CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		RNAalifold(seed)
MCC	0.716	>	0.698
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077	>	0.714 ± 0.066
Sensitivity	0.652	>	0.574
Positive Predictive Value	0.787	<	0.850
Total TP	1226	>	1079
Total TN	1050327	<	1050615
Total FP	467	>	286
Total FP CONTRA	48	>	27
Total FP INCONS	283	>	163
Total FP COMP	136	>	96
Total FN	653	<	800
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of PPfold(seed) and RNAalifold(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and RNAalifold(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and RNAalifold(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and RNAalifold(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and RNAalifold(seed)).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1226
Total TN	1050327
Total FP	467
Total FP CONTRA	48
Total FP INCONS	283
Total FP COMP	136
Total FN	653

Total Scores
MCC	0.716
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077
Sensitivity	0.652
Positive Predictive Value	0.787
Nr of predictions	23

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00805	RNAIII links to Rfam database...	0.46	0.21	1.00	32	133354	0	0	0	0	118
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

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Performance of RNAalifold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

Total Base Pair Counts
Total TP	1079
Total TN	1050615
Total FP	286
Total FP CONTRA	27
Total FP INCONS	163
Total FP COMP	96
Total FN	800

Total Scores
MCC	0.698
Average MCC ± 95% Confidence Intervals	0.714 ± 0.066
Sensitivity	0.574
Positive Predictive Value	0.850
Nr of predictions	23

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2. Individual counts for RNAalifold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.97	0.94	1.00	82	56534	6	0	0	6	5
RFA_00627	rne5 links to Rfam database...	0.96	0.93	1.00	81	56872	7	0	0	7	6
RFA_00628	rne5 links to Rfam database...	0.97	0.94	1.00	81	57210	6	0	0	6	5
RFA_00630	rne5 links to Rfam database...	0.92	0.87	0.96	76	56874	12	0	3	9	11
RFA_00805	RNAIII links to Rfam database...	0.50	0.37	0.69	55	133306	25	0	25	0	95
RFA_00814	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	25172	0	0	0	0	13
RFA_00816	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	23192	0	0	0	0	13
RFA_00817	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	21917	0	0	0	0	13
RFA_00818	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	20273	0	0	0	0	13
RFA_00819	R2_retro_el links to Rfam database...	0.83	0.68	1.00	28	27938	0	0	0	0	13
SRP_00079	Plant_SRP links to Rfam database...	0.63	0.50	0.80	44	41850	15	0	11	4	44
SRP_00099	Plant_SRP links to Rfam database...	0.68	0.51	0.92	48	44798	8	0	4	4	47
SRP_00124	Metazoa_SRP links to Rfam database...	0.63	0.46	0.87	39	37083	15	2	4	9	46
SRP_00182	Plant_SRP links to Rfam database...	0.73	0.55	0.95	56	45997	4	0	3	1	45
SRP_00241	Plant_SRP links to Rfam database...	0.59	0.48	0.72	39	46002	22	4	11	7	43
SRP_00252	Metazoa_SRP links to Rfam database...	0.56	0.49	0.64	44	49072	32	5	20	7	45
SRP_00253	Metazoa_SRP links to Rfam database...	0.57	0.49	0.68	44	49390	27	4	17	6	46
SRP_00257	Metazoa_SRP links to Rfam database...	0.55	0.40	0.77	43	50984	14	4	9	1	65
SRP_00260	Metazoa_SRP links to Rfam database...	0.54	0.44	0.66	44	47828	27	4	19	4	56
SRP_00328	Metazoa_SRP links to Rfam database...	0.64	0.48	0.85	41	39573	11	1	6	4	44
SRP_00329	Metazoa_SRP links to Rfam database...	0.66	0.51	0.86	43	39853	14	0	7	7	42
SRP_00331	Metazoa_SRP links to Rfam database...	0.58	0.47	0.72	41	37618	21	1	15	5	46
SRP_00340	Metazoa_SRP links to Rfam database...	0.60	0.46	0.78	38	41279	20	2	9	9	44

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of RNAalifold(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RNAalifold(seed)

2. Individual counts for RNAalifold(seed) [ download as .csv ]