CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	ProbKnot		CMfinder(seed)
MCC	0.600	>	0.454
Average MCC ± 95% Confidence Intervals	0.588 ± 0.060	>	0.456 ± 0.042
Sensitivity	0.599	>	0.271
Positive Predictive Value	0.602	<	0.762
Total TP	2757	>	1249
Total TN	2620111	<	2623051
Total FP	2274	>	419
Total FP CONTRA	341	>	30
Total FP INCONS	1481	>	360
Total FP COMP	452	>	29
Total FN	1846	<	3354
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of ProbKnot and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for ProbKnot and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for ProbKnot and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for ProbKnot and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for ProbKnot and CMfinder(seed)).

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Performance of ProbKnot - scored higher in this pairwise comparison

1. Total counts & total scores for ProbKnot

Total Base Pair Counts
Total TP	2757
Total TN	2620111
Total FP	2274
Total FP CONTRA	341
Total FP INCONS	1481
Total FP COMP	452
Total FN	1846

Total Scores
MCC	0.600
Average MCC ± 95% Confidence Intervals	0.588 ± 0.060
Sensitivity	0.599
Positive Predictive Value	0.602
Nr of predictions	51

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2. Individual counts for ProbKnot [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.39	0.37	0.42	43	103637	84	9	51	24	72
CRW_00016	Intron_gpI links to Rfam database...	0.48	0.45	0.50	54	77314	68	6	47	15	66
CRW_00610	Intron_gpI links to Rfam database...	0.44	0.44	0.43	36	36232	49	8	39	2	45
CRW_00613	Intron_gpI links to Rfam database...	0.84	0.82	0.86	64	34906	18	0	10	8	14
CRW_00614	Intron_gpI links to Rfam database...	0.14	0.16	0.12	9	121698	120	17	47	56	48
CRW_00618	Intron_gpI links to Rfam database...	0.18	0.20	0.16	12	56207	83	15	46	22	49
CRW_00633	Intron_gpI links to Rfam database...	0.62	0.59	0.65	63	63449	38	9	25	4	43
CRW_00634	Intron_gpI links to Rfam database...	0.50	0.49	0.52	46	64531	48	10	33	5	48
CRW_00670	Intron_gpI links to Rfam database...	0.57	0.58	0.56	70	70001	57	11	43	3	50
CRW_00671	Intron_gpI links to Rfam database...	0.79	0.77	0.80	90	62723	28	6	16	6	27
CRW_00672	Intron_gpI links to Rfam database...	0.76	0.78	0.74	87	72272	41	10	21	10	24
CRW_00674	Intron_gpI links to Rfam database...	0.68	0.67	0.70	83	83317	41	8	28	5	41
CRW_00676	Intron_gpI links to Rfam database...	0.59	0.58	0.60	67	93416	63	8	37	18	48
CRW_00692	Intron_gpI links to Rfam database...	0.33	0.34	0.32	31	68537	84	18	49	17	59
PDB_00827	Intron_gpI links to Rfam database...	0.76	0.67	0.86	54	26965	11	1	8	2	27
RFA_00606	Telomerase-cil links to Rfam database...	0.60	0.62	0.59	24	21280	33	7	10	16	15
RFA_00620	Telomerase-cil links to Rfam database...	0.43	0.49	0.38	19	21895	44	8	23	13	20
RFA_00626	rne5 links to Rfam database...	0.86	0.80	0.91	70	56539	32	1	6	25	17
RFA_00627	rne5 links to Rfam database...	0.69	0.69	0.68	60	56865	47	6	22	19	27
RFA_00628	rne5 links to Rfam database...	0.90	0.88	0.93	76	57209	31	1	5	25	10
RFA_00630	rne5 links to Rfam database...	0.69	0.66	0.72	57	56874	41	4	18	19	30
RFA_00639	7SK links to Rfam database...	0.57	0.57	0.57	50	54528	49	8	29	12	37
RFA_00814	R2_retro_el links to Rfam database...	0.32	0.37	0.28	15	25146	45	8	31	6	26
RFA_00815	R2_retro_el links to Rfam database...	0.57	0.61	0.54	25	24485	35	5	16	14	16
