CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		CentroidHomfold‑LAST
MCC	0.735	>	0.723
Average MCC ± 95% Confidence Intervals	0.762 ± 0.075	>	0.726 ± 0.063
Sensitivity	0.691	>	0.641
Positive Predictive Value	0.783	<	0.817
Total TP	1194	>	1108
Total TN	916973	<	917142
Total FP	467	>	329
Total FP CONTRA	48	<	49
Total FP INCONS	283	>	199
Total FP COMP	136	>	81
Total FN	535	<	621
P-value	6.02521692575e-08

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Performance plots

Comparison of performance of PPfold(seed) and CentroidHomfold-LAST. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and CentroidHomfold‑LAST).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and CentroidHomfold‑LAST).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and CentroidHomfold-LAST. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and CentroidHomfold‑LAST).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1194
Total TN	916973
Total FP	467
Total FP CONTRA	48
Total FP INCONS	283
Total FP COMP	136
Total FN	535

Total Scores
MCC	0.735
Average MCC ± 95% Confidence Intervals	0.762 ± 0.075
Sensitivity	0.691
Positive Predictive Value	0.783
Nr of predictions	22

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

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Performance of CentroidHomfold‑LAST - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

Total Base Pair Counts
Total TP	1108
Total TN	917142
Total FP	329
Total FP CONTRA	49
Total FP INCONS	199
Total FP COMP	81
Total FN	621

Total Scores
MCC	0.723
Average MCC ± 95% Confidence Intervals	0.726 ± 0.063
Sensitivity	0.641
Positive Predictive Value	0.817
Nr of predictions	22

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2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.85	0.79	0.92	69	56541	13	1	5	7	18
RFA_00627	rne5 links to Rfam database...	0.86	0.75	0.98	65	56887	13	0	1	12	22
RFA_00628	rne5 links to Rfam database...	0.86	0.78	0.94	67	57220	7	1	3	3	19
RFA_00630	rne5 links to Rfam database...	0.87	0.83	0.92	72	56875	10	1	5	4	15
RFA_00814	R2_retro_el links to Rfam database...	0.96	0.93	1.00	38	25162	6	0	0	6	3
RFA_00816	R2_retro_el links to Rfam database...	0.80	0.63	1.00	26	23194	1	0	0	1	15
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.59	0.80	24	21915	9	2	4	3	17
RFA_00818	R2_retro_el links to Rfam database...	0.57	0.54	0.61	22	20265	18	8	6	4	19
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.93	0.97	38	27927	15	0	1	14	3
SRP_00079	Plant_SRP links to Rfam database...	0.73	0.67	0.79	59	41830	21	3	13	5	29
SRP_00099	Plant_SRP links to Rfam database...	0.65	0.55	0.78	52	44783	16	3	12	1	43
SRP_00124	Metazoa_SRP links to Rfam database...	0.39	0.18	0.88	15	37111	2	0	2	0	70
SRP_00182	Plant_SRP links to Rfam database...	0.83	0.75	0.93	76	45974	8	0	6	2	25
SRP_00241	Plant_SRP links to Rfam database...	0.65	0.51	0.82	42	46005	10	0	9	1	40
SRP_00252	Metazoa_SRP links to Rfam database...	0.56	0.52	0.61	46	49066	31	5	24	2	43
SRP_00253	Metazoa_SRP links to Rfam database...	0.63	0.63	0.63	57	49364	39	6	28	5	33
SRP_00257	Metazoa_SRP links to Rfam database...	0.83	0.74	0.93	80	50954	8	3	3	2	28
SRP_00260	Metazoa_SRP links to Rfam database...	0.76	0.74	0.78	74	47800	23	4	17	2	26
SRP_00328	Metazoa_SRP links to Rfam database...	0.67	0.66	0.69	56	39540	29	7	18	4	29
SRP_00329	Metazoa_SRP links to Rfam database...	0.64	0.61	0.68	52	39826	28	4	21	3	33
SRP_00331	Metazoa_SRP links to Rfam database...	0.60	0.53	0.69	46	37608	21	1	20	0	41
SRP_00340	Metazoa_SRP links to Rfam database...	0.61	0.39	0.97	32	41295	1	0	1	0	50

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of CentroidHomfold‑LAST - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidHomfold‑LAST

2. Individual counts for CentroidHomfold‑LAST [ download as .csv ]