CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

Home

Methods

Datasets

Rankings

RNA 2D Atlas

Help

FAQ

Contact us

RSS feeds

Twitter

Overview

Metric	PPfold(20)		NanoFolder
MCC	0.722	>	0.152
Average MCC ± 95% Confidence Intervals	0.714 ± 0.031	>	0.151 ± 0.029
Sensitivity	0.614	>	0.176
Positive Predictive Value	0.849	>	0.135
Total TP	3487	>	997
Total TN	3198595	>	3195319
Total FP	866	<	6513
Total FP CONTRA	131	<	891
Total FP INCONS	488	<	5494
Total FP COMP	247	>	128
Total FN	2192	<	4682
P-value	3.56938820447e-08

^top

Performance plots

Comparison of performance of PPfold(20) and NanoFolder. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(20) and NanoFolder).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(20) and NanoFolder).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(20) and NanoFolder. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(20) and NanoFolder).

^top

Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

Total Base Pair Counts
Total TP	3487
Total TN	3198595
Total FP	866
Total FP CONTRA	131
Total FP INCONS	488
Total FP COMP	247
Total FN	2192

Total Scores
MCC	0.722
Average MCC ± 95% Confidence Intervals	0.714 ± 0.031
Sensitivity	0.614
Positive Predictive Value	0.849
Nr of predictions	55

