CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		PknotsRG
MCC	0.716	>	0.642
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077	>	0.630 ± 0.093
Sensitivity	0.652	<	0.655
Positive Predictive Value	0.787	>	0.631
Total TP	1226	<	1230
Total TN	1050327	>	1049935
Total FP	467	<	889
Total FP CONTRA	48	<	156
Total FP INCONS	283	<	563
Total FP COMP	136	<	170
Total FN	653	>	649
P-value	5.19332990918e-08

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Performance plots

Comparison of performance of PPfold(seed) and PknotsRG. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and PknotsRG).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and PknotsRG).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and PknotsRG. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and PknotsRG).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1226
Total TN	1050327
Total FP	467
Total FP CONTRA	48
Total FP INCONS	283
Total FP COMP	136
Total FN	653

Total Scores
MCC	0.716
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077
Sensitivity	0.652
Positive Predictive Value	0.787
Nr of predictions	23

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00805	RNAIII links to Rfam database...	0.46	0.21	1.00	32	133354	0	0	0	0	118
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

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Performance of PknotsRG - scored lower in this pairwise comparison

1. Total counts & total scores for PknotsRG

Total Base Pair Counts
Total TP	1230
Total TN	1049935
Total FP	889
Total FP CONTRA	156
Total FP INCONS	563
Total FP COMP	170
Total FN	649

Total Scores
MCC	0.642
Average MCC ± 95% Confidence Intervals	0.630 ± 0.093
Sensitivity	0.655
Positive Predictive Value	0.631
Nr of predictions	23

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2. Individual counts for PknotsRG [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.89	0.86	0.93	75	56535	28	2	4	22	12
RFA_00627	rne5 links to Rfam database...	0.73	0.70	0.76	61	56873	35	4	15	16	26
RFA_00628	rne5 links to Rfam database...	0.78	0.74	0.81	64	57212	40	0	15	25	22
RFA_00630	rne5 links to Rfam database...	0.60	0.60	0.60	52	56866	44	8	27	9	35
RFA_00805	RNAIII links to Rfam database...	0.56	0.55	0.56	83	133238	77	6	59	12	67
RFA_00814	R2_retro_el links to Rfam database...	0.91	0.95	0.87	39	25155	23	4	2	17	2
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.73	0.63	30	23172	26	12	6	8	11
RFA_00817	R2_retro_el links to Rfam database...	0.10	0.12	0.08	5	21885	56	16	39	1	36
RFA_00818	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	20245	56	20	36	0	41
RFA_00819	R2_retro_el links to Rfam database...	0.79	0.80	0.79	33	27924	34	0	9	25	8
SRP_00079	Plant_SRP links to Rfam database...	0.57	0.59	0.56	52	41812	46	3	38	5	36
SRP_00099	Plant_SRP links to Rfam database...	0.58	0.59	0.57	56	44751	45	9	34	2	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.57	0.56	0.57	48	37044	38	6	30	2	37
SRP_00182	Plant_SRP links to Rfam database...	0.74	0.72	0.77	73	45961	23	5	17	1	28
SRP_00241	Plant_SRP links to Rfam database...	0.54	0.59	0.50	48	45960	50	12	36	2	34
SRP_00252	Metazoa_SRP links to Rfam database...	0.63	0.65	0.62	58	49047	39	10	26	3	31
SRP_00253	Metazoa_SRP links to Rfam database...	0.62	0.63	0.60	57	49360	43	7	31	5	33
SRP_00257	Metazoa_SRP links to Rfam database...	0.85	0.86	0.84	93	50929	20	4	14	2	15
SRP_00260	Metazoa_SRP links to Rfam database...	0.75	0.78	0.72	78	47787	32	8	22	2	22
SRP_00328	Metazoa_SRP links to Rfam database...	0.69	0.71	0.68	60	39533	31	7	21	3	25
SRP_00329	Metazoa_SRP links to Rfam database...	0.75	0.74	0.75	63	39819	24	3	18	3	22
SRP_00331	Metazoa_SRP links to Rfam database...	0.64	0.63	0.65	55	37590	33	2	28	3	32
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.57	0.52	47	41237	46	8	36	2	35

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of PknotsRG - scored lower in this pairwise comparison

1. Total counts & total scores for PknotsRG

2. Individual counts for PknotsRG [ download as .csv ]