CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PETfold_pre2.0(seed)		RNASampler(20)
MCC	0.756	>	0.594
Average MCC ± 95% Confidence Intervals	0.751 ± 0.032	>	0.585 ± 0.038
Sensitivity	0.682	>	0.461
Positive Predictive Value	0.840	>	0.766
Total TP	4387	>	2969
Total TN	3847702	<	3849050
Total FP	1413	>	1144
Total FP CONTRA	266	>	258
Total FP INCONS	569	<	647
Total FP COMP	578	>	239
Total FN	2050	<	3468
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of PETfold_pre2.0(seed) and RNASampler(20). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and RNASampler(20)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and RNASampler(20)).
Comparison of average Matthews Correlation Coefficients (MCCs) for PETfold_pre2.0(seed) and RNASampler(20). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PETfold_pre2.0(seed) and RNASampler(20)).

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Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

Total Base Pair Counts
Total TP	4387
Total TN	3847702
Total FP	1413
Total FP CONTRA	266
Total FP INCONS	569
Total FP COMP	578
Total FN	2050

Total Scores
MCC	0.756
Average MCC ± 95% Confidence Intervals	0.751 ± 0.032
Sensitivity	0.682
Positive Predictive Value	0.840
Nr of predictions	66

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2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.83	0.79	0.88	70	45371	15	4	6	5	19
ASE_00090	RNaseP_bact_a links to Rfam database...	0.80	0.72	0.89	73	55529	15	4	5	6	28
ASE_00135	RNaseP_bact_a links to Rfam database...	0.63	0.55	0.71	60	63106	27	6	18	3	49
ASE_00153	RNaseP_nuc links to Rfam database...	0.63	0.55	0.71	40	57574	20	3	13	4	33
ASE_00215	RNaseP_bact_a links to Rfam database...	0.60	0.49	0.72	49	48448	21	4	15	2	50
ASE_00305	RNaseP_bact_b links to Rfam database...	0.85	0.84	0.86	71	54532	27	1	11	15	14
ASE_00328	RNaseP_bact_b links to Rfam database...	0.87	0.83	0.90	93	72668	24	2	8	14	19
ASE_00361	RNaseP_bact_a links to Rfam database...	0.71	0.57	0.88	72	75384	15	4	6	5	55
ASE_00427	RNaseP_nuc links to Rfam database...	0.85	0.78	0.92	36	40716	9	0	3	6	10
ASE_00441	RNaseP_bact_a links to Rfam database...	0.69	0.57	0.84	64	64185	18	4	8	6	48
SRP_00006	Metazoa_SRP links to Rfam database...	0.95	0.92	0.99	93	45659	10	0	1	9	8
SRP_00011	Plant_SRP links to Rfam database...	0.82	0.79	0.86	82	46265	21	0	13	8	22
SRP_00015	Plant_SRP links to Rfam database...	0.87	0.84	0.91	83	46269	20	0	8	12	16
SRP_00050	Metazoa_SRP links to Rfam database...	0.97	0.97	0.98	96	44752	9	0	2	7	3
SRP_00066	Metazoa_SRP links to Rfam database...	0.94	0.91	0.98	91	45358	15	0	2	13	9
SRP_00086	Metazoa_SRP links to Rfam database...	0.97	0.96	0.98	96	44155	9	0	2	7	4
SRP_00102	Metazoa_SRP links to Rfam database...	0.96	0.95	0.98	96	44453	9	0	2	7	5
SRP_00103	Metazoa_SRP links to Rfam database...	0.95	0.93	0.98	95	45354	10	0	2	8	7
SRP_00152	Plant_SRP links to Rfam database...	0.89	0.83	0.95	86	45662	17	0	5	12	17
SRP_00171	Metazoa_SRP links to Rfam database...	0.98	0.97	1.00	85	45366	21	0	0	21	3
SRP_00178	Plant_SRP links to Rfam database...	0.91	0.86	0.96	88	45661	15	0	4	11	14
SRP_00179	Plant_SRP links to Rfam database...	0.90	0.85	0.96	89	45963	14	0	4	10	16
SRP_00181	Plant_SRP links to Rfam database...	0.85	0.81	0.89	83	45963	21	0	10	11	19
SRP_00182	Plant_SRP links to Rfam database...	0.88	0.84	0.91	85	45963	17	0	8	9	16
SRP_00188	Plant_SRP links to Rfam database...	0.86	0.82	0.90	65	31053	14	0	7	7	14
SRP_00228	Metazoa_SRP links to Rfam database...	0.97	0.96	0.98	91	45358	14	0	2	12	4
SRP_00317	Metazoa_SRP links to Rfam database...	0.95	0.94	0.96	92	45054	13	0	4	9	6
SRP_00347	Metazoa_SRP links to Rfam database...	0.94	0.93	0.96	89	46572	16	0	4	12	7