RFA_00816	R2_retro_el links to Rfam database...	0.80	0.88	0.73	36	23171	20	9	4	7	5
RFA_00817	R2_retro_el links to Rfam database...	0.10	0.12	0.08	5	21883	57	18	39	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.48	0.54	0.43	22	20250	38	13	16	9	19
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	34	0	1	33	2
SRP_00016	Archaea_SRP links to Rfam database...	0.79	0.78	0.80	85	47789	22	5	16	1	24
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.51	0.49	49	49670	54	9	42	3	48
SRP_00142	Archaea_SRP links to Rfam database...	0.33	0.32	0.34	30	45967	61	8	51	2	63
SRP_00143	Archaea_SRP links to Rfam database...	0.37	0.38	0.36	38	49664	70	7	61	2	63
SRP_00144	Archaea_SRP links to Rfam database...	0.38	0.39	0.38	37	46567	65	9	52	4	57
SRP_00197	Archaea_SRP links to Rfam database...	0.22	0.21	0.24	21	49368	66	5	61	0	80
SRP_00198	Archaea_SRP links to Rfam database...	0.25	0.24	0.26	25	50945	71	5	65	1	78
SRP_00199	Archaea_SRP links to Rfam database...	0.63	0.63	0.63	66	50936	41	3	35	3	39
SRP_00201	Archaea_SRP links to Rfam database...	0.71	0.70	0.72	78	47786	33	3	28	2	33
SRP_00202	Archaea_SRP links to Rfam database...	0.88	0.87	0.89	102	54170	16	2	11	3	15
SRP_00203	Archaea_SRP links to Rfam database...	0.72	0.74	0.70	78	48717	41	2	31	8	27
SRP_00204	Archaea_SRP links to Rfam database...	0.67	0.67	0.67	68	49040	33	7	26	0	34
SRP_00206	Archaea_SRP links to Rfam database...	0.86	0.88	0.83	95	47781	21	5	14	2	13
SRP_00208	Archaea_SRP links to Rfam database...	0.65	0.64	0.65	65	46565	37	9	26	2	36
SRP_00255	Archaea_SRP links to Rfam database...	0.62	0.62	0.62	58	47492	41	3	33	5	36
SRP_00276	Archaea_SRP links to Rfam database...	0.85	0.84	0.87	92	50615	17	5	9	3	18
SRP_00278	Archaea_SRP links to Rfam database...	0.67	0.67	0.67	70	45951	38	3	32	3	35
SRP_00321	Archaea_SRP links to Rfam database...	0.58	0.58	0.58	63	47477	48	11	35	2	45
SRP_00322	Archaea_SRP links to Rfam database...	0.66	0.64	0.68	70	48413	34	2	31	1	39
SRP_00323	Archaea_SRP links to Rfam database...	0.82	0.80	0.83	86	47175	20	0	17	3	21
SRP_00330	Archaea_SRP links to Rfam database...	0.42	0.39	0.46	37	50006	44	3	40	1	58
SRP_00332	Archaea_SRP links to Rfam database...	0.69	0.70	0.69	74	50296	35	7	26	2	32
SRP_00339	Archaea_SRP links to Rfam database...	0.70	0.67	0.73	63	44465	27	4	19	4	31

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1249
Total TN	2623051
Total FP	419
Total FP CONTRA	30
Total FP INCONS	360
Total FP COMP	29
Total FN	3354

Total Scores
MCC	0.454
Average MCC ± 95% Confidence Intervals	0.456 ± 0.042
Sensitivity	0.271
Positive Predictive Value	0.762
Nr of predictions	51

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00013	Intron_gpI links to Rfam database...	0.37	0.14	1.00	16	103724	0	0	0	0	99
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00614	Intron_gpI links to Rfam database...	0.46	0.25	0.88	14	121755	9	0	2	7	43
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00674	Intron_gpI links to Rfam database...	0.40	0.17	0.95	21	83414	1	0	1	0	103
CRW_00676	Intron_gpI links to Rfam database...	0.12	0.04	0.33	5	93513	10	1	9	0	110
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of ProbKnot - scored higher in this pairwise comparison

1. Total counts & total scores for ProbKnot

2. Individual counts for ProbKnot [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]