CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		RNAwolf
MCC	0.716	>	0.389
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077	>	0.362 ± 0.085
Sensitivity	0.652	>	0.408
Positive Predictive Value	0.787	>	0.373
Total TP	1226	>	767
Total TN	1050327	>	1049827
Total FP	467	<	1582
Total FP CONTRA	48	<	247
Total FP INCONS	283	<	1043
Total FP COMP	136	<	292
Total FN	653	<	1112
P-value	5.06544643719e-08

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Performance plots

Comparison of performance of PPfold(seed) and RNAwolf. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and RNAwolf).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and RNAwolf).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and RNAwolf. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and RNAwolf).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1226
Total TN	1050327
Total FP	467
Total FP CONTRA	48
Total FP INCONS	283
Total FP COMP	136
Total FN	653

Total Scores
MCC	0.716
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077
Sensitivity	0.652
Positive Predictive Value	0.787
Nr of predictions	23

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00805	RNAIII links to Rfam database...	0.46	0.21	1.00	32	133354	0	0	0	0	118
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

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Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

Total Base Pair Counts
Total TP	767
Total TN	1049827
Total FP	1582
Total FP CONTRA	247
Total FP INCONS	1043
Total FP COMP	292
Total FN	1112

Total Scores
MCC	0.389
Average MCC ± 95% Confidence Intervals	0.362 ± 0.085
Sensitivity	0.408
Positive Predictive Value	0.373
Nr of predictions	23

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2. Individual counts for RNAwolf [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.08	0.09	0.08	8	56511	99	24	73	2	79
RFA_00627	rne5 links to Rfam database...	0.38	0.39	0.37	34	56862	73	13	44	16	53
RFA_00628	rne5 links to Rfam database...	0.58	0.57	0.59	49	57208	64	7	27	30	37
RFA_00630	rne5 links to Rfam database...	0.48	0.47	0.49	41	56869	66	9	34	23	46
RFA_00805	RNAIII links to Rfam database...	0.30	0.31	0.29	47	133225	121	13	101	7	103
RFA_00814	R2_retro_el links to Rfam database...	0.20	0.22	0.18	9	25149	62	12	30	20	32
RFA_00816	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	23162	66	17	41	8	41
RFA_00817	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	21892	57	12	41	4	41
RFA_00818	R2_retro_el links to Rfam database...	0.25	0.27	0.23	11	20253	51	12	25	14	30
RFA_00819	R2_retro_el links to Rfam database...	0.16	0.17	0.16	7	27921	70	6	32	32	34
SRP_00079	Plant_SRP links to Rfam database...	0.53	0.55	0.51	48	41811	63	9	37	17	40
SRP_00099	Plant_SRP links to Rfam database...	0.55	0.57	0.53	54	44749	60	9	38	13	41
SRP_00124	Metazoa_SRP links to Rfam database...	0.54	0.56	0.53	48	37037	55	8	35	12	37
SRP_00182	Plant_SRP links to Rfam database...	0.34	0.35	0.34	35	45952	72	13	56	3	66
SRP_00241	Plant_SRP links to Rfam database...	0.55	0.60	0.51	49	45959	61	14	34	13	33
SRP_00252	Metazoa_SRP links to Rfam database...	0.32	0.35	0.30	31	49039	79	12	59	8	58
SRP_00253	Metazoa_SRP links to Rfam database...	0.22	0.24	0.20	22	49346	89	14	73	2	68
SRP_00257	Metazoa_SRP links to Rfam database...	0.68	0.69	0.67	75	50928	49	5	32	12	33
SRP_00260	Metazoa_SRP links to Rfam database...	0.58	0.60	0.57	60	47790	58	8	37	13	40
SRP_00328	Metazoa_SRP links to Rfam database...	0.32	0.33	0.31	28	39530	68	12	51	5	57
SRP_00329	Metazoa_SRP links to Rfam database...	0.31	0.33	0.30	28	39810	75	5	60	10	57
SRP_00331	Metazoa_SRP links to Rfam database...	0.61	0.61	0.61	53	37588	49	3	31	15	34
SRP_00340	Metazoa_SRP links to Rfam database...	0.34	0.37	0.33	30	41236	75	10	52	13	52

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of RNAwolf - scored lower in this pairwise comparison

1. Total counts & total scores for RNAwolf

2. Individual counts for RNAwolf [ download as .csv ]