^top

2. Individual counts for PPfold(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00083	RNaseP_bact_a links to Rfam database...	0.74	0.62	0.89	68	62405	13	3	5	5	42
ASE_00185	RNaseP_bact_a links to Rfam database...	0.68	0.52	0.90	66	73463	12	3	4	5	62
ASE_00190	RNaseP_bact_b links to Rfam database...	0.75	0.64	0.87	58	45384	12	1	8	3	32
ASE_00221	RNaseP_bact_a links to Rfam database...	0.85	0.78	0.93	91	64522	10	1	6	3	26
ASE_00228	RNaseP_bact_a links to Rfam database...	0.75	0.69	0.83	59	46900	16	2	10	4	27
ASE_00229	RNaseP_bact_a links to Rfam database...	0.88	0.79	0.97	69	42415	5	2	0	3	18
ASE_00231	RNaseP_bact_a links to Rfam database...	0.67	0.57	0.77	55	47824	22	1	15	6	41
ASE_00234	RNaseP_bact_a links to Rfam database...	0.66	0.53	0.83	68	75384	20	6	8	6	61
ASE_00238	RNaseP_bact_a links to Rfam database...	0.67	0.56	0.80	64	64181	22	5	11	6	50
ASE_00248	RNaseP_bact_a links to Rfam database...	0.86	0.81	0.91	92	62380	13	1	8	4	22
ASE_00254	RNaseP_bact_a links to Rfam database...	0.85	0.77	0.94	63	36789	8	2	2	4	19
ASE_00255	RNaseP_bact_a links to Rfam database...	0.62	0.55	0.71	72	74589	32	4	26	2	58
ASE_00257	RNaseP_bact_a links to Rfam database...	0.73	0.65	0.82	63	50963	17	4	10	3	34
ASE_00267	RNaseP_bact_a links to Rfam database...	0.84	0.77	0.91	68	45075	13	2	5	6	20
ASE_00270	RNaseP_bact_a links to Rfam database...	0.58	0.43	0.79	55	72320	19	2	13	4	73
ASE_00274	RNaseP_bact_a links to Rfam database...	0.68	0.60	0.78	62	55531	21	5	13	3	41
ASE_00279	RNaseP_bact_a links to Rfam database...	0.79	0.69	0.90	70	53223	11	3	5	3	31
ASE_00285	RNaseP_bact_a links to Rfam database...	0.70	0.55	0.91	67	68932	11	2	5	4	55
ASE_00287	RNaseP_bact_a links to Rfam database...	0.69	0.60	0.79	62	54868	20	1	15	4	41
ASE_00294	RNaseP_bact_a links to Rfam database...	0.72	0.57	0.92	97	114375	13	2	7	4	74
ASE_00298	RNaseP_bact_a links to Rfam database...	0.72	0.61	0.85	69	67447	15	3	9	3	44
ASE_00318	RNaseP_bact_b links to Rfam database...	0.75	0.66	0.85	78	80108	21	1	13	7	40
ASE_00321	RNaseP_bact_b links to Rfam database...	0.77	0.74	0.81	65	54535	23	1	14	8	23
ASE_00335	RNaseP_bact_b links to Rfam database...	0.77	0.70	0.85	81	75371	25	1	13	11	35
ASE_00340	RNaseP_bact_a links to Rfam database...	0.75	0.67	0.85	57	45989	17	1	9	7	28
ASE_00367	RNaseP_bact_a links to Rfam database...	0.85	0.79	0.91	68	42996	11	2	5	4	18
ASE_00372	RNaseP_bact_a links to Rfam database...	0.76	0.65	0.88	65	51929	15	1	8	6	35
ASE_00376	RNaseP_bact_a links to Rfam database...	0.73	0.63	0.85	66	56875	15	1	11	3	39
ASE_00377	RNaseP_bact_a links to Rfam database...	0.76	0.65	0.88	70	57550	13	3	7	3	37
ASE_00386	RNaseP_bact_a links to Rfam database...	0.79	0.71	0.88	68	50326	12	2	7	3	28
ASE_00393	RNaseP_bact_a links to Rfam database...	0.74	0.68	0.82	63	47818	19	1	13	5	30
ASE_00412	RNaseP_bact_a links to Rfam database...	0.62	0.54	0.71	57	58231	28	5	18	5	48
ASE_00413	RNaseP_bact_a links to Rfam database...	0.76	0.73	0.79	59	44476	23	4	12	7	22
ASE_00416	RNaseP_bact_a links to Rfam database...	0.74	0.66	0.82	84	77319	23	4	14	5	43
ASE_00422	RNaseP_bact_a links to Rfam database...	0.82	0.73	0.91	69	46895	13	1	6	6	25
ASE_00427	RNaseP_nuc links to Rfam database...	0.35	0.30	0.40	14	40720	29	9	12	8	32
ASE_00428	RNaseP_bact_a links to Rfam database...	0.75	0.68	0.83	85	76533	21	4	14	3	40
ASE_00430	RNaseP_bact_a links to Rfam database...	0.75	0.66	0.85	64	46896	14	1	10	3	33
ASE_00437	RNaseP_bact_a links to Rfam database...	0.58	0.50	0.69	67	79304	33	1	29	3	68
ASE_00451	RNaseP_bact_a links to Rfam database...	0.81	0.73	0.91	91	70776	12	1	8	3	34
SRP_00103	Metazoa_SRP links to Rfam database...	0.82	0.73	0.93	74	45371	9	0	6	3	28
SRP_00173	Bacteria_large_SRP links to Rfam database...	0.52	0.30	0.90	27	38196	3	0	3	0	63
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.53	0.31	0.90	27	36285	4	0	3	1	59
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.29	0.13	0.69	11	36299	5	0	5	0	77
SRP_00317	Metazoa_SRP links to Rfam database...	0.92	0.87	0.98	85	45063	7	0	2	5	13
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.54	0.32	0.91	29	35479	4	0	3	1	62
TMR_00123	tmRNA links to Rfam database...	0.68	0.52	0.88	53	66370	12	1	6	5	48
TMR_00399	tmRNA links to Rfam database...	0.70	0.61	0.81	57	64910	21	6	7	8	37
TMR_00443	tmRNA links to Rfam database...	0.76	0.63	0.93	65	67091	11	2	3	6	39
TMR_00469	tmRNA links to Rfam database...	0.73	0.61	0.88	61	64551	11	4	4	3	39
TMR_00519	tmRNA links to Rfam database...	0.63	0.54	0.74	51	63121	25	7	11	7	44
TMR_00528	tmRNA links to Rfam database...	0.62	0.51	0.75	49	63125	20	5	11	4	48
TMR_00571	tmRNA links to Rfam database...	0.77	0.68	0.88	67	60650	15	2	7	6	32
TMR_00584	tmRNA links to Rfam database...	0.78	0.66	0.93	64	61006	13	2	3	8	33
TMR_00703	tmRNA links to Rfam database...	0.71	0.59	0.87	58	67461	14	3	6	5	41

