CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

Home

Methods

Datasets

Rankings

RNA 2D Atlas

Help

FAQ

Contact us

RSS feeds

Twitter

Overview

Metric	PPfold(seed)		RNAsubopt
MCC	0.735	>	0.641
Average MCC ± 95% Confidence Intervals	0.762 ± 0.075	>	0.635 ± 0.064
Sensitivity	0.691	>	0.658
Positive Predictive Value	0.783	>	0.626
Total TP	1194	>	1137
Total TN	916973	>	916682
Total FP	467	<	857
Total FP CONTRA	48	<	149
Total FP INCONS	283	<	530
Total FP COMP	136	<	178
Total FN	535	<	592
P-value	3.56938820447e-08

^top

Performance plots

Comparison of performance of PPfold(seed) and RNAsubopt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and RNAsubopt).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and RNAsubopt).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and RNAsubopt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and RNAsubopt).

^top

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1194
Total TN	916973
Total FP	467
Total FP CONTRA	48
Total FP INCONS	283
Total FP COMP	136
Total FN	535

Total Scores
MCC	0.735
Average MCC ± 95% Confidence Intervals	0.762 ± 0.075
Sensitivity	0.691
Positive Predictive Value	0.783
Nr of predictions	22

^top

2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

^top

Performance of RNAsubopt - scored lower in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP	1137
Total TN	916682
Total FP	857
Total FP CONTRA	149
Total FP INCONS	530
Total FP COMP	178
Total FN	592

Total Scores
MCC	0.641
Average MCC ± 95% Confidence Intervals	0.635 ± 0.064
Sensitivity	0.658
Positive Predictive Value	0.626
Nr of predictions	22

^top

2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.68	0.66	0.70	57	56535	42	6	18	18	30
RFA_00627	rne5 links to Rfam database...	0.72	0.68	0.77	59	56876	33	4	14	15	28
RFA_00628	rne5 links to Rfam database...	0.89	0.86	0.91	74	57210	32	2	5	25	12
RFA_00630	rne5 links to Rfam database...	0.58	0.60	0.57	52	56861	51	12	28	11	35
RFA_00814	R2_retro_el links to Rfam database...	0.39	0.39	0.39	16	25159	40	5	20	15	25
RFA_00816	R2_retro_el links to Rfam database...	0.74	0.78	0.70	32	23174	24	8	6	10	9
RFA_00817	R2_retro_el links to Rfam database...	0.35	0.41	0.30	17	21889	43	11	28	4	24
RFA_00818	R2_retro_el links to Rfam database...	0.47	0.54	0.41	22	20247	39	13	19	7	19
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	31	0	1	30	2
SRP_00079	Plant_SRP links to Rfam database...	0.71	0.73	0.70	64	41813	35	4	24	7	24
SRP_00099	Plant_SRP links to Rfam database...	0.61	0.63	0.60	60	44750	42	7	33	2	35
SRP_00124	Metazoa_SRP links to Rfam database...	0.67	0.67	0.68	57	37044	30	4	23	3	28
SRP_00182	Plant_SRP links to Rfam database...	0.70	0.68	0.71	69	45959	31	2	26	3	32
SRP_00241	Plant_SRP links to Rfam database...	0.55	0.59	0.52	48	45963	48	12	33	3	34
SRP_00252	Metazoa_SRP links to Rfam database...	0.53	0.56	0.50	50	49041	53	13	37	3	39
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.67	0.61	60	49357	43	6	32	5	30
SRP_00257	Metazoa_SRP links to Rfam database...	0.80	0.81	0.79	87	50930	26	4	19	3	21
SRP_00260	Metazoa_SRP links to Rfam database...	0.64	0.69	0.60	69	47780	48	7	39	2	31
SRP_00328	Metazoa_SRP links to Rfam database...	0.64	0.66	0.63	56	39532	38	8	25	5	29
SRP_00329	Metazoa_SRP links to Rfam database...	0.61	0.62	0.60	53	39814	37	10	26	1	32
SRP_00331	Metazoa_SRP links to Rfam database...	0.55	0.55	0.55	48	37587	43	3	37	3	39
SRP_00340	Metazoa_SRP links to Rfam database...	0.55	0.59	0.52	48	41235	48	8	37	3	34

^top

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of RNAsubopt - scored lower in this pairwise comparison

1. Total counts & total scores for RNAsubopt

2. Individual counts for RNAsubopt [ download as .csv ]