CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		CRWrnafold
MCC	0.716	>	0.499
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077	>	0.465 ± 0.099
Sensitivity	0.652	>	0.509
Positive Predictive Value	0.787	>	0.491
Total TP	1226	>	956
Total TN	1050327	>	1049936
Total FP	467	<	1158
Total FP CONTRA	48	<	207
Total FP INCONS	283	<	785
Total FP COMP	136	<	166
Total FN	653	<	923
P-value	5.10776592382e-08

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Performance plots

Comparison of performance of PPfold(seed) and CRWrnafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and CRWrnafold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and CRWrnafold).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and CRWrnafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and CRWrnafold).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1226
Total TN	1050327
Total FP	467
Total FP CONTRA	48
Total FP INCONS	283
Total FP COMP	136
Total FN	653

Total Scores
MCC	0.716
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077
Sensitivity	0.652
Positive Predictive Value	0.787
Nr of predictions	23

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00805	RNAIII links to Rfam database...	0.46	0.21	1.00	32	133354	0	0	0	0	118
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

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Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP	956
Total TN	1049936
Total FP	1158
Total FP CONTRA	207
Total FP INCONS	785
Total FP COMP	166
Total FN	923

Total Scores
MCC	0.499
Average MCC ± 95% Confidence Intervals	0.465 ± 0.099
Sensitivity	0.509
Positive Predictive Value	0.491
Nr of predictions	23

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.64	0.63	0.65	55	56532	42	8	21	13	32
RFA_00627	rne5 links to Rfam database...	0.65	0.63	0.67	55	56871	42	6	21	15	32
RFA_00628	rne5 links to Rfam database...	0.89	0.85	0.94	73	57213	30	0	5	25	13
RFA_00630	rne5 links to Rfam database...	0.57	0.57	0.57	50	56865	51	12	26	13	37
RFA_00805	RNAIII links to Rfam database...	0.48	0.48	0.49	72	133238	87	7	69	11	78
RFA_00814	R2_retro_el links to Rfam database...	0.24	0.27	0.21	11	25148	48	10	31	7	30
RFA_00816	R2_retro_el links to Rfam database...	0.21	0.24	0.19	10	23166	50	20	24	6	31
RFA_00817	R2_retro_el links to Rfam database...	0.10	0.12	0.08	5	21883	57	17	40	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	20249	56	19	33	4	41
RFA_00819	R2_retro_el links to Rfam database...	0.44	0.44	0.44	18	27925	57	0	23	34	23
SRP_00079	Plant_SRP links to Rfam database...	0.47	0.47	0.48	41	41819	53	3	42	8	47
SRP_00099	Plant_SRP links to Rfam database...	0.61	0.63	0.59	60	44749	44	6	35	3	35
SRP_00124	Metazoa_SRP links to Rfam database...	0.30	0.29	0.30	25	37046	57	8	49	0	60
SRP_00182	Plant_SRP links to Rfam database...	0.72	0.72	0.72	73	45954	32	9	20	3	28
SRP_00241	Plant_SRP links to Rfam database...	0.54	0.57	0.51	47	45963	48	17	29	2	35
SRP_00252	Metazoa_SRP links to Rfam database...	0.27	0.28	0.26	25	49045	74	12	59	3	64
SRP_00253	Metazoa_SRP links to Rfam database...	0.34	0.37	0.32	33	49353	75	8	61	6	57
SRP_00257	Metazoa_SRP links to Rfam database...	0.81	0.79	0.83	85	50938	20	5	12	3	23
SRP_00260	Metazoa_SRP links to Rfam database...	0.73	0.73	0.74	73	47796	28	7	19	2	27
SRP_00328	Metazoa_SRP links to Rfam database...	0.55	0.55	0.55	47	39536	41	8	30	3	38
SRP_00329	Metazoa_SRP links to Rfam database...	0.25	0.25	0.25	21	39818	65	10	54	1	64
SRP_00331	Metazoa_SRP links to Rfam database...	0.41	0.41	0.42	36	37589	51	7	43	1	51
SRP_00340	Metazoa_SRP links to Rfam database...	0.48	0.50	0.47	41	41240	50	8	39	3	41

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

2. Individual counts for CRWrnafold [ download as .csv ]