CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	PPfold(seed)		Afold
MCC	0.756	>	0.627
Average MCC ± 95% Confidence Intervals	0.782 ± 0.089	>	0.614 ± 0.101
Sensitivity	0.714	>	0.639
Positive Predictive Value	0.802	>	0.616
Total TP	950	>	851
Total TN	730274	>	730078
Total FP	341	<	678
Total FP CONTRA	34	<	124
Total FP INCONS	201	<	406
Total FP COMP	106	<	148
Total FN	381	<	480
P-value	2.78993384543e-08

Comparison of performance of PPfold(seed) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and Afold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and Afold).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and Afold).

Total Scores
MCC	0.756
Average MCC ± 95% Confidence Intervals	0.782 ± 0.089
Sensitivity	0.714
Positive Predictive Value	0.802
Nr of predictions	17

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

Total Scores
MCC	0.627
Average MCC ± 95% Confidence Intervals	0.614 ± 0.101
Sensitivity	0.639
Positive Predictive Value	0.616
Nr of predictions	17

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.89	0.86	0.93	75	56535	31	2	4	25	12
RFA_00627	rne5 links to Rfam database...	0.48	0.47	0.48	41	56868	50	10	34	6	46
RFA_00628	rne5 links to Rfam database...	0.83	0.80	0.85	69	57210	38	1	11	26	17
RFA_00630	rne5 links to Rfam database...	0.60	0.60	0.60	52	56866	46	8	27	11	35
RFA_00814	R2_retro_el links to Rfam database...	0.35	0.37	0.33	15	25155	42	7	23	12	26
RFA_00816	R2_retro_el links to Rfam database...	0.59	0.66	0.53	27	23169	33	13	11	9	14
RFA_00818	R2_retro_el links to Rfam database...	0.19	0.22	0.17	9	20247	48	19	26	3	32
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	32	0	1	31	2
SRP_00079	Plant_SRP links to Rfam database...	0.52	0.55	0.50	48	41809	53	8	40	5	40
SRP_00099	Plant_SRP links to Rfam database...	0.57	0.57	0.57	54	44755	43	5	36	2	41
SRP_00124	Metazoa_SRP links to Rfam database...	0.53	0.52	0.55	44	37048	38	5	31	2	41
SRP_00182	Plant_SRP links to Rfam database...	0.76	0.73	0.79	74	45962	21	3	17	1	27
SRP_00241	Plant_SRP links to Rfam database...	0.54	0.59	0.51	48	45961	50	11	36	3	34
SRP_00252	Metazoa_SRP links to Rfam database...	0.62	0.64	0.59	57	49045	42	12	27	3	32
SRP_00253	Metazoa_SRP links to Rfam database...	0.61	0.63	0.59	57	49359	44	7	32	5	33
SRP_00257	Metazoa_SRP links to Rfam database...	0.85	0.87	0.84	94	50928	20	4	14	2	14
SRP_00340	Metazoa_SRP links to Rfam database...	0.55	0.59	0.52	48	41235	47	9	36	2	34

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.