CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		IPknot
MCC	0.716	>	0.688
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077	>	0.695 ± 0.076
Sensitivity	0.652	<	0.673
Positive Predictive Value	0.787	>	0.705
Total TP	1226	<	1264
Total TN	1050327	>	1050090
Total FP	467	<	659
Total FP CONTRA	48	<	112
Total FP INCONS	283	<	418
Total FP COMP	136	>	129
Total FN	653	>	615
P-value	7.95107997107e-08

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Performance plots

Comparison of performance of PPfold(seed) and IPknot. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and IPknot).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and IPknot).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and IPknot. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and IPknot).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1226
Total TN	1050327
Total FP	467
Total FP CONTRA	48
Total FP INCONS	283
Total FP COMP	136
Total FN	653

Total Scores
MCC	0.716
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077
Sensitivity	0.652
Positive Predictive Value	0.787
Nr of predictions	23

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00805	RNAIII links to Rfam database...	0.46	0.21	1.00	32	133354	0	0	0	0	118
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

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Performance of IPknot - scored lower in this pairwise comparison

1. Total counts & total scores for IPknot

Total Base Pair Counts
Total TP	1264
Total TN	1050090
Total FP	659
Total FP CONTRA	112
Total FP INCONS	418
Total FP COMP	129
Total FN	615

Total Scores
MCC	0.688
Average MCC ± 95% Confidence Intervals	0.695 ± 0.076
Sensitivity	0.673
Positive Predictive Value	0.705
Nr of predictions	23

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2. Individual counts for IPknot [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.89	0.85	0.94	74	56537	14	0	5	9	13
RFA_00627	rne5 links to Rfam database...	0.69	0.66	0.73	57	56875	35	4	17	14	30
RFA_00628	rne5 links to Rfam database...	0.95	0.90	1.00	77	57214	14	0	0	14	9
RFA_00630	rne5 links to Rfam database...	0.82	0.75	0.89	65	56880	14	0	8	6	22
RFA_00805	RNAIII links to Rfam database...	0.65	0.55	0.75	83	133276	35	1	26	8	67
RFA_00814	R2_retro_el links to Rfam database...	0.89	0.88	0.90	36	25160	11	0	4	7	5
RFA_00816	R2_retro_el links to Rfam database...	0.82	0.85	0.80	35	23176	12	8	1	3	6
RFA_00817	R2_retro_el links to Rfam database...	0.23	0.24	0.22	10	21900	38	11	24	3	31
RFA_00818	R2_retro_el links to Rfam database...	0.69	0.68	0.70	28	20261	15	9	3	3	13
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	26	0	1	25	2
SRP_00079	Plant_SRP links to Rfam database...	0.67	0.66	0.68	58	41820	33	3	24	6	30
SRP_00099	Plant_SRP links to Rfam database...	0.59	0.59	0.60	56	44757	38	6	31	1	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.86	0.81	0.92	69	37053	10	0	6	4	16
SRP_00182	Plant_SRP links to Rfam database...	0.75	0.73	0.76	74	45959	25	3	20	2	27
SRP_00241	Plant_SRP links to Rfam database...	0.57	0.60	0.54	49	45965	44	12	30	2	33
SRP_00252	Metazoa_SRP links to Rfam database...	0.51	0.51	0.51	45	49053	47	7	36	4	44
SRP_00253	Metazoa_SRP links to Rfam database...	0.51	0.52	0.51	47	49362	51	9	37	5	43
SRP_00257	Metazoa_SRP links to Rfam database...	0.83	0.81	0.85	88	50937	17	4	11	2	20
SRP_00260	Metazoa_SRP links to Rfam database...	0.75	0.74	0.76	74	47798	25	4	19	2	26
SRP_00328	Metazoa_SRP links to Rfam database...	0.65	0.65	0.66	55	39538	29	8	20	1	30
SRP_00329	Metazoa_SRP links to Rfam database...	0.63	0.61	0.65	52	39823	31	5	23	3	33
SRP_00331	Metazoa_SRP links to Rfam database...	0.52	0.53	0.51	46	37584	47	9	36	2	41
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.57	0.51	47	41236	48	9	36	3	35

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of IPknot - scored lower in this pairwise comparison

1. Total counts & total scores for IPknot

2. Individual counts for IPknot [ download as .csv ]