	2	87
RFA_00814	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	25168	36	2	30	4	41
RFA_00815	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	24501	40	5	25	10	41
RFA_00816	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	23193	37	5	22	10	41
RFA_00817	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	21919	34	5	21	8	41
RFA_00818	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	20276	28	2	23	3	41
RFA_00819	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	27928	44	7	31	6	41
RFA_00820	bicoid_3 links to Rfam database...	0.18	0.16	0.20	26	151392	108	18	89	1	134
RFA_00830	bicoid_3 links to Rfam database...	0.14	0.13	0.15	20	152495	117	21	92	4	134
SRP_00079	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	41841	65	9	55	1	88
SRP_00124	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	37067	61	6	55	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	45987	69	10	59	0	101
SRP_00197	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	49364	91	10	81	0	101
SRP_00198	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	50951	89	8	81	0	103
SRP_00199	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	50949	91	6	85	0	105
SRP_00202	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	54195	90	9	81	0	117
SRP_00241	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	45983	73	13	60	0	82
SRP_00255	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	47497	89	17	72	0	94
SRP_00260	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	47824	71	3	68	0	100
SRP_00278	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	45970	86	5	81	0	105
SRP_00322	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	48431	85	9	76	0	109
SRP_00328	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	39557	64	8	56	0	85
SRP_00329	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	39842	61	8	53	0	85
SRP_00339	Archaea_SRP links to Rfam database...	0.00	0.00	0.00	0	44472	79	9	70	0	94
SRP_00340	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	41259	69	13	56	0	82

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of Murlet(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for Murlet(seed)

2. Individual counts for Murlet(seed) [ download as .csv ]

Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

2. Individual counts for RSpredict(seed) [ download as .csv ]