^top

Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

Total Base Pair Counts
Total TP	997
Total TN	3195319
Total FP	6513
Total FP CONTRA	891
Total FP INCONS	5494
Total FP COMP	128
Total FN	4682

Total Scores
MCC	0.152
Average MCC ± 95% Confidence Intervals	0.151 ± 0.029
Sensitivity	0.176
Positive Predictive Value	0.135
Nr of predictions	55

^top

2. Individual counts for NanoFolder [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00083	RNaseP_bact_a links to Rfam database...	0.22	0.25	0.20	27	62347	108	12	95	1	83
ASE_00185	RNaseP_bact_a links to Rfam database...	0.17	0.19	0.16	24	73382	134	14	116	4	104
ASE_00190	RNaseP_bact_b links to Rfam database...	0.24	0.28	0.21	25	45334	93	14	78	1	65
ASE_00221	RNaseP_bact_a links to Rfam database...	0.20	0.21	0.18	25	64484	112	10	101	1	92
ASE_00228	RNaseP_bact_a links to Rfam database...	0.05	0.06	0.04	5	46858	109	17	91	1	81
ASE_00229	RNaseP_bact_a links to Rfam database...	0.12	0.14	0.11	12	42380	97	12	82	3	75
ASE_00231	RNaseP_bact_a links to Rfam database...	0.37	0.42	0.33	40	47773	84	17	65	2	56
ASE_00234	RNaseP_bact_a links to Rfam database...	0.25	0.27	0.23	35	75315	117	10	106	1	94
ASE_00238	RNaseP_bact_a links to Rfam database...	0.26	0.30	0.23	34	64111	119	18	98	3	80
ASE_00248	RNaseP_bact_a links to Rfam database...	0.13	0.15	0.12	17	62340	124	9	115	0	97
ASE_00254	RNaseP_bact_a links to Rfam database...	0.15	0.16	0.14	13	36761	88	3	79	6	69
ASE_00255	RNaseP_bact_a links to Rfam database...	0.11	0.12	0.10	16	74530	146	16	129	1	114
ASE_00257	RNaseP_bact_a links to Rfam database...	0.37	0.42	0.33	41	50917	85	15	67	3	56
ASE_00267	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	45036	115	9	105	1	88
ASE_00270	RNaseP_bact_a links to Rfam database...	0.19	0.21	0.17	27	72232	132	14	117	1	101
ASE_00274	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	55487	126	12	112	2	103
ASE_00279	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	16	53177	109	16	92	1	85
ASE_00285	RNaseP_bact_a links to Rfam database...	0.34	0.36	0.31	44	68866	98	14	82	2	78
ASE_00287	RNaseP_bact_a links to Rfam database...	0.15	0.17	0.14	17	54824	107	14	91	2	86
ASE_00294	RNaseP_bact_a links to Rfam database...	0.12	0.13	0.12	23	114287	172	11	160	1	148
ASE_00298	RNaseP_bact_a links to Rfam database...	0.09	0.10	0.08	11	67389	129	8	120	1	102
ASE_00318	RNaseP_bact_b links to Rfam database...	0.03	0.04	0.03	5	80039	156	21	135	0	113
ASE_00321	RNaseP_bact_b links to Rfam database...	0.11	0.14	0.09	12	54484	122	22	97	3	76
ASE_00335	RNaseP_bact_b links to Rfam database...	0.10	0.12	0.09	14	75304	151	22	126	3	102
ASE_00340	RNaseP_bact_a links to Rfam database...	0.06	0.07	0.05	6	45943	110	13	94	3	79
ASE_00367	RNaseP_bact_a links to Rfam database...	0.08	0.09	0.07	8	42960	110	10	93	7	78
ASE_00372	RNaseP_bact_a links to Rfam database...	0.17	0.20	0.15	20	51871	113	19	93	1	80
