CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		RNAshapes
MCC	0.726	>	0.593
Average MCC ± 95% Confidence Intervals	0.755 ± 0.078	>	0.578 ± 0.084
Sensitivity	0.682	>	0.602
Positive Predictive Value	0.773	>	0.586
Total TP	1120	>	988
Total TN	860096	>	859859
Total FP	462	<	842
Total FP CONTRA	48	<	145
Total FP INCONS	281	<	553
Total FP COMP	133	<	144
Total FN	522	<	654
P-value	5.10776592382e-08

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Performance plots

Comparison of performance of PPfold(seed) and RNAshapes. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and RNAshapes).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and RNAshapes).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and RNAshapes. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and RNAshapes).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1120
Total TN	860096
Total FP	462
Total FP CONTRA	48
Total FP INCONS	281
Total FP COMP	133
Total FN	522

Total Scores
MCC	0.726
Average MCC ± 95% Confidence Intervals	0.755 ± 0.078
Sensitivity	0.682
Positive Predictive Value	0.773
Nr of predictions	21

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

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Performance of RNAshapes - scored lower in this pairwise comparison

1. Total counts & total scores for RNAshapes

Total Base Pair Counts
Total TP	988
Total TN	859859
Total FP	842
Total FP CONTRA	145
Total FP INCONS	553
Total FP COMP	144
Total FN	654

Total Scores
MCC	0.593
Average MCC ± 95% Confidence Intervals	0.578 ± 0.084
Sensitivity	0.602
Positive Predictive Value	0.586
Nr of predictions	21

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2. Individual counts for RNAshapes [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.45	0.45	0.46	39	56531	61	9	37	15	48
RFA_00627	rne5 links to Rfam database...	0.63	0.61	0.66	53	56873	42	4	23	15	34
RFA_00628	rne5 links to Rfam database...	0.82	0.80	0.84	69	57209	33	1	12	20	17
RFA_00814	R2_retro_el links to Rfam database...	0.62	0.63	0.60	26	25157	26	6	11	9	15
RFA_00816	R2_retro_el links to Rfam database...	0.21	0.24	0.18	10	23164	47	18	28	1	31
RFA_00817	R2_retro_el links to Rfam database...	0.10	0.12	0.08	5	21881	60	21	38	1	36
RFA_00818	R2_retro_el links to Rfam database...	0.52	0.56	0.48	23	20253	31	9	16	6	18
RFA_00819	R2_retro_el links to Rfam database...	0.84	0.80	0.87	33	27928	36	0	5	31	8
SRP_00079	Plant_SRP links to Rfam database...	0.53	0.52	0.53	46	41819	52	1	39	12	42
SRP_00099	Plant_SRP links to Rfam database...	0.54	0.55	0.54	52	44754	45	5	39	1	43
SRP_00124	Metazoa_SRP links to Rfam database...	0.42	0.41	0.42	35	37045	51	5	43	3	50
SRP_00182	Plant_SRP links to Rfam database...	0.59	0.56	0.61	57	45963	37	5	31	1	44
SRP_00241	Plant_SRP links to Rfam database...	0.55	0.59	0.52	48	45963	47	13	32	2	34
SRP_00252	Metazoa_SRP links to Rfam database...	0.62	0.63	0.62	56	49050	38	9	26	3	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.62	0.64	0.60	58	49358	45	9	30	6	32
SRP_00257	Metazoa_SRP links to Rfam database...	0.86	0.83	0.88	90	50938	17	1	11	5	18
SRP_00260	Metazoa_SRP links to Rfam database...	0.75	0.77	0.73	77	47789	31	6	23	2	23
SRP_00328	Metazoa_SRP links to Rfam database...	0.64	0.65	0.63	55	39533	38	8	25	5	30
SRP_00329	Metazoa_SRP links to Rfam database...	0.67	0.66	0.67	56	39820	28	4	23	1	29
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.61	0.66	53	37595	30	2	25	3	34
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.57	0.51	47	41236	47	9	36	2	35

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of RNAshapes - scored lower in this pairwise comparison

1. Total counts & total scores for RNAshapes

2. Individual counts for RNAshapes [ download as .csv ]