CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		RNASLOpt
MCC	0.735	>	0.489
Average MCC ± 95% Confidence Intervals	0.762 ± 0.075	>	0.480 ± 0.086
Sensitivity	0.691	>	0.475
Positive Predictive Value	0.783	>	0.505
Total TP	1194	>	821
Total TN	916973	>	916873
Total FP	467	<	891
Total FP CONTRA	48	<	177
Total FP INCONS	283	<	627
Total FP COMP	136	>	87
Total FN	535	<	908
P-value	4.98172311752e-08

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Performance plots

Comparison of performance of PPfold(seed) and RNASLOpt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and RNASLOpt).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and RNASLOpt).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and RNASLOpt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and RNASLOpt).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1194
Total TN	916973
Total FP	467
Total FP CONTRA	48
Total FP INCONS	283
Total FP COMP	136
Total FN	535

Total Scores
MCC	0.735
Average MCC ± 95% Confidence Intervals	0.762 ± 0.075
Sensitivity	0.691
Positive Predictive Value	0.783
Nr of predictions	22

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

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Performance of RNASLOpt - scored lower in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP	821
Total TN	916873
Total FP	891
Total FP CONTRA	177
Total FP INCONS	627
Total FP COMP	87
Total FN	908

Total Scores
MCC	0.489
Average MCC ± 95% Confidence Intervals	0.480 ± 0.086
Sensitivity	0.475
Positive Predictive Value	0.505
Nr of predictions	22

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.68	0.64	0.72	56	56538	30	6	16	8	31
RFA_00627	rne5 links to Rfam database...	0.61	0.60	0.62	52	56869	41	11	21	9	35
RFA_00628	rne5 links to Rfam database...	0.89	0.84	0.95	72	57215	15	0	4	11	14
RFA_00630	rne5 links to Rfam database...	0.69	0.67	0.72	58	56872	32	5	18	9	29
RFA_00814	R2_retro_el links to Rfam database...	0.51	0.51	0.51	21	25159	29	9	11	9	20
RFA_00816	R2_retro_el links to Rfam database...	0.58	0.63	0.53	26	23171	26	13	10	3	15
RFA_00817	R2_retro_el links to Rfam database...	0.24	0.27	0.22	11	21896	42	12	26	4	30
RFA_00818	R2_retro_el links to Rfam database...	0.21	0.22	0.21	9	20258	39	14	20	5	32
RFA_00819	R2_retro_el links to Rfam database...	0.60	0.68	0.53	28	27913	34	16	9	9	13
SRP_00079	Plant_SRP links to Rfam database...	0.62	0.57	0.68	50	41832	24	3	20	1	38
SRP_00099	Plant_SRP links to Rfam database...	0.43	0.41	0.44	39	44762	49	7	42	0	56
SRP_00124	Metazoa_SRP links to Rfam database...	0.39	0.36	0.43	31	37056	41	8	33	0	54
SRP_00182	Plant_SRP links to Rfam database...	0.54	0.51	0.57	52	45965	39	11	28	0	49
SRP_00241	Plant_SRP links to Rfam database...	0.26	0.27	0.26	22	45970	66	14	50	2	60
SRP_00252	Metazoa_SRP links to Rfam database...	0.44	0.42	0.46	37	49061	48	6	37	5	52
SRP_00253	Metazoa_SRP links to Rfam database...	0.23	0.22	0.23	20	49369	69	9	57	3	70
SRP_00257	Metazoa_SRP links to Rfam database...	0.56	0.52	0.61	56	50948	37	1	35	1	52
SRP_00260	Metazoa_SRP links to Rfam database...	0.69	0.66	0.72	66	47803	28	8	18	2	34
SRP_00328	Metazoa_SRP links to Rfam database...	0.60	0.60	0.61	51	39537	36	7	26	3	34
SRP_00329	Metazoa_SRP links to Rfam database...	0.34	0.32	0.36	27	39829	50	4	43	3	58
SRP_00331	Metazoa_SRP links to Rfam database...	0.15	0.13	0.17	11	37612	52	1	51	0	76
SRP_00340	Metazoa_SRP links to Rfam database...	0.30	0.32	0.29	26	41238	64	12	52	0	56

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of RNASLOpt - scored lower in this pairwise comparison

1. Total counts & total scores for RNASLOpt

2. Individual counts for RNASLOpt [ download as .csv ]