CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		McQFold
MCC	0.716	>	0.465
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077	>	0.466 ± 0.067
Sensitivity	0.652	>	0.458
Positive Predictive Value	0.787	>	0.475
Total TP	1226	>	860
Total TN	1050327	>	1050072
Total FP	467	<	1050
Total FP CONTRA	48	<	177
Total FP INCONS	283	<	775
Total FP COMP	136	>	98
Total FN	653	<	1019
P-value	5.19332990918e-08

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Performance plots

Comparison of performance of PPfold(seed) and McQFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and McQFold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and McQFold).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and McQFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and McQFold).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1226
Total TN	1050327
Total FP	467
Total FP CONTRA	48
Total FP INCONS	283
Total FP COMP	136
Total FN	653

Total Scores
MCC	0.716
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077
Sensitivity	0.652
Positive Predictive Value	0.787
Nr of predictions	23

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00805	RNAIII links to Rfam database...	0.46	0.21	1.00	32	133354	0	0	0	0	118
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

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Performance of McQFold - scored lower in this pairwise comparison

1. Total counts & total scores for McQFold

Total Base Pair Counts
Total TP	860
Total TN	1050072
Total FP	1050
Total FP CONTRA	177
Total FP INCONS	775
Total FP COMP	98
Total FN	1019

Total Scores
MCC	0.465
Average MCC ± 95% Confidence Intervals	0.466 ± 0.067
Sensitivity	0.458
Positive Predictive Value	0.475
Nr of predictions	23

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2. Individual counts for McQFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.21	0.22	0.21	19	56526	76	15	56	5	68
RFA_00627	rne5 links to Rfam database...	0.42	0.40	0.44	35	56873	47	13	32	2	52
RFA_00628	rne5 links to Rfam database...	0.42	0.41	0.43	35	57209	50	7	40	3	51
RFA_00630	rne5 links to Rfam database...	0.63	0.63	0.63	55	56865	41	6	27	8	32
RFA_00805	RNAIII links to Rfam database...	0.56	0.52	0.60	78	133256	57	3	49	5	72
RFA_00814	R2_retro_el links to Rfam database...	0.79	0.80	0.77	33	25157	21	0	10	11	8
RFA_00816	R2_retro_el links to Rfam database...	0.82	0.85	0.80	35	23176	12	4	5	3	6
RFA_00817	R2_retro_el links to Rfam database...	0.35	0.39	0.31	16	21894	39	9	26	4	25
RFA_00818	R2_retro_el links to Rfam database...	0.28	0.27	0.29	11	20263	30	12	15	3	30
RFA_00819	R2_retro_el links to Rfam database...	0.30	0.29	0.31	12	27927	50	4	23	23	29
SRP_00079	Plant_SRP links to Rfam database...	0.42	0.41	0.44	36	41823	55	1	45	9	52
SRP_00099	Plant_SRP links to Rfam database...	0.44	0.43	0.45	41	44759	50	6	44	0	54
SRP_00124	Metazoa_SRP links to Rfam database...	0.43	0.40	0.46	34	37054	43	6	34	3	51
SRP_00182	Plant_SRP links to Rfam database...	0.70	0.69	0.71	70	45957	32	7	22	3	31
SRP_00241	Plant_SRP links to Rfam database...	0.30	0.30	0.29	25	45971	62	12	48	2	57
SRP_00252	Metazoa_SRP links to Rfam database...	0.39	0.40	0.37	36	49044	62	19	42	1	53
SRP_00253	Metazoa_SRP links to Rfam database...	0.41	0.42	0.40	38	49361	62	8	48	6	52
SRP_00257	Metazoa_SRP links to Rfam database...	0.44	0.40	0.49	43	50953	45	7	37	1	65
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.52	0.61	52	47810	36	7	26	3	48
SRP_00328	Metazoa_SRP links to Rfam database...	0.49	0.49	0.49	42	39536	43	10	33	0	43
SRP_00329	Metazoa_SRP links to Rfam database...	0.38	0.38	0.40	32	39822	50	8	41	1	53
SRP_00331	Metazoa_SRP links to Rfam database...	0.50	0.47	0.53	41	37598	36	4	32	0	46
SRP_00340	Metazoa_SRP links to Rfam database...	0.48	0.50	0.46	41	41238	51	9	40	2	41

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of McQFold - scored lower in this pairwise comparison

1. Total counts & total scores for McQFold

2. Individual counts for McQFold [ download as .csv ]