CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	PknotsRG		CMfinder(seed)
MCC	0.606	>	0.454
Average MCC ± 95% Confidence Intervals	0.595 ± 0.067	>	0.456 ± 0.042
Sensitivity	0.611	>	0.271
Positive Predictive Value	0.602	<	0.762
Total TP	2814	>	1249
Total TN	2620018	<	2623051
Total FP	2240	>	419
Total FP CONTRA	362	>	30
Total FP INCONS	1496	>	360
Total FP COMP	382	>	29
Total FN	1789	<	3354
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of PknotsRG and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for PknotsRG and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for PknotsRG and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for PknotsRG and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for PknotsRG and CMfinder(seed)).

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Performance of PknotsRG - scored higher in this pairwise comparison

1. Total counts & total scores for PknotsRG

Total Base Pair Counts
Total TP	2814
Total TN	2620018
Total FP	2240
Total FP CONTRA	362
Total FP INCONS	1496
Total FP COMP	382
Total FN	1789

Total Scores
MCC	0.606
Average MCC ± 95% Confidence Intervals	0.595 ± 0.067
Sensitivity	0.611
Positive Predictive Value	0.602
Nr of predictions	51

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2. Individual counts for PknotsRG [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.16	0.17	0.15	19	103617	114	25	79	10	96
CRW_00016	Intron_gpI links to Rfam database...	0.64	0.62	0.66	74	77309	50	5	33	12	46
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.49	0.49	40	36233	43	7	35	1	41
CRW_00613	Intron_gpI links to Rfam database...	0.64	0.59	0.69	46	34913	29	1	20	8	32
CRW_00614	Intron_gpI links to Rfam database...	0.09	0.11	0.07	6	121690	145	21	54	70	51
CRW_00618	Intron_gpI links to Rfam database...	0.11	0.11	0.10	7	56211	83	13	49	21	54
CRW_00633	Intron_gpI links to Rfam database...	0.50	0.48	0.52	51	63447	50	10	38	2	55
CRW_00634	Intron_gpI links to Rfam database...	0.56	0.60	0.52	56	64513	53	17	34	2	38
CRW_00670	Intron_gpI links to Rfam database...	0.75	0.74	0.77	89	70009	30	5	22	3	31
CRW_00671	Intron_gpI links to Rfam database...	0.77	0.76	0.78	89	62721	30	6	19	5	28
CRW_00672	Intron_gpI links to Rfam database...	0.53	0.55	0.52	61	72273	60	21	35	4	50
CRW_00674	Intron_gpI links to Rfam database...	0.52	0.52	0.52	65	83310	63	12	49	2	59
CRW_00676	Intron_gpI links to Rfam database...	0.56	0.60	0.52	69	93396	67	13	50	4	46
CRW_00692	Intron_gpI links to Rfam database...	0.43	0.46	0.41	41	68536	66	18	40	8	49
PDB_00827	Intron_gpI links to Rfam database...	0.50	0.46	0.55	37	26961	31	1	29	1	44
RFA_00606	Telomerase-cil links to Rfam database...	0.66	0.67	0.65	26	21281	28	6	8	14	13
RFA_00620	Telomerase-cil links to Rfam database...	0.63	0.62	0.65	24	21908	26	4	9	13	15
RFA_00626	rne5 links to Rfam database...	0.89	0.86	0.93	75	56535	28	2	4	22	12
RFA_00627	rne5 links to Rfam database...	0.73	0.70	0.76	61	56873	35	4	15	16	26
RFA_00628	rne5 links to Rfam database...	0.78	0.74	0.81	64	57212	40	0	15	25	22
RFA_00630	rne5 links to Rfam database...	0.60	0.60	0.60	52	56866	44	8	27	9	35
RFA_00639	7SK links to Rfam database...	0.23	0.24	0.21	21	54517	81	16	61	4	66
RFA_00814	R2_retro_el links to Rfam database...	0.91	0.95	0.87	39	25155	23	4	2	17	2
RFA_00815	R2_retro_el links to Rfam database...	0.66	0.71	0.62	29	24484	33	5	13	15	12
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.73	0.63	30	23172	26	12	6	8	11
RFA_00817	R2_retro_el links to Rfam database...	0.10	0.12	0.08	5	21885	56	16	39	1	36
RFA_00818	R2_retro_el links to Rfam database...	0.00	0.00	0.00	0	20245	56	20	36	0	41
RFA_00819	R2_retro_el links to Rfam database...	0.79	0.80	0.79	33	27924	34	0	9	25	8
SRP_00016	Archaea_SRP links to Rfam database...	0.85	0.83	0.88	91	47791	15	2	11	2	18
SRP_00130	Archaea_SRP links to Rfam database...	0.23	0.23	0.24	22	49677	71	10	61	0	75
SRP_00142	Archaea_SRP links to Rfam database...	0.67	0.67	0.67	62	45963	35	2	29	4	31
SRP_00143	Archaea_SRP links to Rfam database...	0.85	0.84	0.86	85	49671	19	1	13	5	16
SRP_00144	Archaea_SRP links to Rfam database...	0.74	0.73	0.74	69	46572	31	1	23	7	25
SRP_00197	Archaea_SRP links to Rfam database...	0.38	0.38	0.39	38	49357	61	4	56	1	63
SRP_00198	Archaea_SRP links to Rfam database...	0.38	0.38	0.38	39	50937	65	4	60	1	64
SRP_00199	Archaea_SRP links to Rfam database...	0.31	0.30	0.34	31	50948	64	4	57	3	74
SRP_00201	Archaea_SRP links to Rfam database...	0.77	0.77	0.78	85	47786	26	5	19	2	26
SRP_00202	Archaea_SRP links to Rfam database...	0.84	0.84	0.84	98	54169	22	2	16	4	19
SRP_00203	Archaea_SRP links to Rfam database...	0.74	0.75	0.72	79	48719	36	3	27	6	26
SRP_00204	Archaea_SRP links to Rfam database...	0.78	0.77	0.78	79	49040	24	4	18	2	23
SRP_00206	Archaea_SRP links to Rfam database...	0.84	0.83	0.84	90	47788	18	5	12	1	18
SRP_00208	Archaea_SRP links to Rfam database...	0.67	0.67	0.67	68	46564	35	7	26	2	33
SRP_00255	Archaea_SRP links to Rfam database...	0.60	0.62	0.59	58	47487	47	3	38	6	36
SRP_00276	Archaea_SRP links to Rfam database...	0.86	0.85	0.86	94	50612	16	5	10	1	16
SRP_00278	Archaea_SRP links to Rfam database...	0.72	0.72	0.72	76	45951	31	4	25	2	29
SRP_00321	Archaea_SRP links to Rfam database...	0.78	0.77	0.79	83	47481	24	3	19	2	25
SRP_00322	Archaea_SRP links to Rfam database...	0.61	0.61	0.60	67	48405	45	6	38	1	42
SRP_00323	Archaea_SRP links to Rfam database...	0.92	0.92	0.93	98	47173	10	0	7	3	9
SRP_00330	Archaea_SRP links to Rfam database...	0.49	0.49	0.48	47	49988	53	3	48	2	48
SRP_00332	Archaea_SRP links to Rfam database...	0.85	0.86	0.84	91	50295	18	6	11	1	15
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.59	0.53	55	44448	50	6	42	2	39

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of PknotsRG - scored higher in this pairwise comparison

1. Total counts & total scores for PknotsRG

2. Individual counts for PknotsRG [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]