CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		Contrafold
MCC	0.716	>	0.654
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077	>	0.638 ± 0.080
Sensitivity	0.652	<	0.661
Positive Predictive Value	0.787	>	0.648
Total TP	1226	<	1242
Total TN	1050327	>	1049966
Total FP	467	<	876
Total FP CONTRA	48	<	139
Total FP INCONS	283	<	537
Total FP COMP	136	<	200
Total FN	653	>	637
P-value	4.98172311752e-08

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Performance plots

Comparison of performance of PPfold(seed) and Contrafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and Contrafold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and Contrafold).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and Contrafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and Contrafold).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1226
Total TN	1050327
Total FP	467
Total FP CONTRA	48
Total FP INCONS	283
Total FP COMP	136
Total FN	653

Total Scores
MCC	0.716
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077
Sensitivity	0.652
Positive Predictive Value	0.787
Nr of predictions	23

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00805	RNAIII links to Rfam database...	0.46	0.21	1.00	32	133354	0	0	0	0	118
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

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Performance of Contrafold - scored lower in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP	1242
Total TN	1049966
Total FP	876
Total FP CONTRA	139
Total FP INCONS	537
Total FP COMP	200
Total FN	637

Total Scores
MCC	0.654
Average MCC ± 95% Confidence Intervals	0.638 ± 0.080
Sensitivity	0.661
Positive Predictive Value	0.648
Nr of predictions	23

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.91	0.87	0.94	76	56535	26	1	4	21	11
RFA_00627	rne5 links to Rfam database...	0.86	0.83	0.89	72	56872	28	0	9	19	15
RFA_00628	rne5 links to Rfam database...	0.91	0.88	0.94	76	57210	25	0	5	20	10
RFA_00630	rne5 links to Rfam database...	0.77	0.77	0.77	67	56866	34	6	14	14	20
RFA_00805	RNAIII links to Rfam database...	0.83	0.74	0.93	111	133266	19	1	8	10	39
RFA_00814	R2_retro_el links to Rfam database...	0.79	0.78	0.80	32	25160	19	1	7	11	9
RFA_00816	R2_retro_el links to Rfam database...	0.72	0.73	0.71	30	23178	20	8	4	8	11
RFA_00817	R2_retro_el links to Rfam database...	0.11	0.12	0.10	5	21893	47	12	35	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.57	0.61	0.53	25	20254	32	11	11	10	16
RFA_00819	R2_retro_el links to Rfam database...	0.46	0.46	0.45	19	27924	47	3	20	24	22
SRP_00079	Plant_SRP links to Rfam database...	0.62	0.63	0.63	55	41817	43	3	30	10	33
SRP_00099	Plant_SRP links to Rfam database...	0.62	0.62	0.62	59	44755	37	7	29	1	36
SRP_00124	Metazoa_SRP links to Rfam database...	0.63	0.62	0.63	53	37044	38	3	28	7	32
SRP_00182	Plant_SRP links to Rfam database...	0.58	0.58	0.58	59	45955	45	10	32	3	42
SRP_00241	Plant_SRP links to Rfam database...	0.51	0.55	0.47	45	45961	53	14	36	3	37
SRP_00252	Metazoa_SRP links to Rfam database...	0.54	0.56	0.52	50	49044	53	7	40	6	39
SRP_00253	Metazoa_SRP links to Rfam database...	0.47	0.49	0.44	44	49356	61	9	46	6	46
SRP_00257	Metazoa_SRP links to Rfam database...	0.86	0.85	0.88	92	50935	22	0	13	9	16
SRP_00260	Metazoa_SRP links to Rfam database...	0.71	0.74	0.69	74	47787	37	6	28	3	26
SRP_00328	Metazoa_SRP links to Rfam database...	0.60	0.62	0.58	53	39530	41	10	28	3	32
SRP_00329	Metazoa_SRP links to Rfam database...	0.59	0.61	0.58	52	39813	43	6	32	5	33
SRP_00331	Metazoa_SRP links to Rfam database...	0.52	0.54	0.50	47	37581	50	10	37	3	40
SRP_00340	Metazoa_SRP links to Rfam database...	0.51	0.56	0.47	46	41230	56	11	41	4	36

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of Contrafold - scored lower in this pairwise comparison

1. Total counts & total scores for Contrafold

2. Individual counts for Contrafold [ download as .csv ]