ASE_00376	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	56822	136	9	122	5	105
ASE_00377	RNaseP_bact_a links to Rfam database...	0.25	0.27	0.23	29	57505	98	10	86	2	78
ASE_00386	RNaseP_bact_a links to Rfam database...	0.14	0.16	0.13	15	50284	106	9	95	2	81
ASE_00393	RNaseP_bact_a links to Rfam database...	0.31	0.35	0.27	33	47773	90	18	71	1	60
ASE_00412	RNaseP_bact_a links to Rfam database...	0.15	0.17	0.14	18	58183	111	14	96	1	87
ASE_00413	RNaseP_bact_a links to Rfam database...	0.08	0.10	0.07	8	44438	108	19	86	3	73
ASE_00416	RNaseP_bact_a links to Rfam database...	0.39	0.43	0.35	54	77267	103	18	82	3	73
ASE_00422	RNaseP_bact_a links to Rfam database...	0.28	0.31	0.25	29	46856	87	9	77	1	65
ASE_00427	RNaseP_nuc links to Rfam database...	0.06	0.09	0.04	4	40651	105	35	65	5	42
ASE_00428	RNaseP_bact_a links to Rfam database...	0.24	0.26	0.22	33	76483	121	13	107	1	92
ASE_00430	RNaseP_bact_a links to Rfam database...	0.16	0.18	0.14	17	46852	102	10	92	0	80
ASE_00437	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	79238	164	12	151	1	135
ASE_00451	RNaseP_bact_a links to Rfam database...	0.20	0.22	0.19	27	70731	118	8	110	0	98
SRP_00103	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45319	132	14	118	0	102
SRP_00173	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	38104	124	13	109	2	90
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.21	0.24	0.18	21	36200	97	19	75	3	65
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.14	0.17	0.12	15	36189	112	18	93	1	73
SRP_00317	Metazoa_SRP links to Rfam database...	0.14	0.16	0.12	16	45018	116	16	100	0	82
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.42	0.46	0.38	42	35400	70	15	54	1	49
TMR_00123	tmRNA links to Rfam database...	0.19	0.23	0.16	23	66283	126	20	104	2	78
TMR_00399	tmRNA links to Rfam database...	0.20	0.26	0.16	24	64833	130	38	85	7	70
TMR_00443	tmRNA links to Rfam database...	0.17	0.20	0.15	21	67018	126	24	98	4	83
TMR_00469	tmRNA links to Rfam database...	0.10	0.12	0.08	12	64469	145	27	112	6	88
TMR_00519	tmRNA links to Rfam database...	0.04	0.05	0.03	5	63046	141	33	106	2	90
TMR_00528	tmRNA links to Rfam database...	0.13	0.15	0.11	15	63051	131	20	104	7	82
TMR_00571	tmRNA links to Rfam database...	0.05	0.06	0.04	6	60577	149	19	124	6	93
TMR_00584	tmRNA links to Rfam database...	0.01	0.01	0.01	1	60922	159	33	119	7	96
TMR_00703	tmRNA links to Rfam database...	0.10	0.12	0.08	12	67376	140	26	114	0	87

^top

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(20) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(20)

2. Individual counts for PPfold(20) [ download as .csv ]

Performance of NanoFolder - scored lower in this pairwise comparison

1. Total counts & total scores for NanoFolder

2. Individual counts for NanoFolder [ download as .csv ]