CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PPfold(seed)		RSpredict(seed)
MCC	0.716	>	0.007
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077	>	0.004 ± 0.009
Sensitivity	0.652	>	0.008
Positive Predictive Value	0.787	>	0.010
Total TP	1226	>	15
Total TN	1050327	<	1050401
Total FP	467	<	1505
Total FP CONTRA	48	<	228
Total FP INCONS	283	<	1240
Total FP COMP	136	>	37
Total FN	653	<	1864
P-value	5.23657817852e-08

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Performance plots

Comparison of performance of PPfold(seed) and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PPfold(seed) and RSpredict(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PPfold(seed) and RSpredict(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for PPfold(seed) and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PPfold(seed) and RSpredict(seed)).

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Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

Total Base Pair Counts
Total TP	1226
Total TN	1050327
Total FP	467
Total FP CONTRA	48
Total FP INCONS	283
Total FP COMP	136
Total FN	653

Total Scores
MCC	0.716
Average MCC ± 95% Confidence Intervals	0.749 ± 0.077
Sensitivity	0.652
Positive Predictive Value	0.787
Nr of predictions	23

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2. Individual counts for PPfold(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.94	0.89	1.00	77	56539	1	0	0	1	10
RFA_00627	rne5 links to Rfam database...	0.95	0.91	1.00	79	56874	4	0	0	4	8
RFA_00628	rne5 links to Rfam database...	0.95	0.91	1.00	78	57213	2	0	0	2	8
RFA_00630	rne5 links to Rfam database...	0.91	0.85	0.97	74	56877	5	0	2	3	13
RFA_00805	RNAIII links to Rfam database...	0.46	0.21	1.00	32	133354	0	0	0	0	118
RFA_00814	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	25164	2	0	0	2	5
RFA_00816	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	23183	2	0	0	2	4
RFA_00817	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	21908	1	0	0	1	4
RFA_00818	R2_retro_el links to Rfam database...	0.94	0.88	1.00	36	20265	2	0	0	2	5
RFA_00819	R2_retro_el links to Rfam database...	0.95	0.90	1.00	37	27929	2	0	0	2	4
SRP_00079	Plant_SRP links to Rfam database...	0.74	0.69	0.79	61	41828	28	0	16	12	27
SRP_00099	Plant_SRP links to Rfam database...	0.60	0.59	0.62	56	44760	40	2	32	6	39
SRP_00124	Metazoa_SRP links to Rfam database...	0.71	0.66	0.76	56	37054	27	3	15	9	29
SRP_00182	Plant_SRP links to Rfam database...	0.85	0.78	0.92	79	45970	17	0	7	10	22
SRP_00241	Plant_SRP links to Rfam database...	0.53	0.52	0.54	43	45977	49	9	27	13	39
SRP_00252	Metazoa_SRP links to Rfam database...	0.64	0.63	0.64	56	49054	42	5	26	11	33
SRP_00253	Metazoa_SRP links to Rfam database...	0.64	0.62	0.66	56	49370	40	5	24	11	34
SRP_00257	Metazoa_SRP links to Rfam database...	0.51	0.44	0.59	48	50959	36	5	28	3	60
SRP_00260	Metazoa_SRP links to Rfam database...	0.56	0.51	0.61	51	47811	39	5	28	6	49
SRP_00328	Metazoa_SRP links to Rfam database...	0.61	0.56	0.67	48	39549	29	5	19	5	37
SRP_00329	Metazoa_SRP links to Rfam database...	0.72	0.67	0.78	57	39830	26	2	14	10	28
SRP_00331	Metazoa_SRP links to Rfam database...	0.63	0.59	0.69	51	37601	31	2	21	8	36
SRP_00340	Metazoa_SRP links to Rfam database...	0.54	0.50	0.59	41	41258	42	5	24	13	41

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP	15
Total TN	1050401
Total FP	1505
Total FP CONTRA	228
Total FP INCONS	1240
Total FP COMP	37
Total FN	1864

Total Scores
MCC	0.007
Average MCC ± 95% Confidence Intervals	0.004 ± 0.009
Sensitivity	0.008
Positive Predictive Value	0.010
Nr of predictions	23

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00626	rne5 links to Rfam database...	0.00	0.00	0.00	0	56534	83	16	66	1	87
RFA_00627	rne5 links to Rfam database...	0.00	0.00	0.00	0	56869	84	21	63	0	87
RFA_00628	rne5 links to Rfam database...	0.00	0.00	0.00	0	57206	85	25	60	0	86
RFA_00630	rne5 links to Rfam database...	0.07	0.07	0.07	6	56872	79	18	57	4	81
RFA_00805	RNAIII links to Rfam database...	0.07	0.06	0.08	9	133271	106	9	97	0	141
RFA_00814	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	25168	36	2	30	4	41
RFA_00816	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	23193	37	5	22	10	41
RFA_00817	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	21919	34	5	21	8	41
RFA_00818	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	20276	28	2	23	3	41
RFA_00819	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	27928	44	7	31	6	41
SRP_00079	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	41841	65	9	55	1	88
SRP_00099	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	44782	68	9	59	0	95
SRP_00124	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	37067	61	6	55	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	45987	69	10	59	0	101
SRP_00241	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	45983	73	13	60	0	82
SRP_00252	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	49071	70	13	57	0	89
SRP_00253	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	49388	67	11	56	0	90
SRP_00257	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	50958	82	6	76	0	108
SRP_00260	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	47824	71	3	68	0	100
SRP_00328	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	39557	64	8	56	0	85
SRP_00329	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	39842	61	8	53	0	85
SRP_00331	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	37606	69	9	60	0	87
SRP_00340	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	41259	69	13	56	0	82

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PPfold(seed) - scored higher in this pairwise comparison

1. Total counts & total scores for PPfold(seed)

2. Individual counts for PPfold(seed) [ download as .csv ]

Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

2. Individual counts for RSpredict(seed) [ download as .csv ]