SRP_00368	Metazoa_SRP links to Rfam database...	0.96	0.95	0.98	93	43861	12	0	2	10	5
TMR_00017	tmRNA links to Rfam database...	0.72	0.62	0.84	63	67086	20	6	6	8	39
TMR_00018	tmRNA links to Rfam database...	0.65	0.59	0.72	54	64545	29	8	13	8	38
TMR_00042	tmRNA links to Rfam database...	0.68	0.60	0.78	59	62759	23	7	10	6	39
TMR_00046	tmRNA links to Rfam database...	0.47	0.42	0.53	40	62760	41	6	29	6	56
TMR_00048	tmRNA links to Rfam database...	0.68	0.61	0.76	58	64904	24	7	11	6	37
TMR_00080	tmRNA links to Rfam database...	0.55	0.49	0.63	47	70425	35	10	18	7	49
TMR_00082	tmRNA links to Rfam database...	0.59	0.51	0.68	49	67824	32	9	14	9	47
TMR_00123	tmRNA links to Rfam database...	0.72	0.61	0.84	62	66356	21	7	5	9	39
TMR_00137	tmRNA links to Rfam database...	0.63	0.56	0.71	50	61005	32	8	12	12	39
TMR_00142	tmRNA links to Rfam database...	0.63	0.54	0.74	55	70802	27	4	15	8	47
TMR_00207	tmRNA links to Rfam database...	0.68	0.57	0.80	59	72316	24	7	8	9	44
TMR_00257	tmRNA links to Rfam database...	0.72	0.62	0.82	61	67087	22	7	6	9	37
TMR_00271	tmRNA links to Rfam database...	0.62	0.54	0.71	49	64192	32	7	13	12	42
TMR_00332	tmRNA links to Rfam database...	0.69	0.60	0.80	59	67087	25	6	9	10	40
TMR_00366	tmRNA links to Rfam database...	0.63	0.54	0.74	54	67823	28	3	16	9	46
TMR_00378	tmRNA links to Rfam database...	0.65	0.55	0.77	53	67827	26	3	13	10	44
TMR_00404	tmRNA links to Rfam database...	0.58	0.51	0.66	47	67457	35	6	18	11	45
TMR_00427	tmRNA links to Rfam database...	0.68	0.60	0.76	58	67452	26	11	7	8	39
TMR_00443	tmRNA links to Rfam database...	0.72	0.62	0.84	64	67085	19	6	6	7	40
TMR_00451	tmRNA links to Rfam database...	0.56	0.51	0.63	45	63474	37	13	14	10	44
TMR_00458	tmRNA links to Rfam database...	0.66	0.58	0.75	54	63474	29	8	10	11	39
TMR_00469	tmRNA links to Rfam database...	0.71	0.61	0.84	61	64547	20	6	6	8	39
TMR_00472	tmRNA links to Rfam database...	0.68	0.59	0.79	57	64548	23	7	8	8	40
TMR_00519	tmRNA links to Rfam database...	0.64	0.57	0.72	54	63115	29	9	12	8	41
TMR_00520	tmRNA links to Rfam database...	0.68	0.60	0.79	59	63115	25	7	9	9	40
TMR_00522	tmRNA links to Rfam database...	0.65	0.56	0.75	54	63118	28	6	12	10	43
TMR_00528	tmRNA links to Rfam database...	0.64	0.56	0.74	54	63117	28	6	13	9	43
TMR_00540	tmRNA links to Rfam database...	0.65	0.56	0.75	58	73459	25	9	10	6	46
TMR_00568	tmRNA links to Rfam database...	0.76	0.65	0.89	64	60654	17	1	7	9	35
TMR_00571	tmRNA links to Rfam database...	0.78	0.67	0.92	66	60654	16	1	5	10	33
TMR_00580	tmRNA links to Rfam database...	0.74	0.61	0.90	61	60658	17	2	5	10	39
TMR_00584	tmRNA links to Rfam database...	0.77	0.65	0.91	63	61006	14	2	4	8	34
TMR_00586	tmRNA links to Rfam database...	0.74	0.64	0.85	62	61002	19	5	6	8	35
TMR_00616	tmRNA links to Rfam database...	0.65	0.56	0.75	55	67088	24	8	10	6	44
TMR_00699	tmRNA links to Rfam database...	0.68	0.58	0.80	59	67087	23	6	9	8	43
TMR_00702	tmRNA links to Rfam database...	0.64	0.55	0.74	55	67087	27	3	16	8	45
TMR_00703	tmRNA links to Rfam database...	0.68	0.60	0.79	59	67453	23	7	9	7	40

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Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	2969
Total TN	3849050
Total FP	1144
Total FP CONTRA	258
Total FP INCONS	647
Total FP COMP	239
Total FN	3468

Total Scores
MCC	0.594
Average MCC ± 95% Confidence Intervals	0.585 ± 0.038
Sensitivity	0.461
Positive Predictive Value	0.766
Nr of predictions	66

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PETfold_pre2.0(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PETfold_pre2.0(seed)

2. Individual counts for PETfold_pre2.0(seed) [ download as .csv ]

Performance of RNASampler(20) - scored lower in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]