CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASLOpt		CMfinder(seed)
MCC	0.485	>	0.464
Average MCC ± 95% Confidence Intervals	0.476 ± 0.063	>	0.466 ± 0.043
Sensitivity	0.465	>	0.285
Positive Predictive Value	0.507	<	0.760
Total TP	1950	>	1193
Total TN	2218369	<	2220645
Total FP	2074	>	399
Total FP CONTRA	315	>	29
Total FP INCONS	1581	>	348
Total FP COMP	178	>	22
Total FN	2242	<	2999
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASLOpt and CMfinder(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASLOpt and CMfinder(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASLOpt and CMfinder(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASLOpt and CMfinder(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASLOpt and CMfinder(seed)).

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Performance of RNASLOpt - scored higher in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP	1950
Total TN	2218369
Total FP	2074
Total FP CONTRA	315
Total FP INCONS	1581
Total FP COMP	178
Total FN	2242

Total Scores
MCC	0.485
Average MCC ± 95% Confidence Intervals	0.476 ± 0.063
Sensitivity	0.465
Positive Predictive Value	0.507
Nr of predictions	47

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.48	0.45	0.52	54	77317	58	5	45	8	66
CRW_00610	Intron_gpI links to Rfam database...	0.06	0.06	0.07	5	36246	64	9	55	0	76
CRW_00613	Intron_gpI links to Rfam database...	0.59	0.50	0.70	39	34924	24	1	16	7	39
CRW_00618	Intron_gpI links to Rfam database...	0.21	0.21	0.21	13	56218	62	6	43	13	48
CRW_00633	Intron_gpI links to Rfam database...	0.50	0.49	0.51	52	63444	52	5	45	2	54
CRW_00634	Intron_gpI links to Rfam database...	0.50	0.50	0.51	47	64527	48	11	35	2	47
CRW_00670	Intron_gpI links to Rfam database...	0.45	0.43	0.47	52	70015	58	8	50	0	68
CRW_00671	Intron_gpI links to Rfam database...	0.60	0.53	0.68	62	62744	32	2	27	3	55
CRW_00672	Intron_gpI links to Rfam database...	0.43	0.41	0.45	45	72291	57	6	48	3	66
CRW_00692	Intron_gpI links to Rfam database...	0.33	0.34	0.33	31	68540	77	20	44	13	59
PDB_00827	Intron_gpI links to Rfam database...	0.74	0.60	0.91	49	26974	7	0	5	2	32
RFA_00606	Telomerase-cil links to Rfam database...	0.18	0.18	0.18	7	21281	39	4	29	6	32
RFA_00620	Telomerase-cil links to Rfam database...	0.66	0.64	0.68	25	21908	22	2	10	10	14
RFA_00626	rne5 links to Rfam database...	0.68	0.64	0.72	56	56538	30	6	16	8	31
RFA_00627	rne5 links to Rfam database...	0.61	0.60	0.62	52	56869	41	11	21	9	35
RFA_00628	rne5 links to Rfam database...	0.89	0.84	0.95	72	57215	15	0	4	11	14
RFA_00630	rne5 links to Rfam database...	0.69	0.67	0.72	58	56872	32	5	18	9	29
RFA_00639	7SK links to Rfam database...	0.29	0.29	0.29	25	54528	67	12	50	5	62
RFA_00814	R2_retro_el links to Rfam database...	0.51	0.51	0.51	21	25159	29	9	11	9	20
RFA_00815	R2_retro_el links to Rfam database...	0.41	0.41	0.41	17	24490	31	1	23	7	24
RFA_00816	R2_retro_el links to Rfam database...	0.58	0.63	0.53	26	23171	26	13	10	3	15
RFA_00817	R2_retro_el links to Rfam database...	0.24	0.27	0.22	11	21896	42	12	26	4	30
RFA_00818	R2_retro_el links to Rfam database...	0.21	0.22	0.21	9	20258	39	14	20	5	32
RFA_00819	R2_retro_el links to Rfam database...	0.60	0.68	0.53	28	27913	34	16	9	9	13
SRP_00016	Archaea_SRP links to Rfam database...	0.74	0.71	0.77	77	47795	24	5	18	1	32
SRP_00130	Archaea_SRP links to Rfam database...	0.51	0.48	0.55	47	49684	44	5	34	5	50
SRP_00142	Archaea_SRP links to Rfam database...	0.18	0.17	0.18	16	45968	72	8	64	0	77
SRP_00143	Archaea_SRP links to Rfam database...	0.65	0.62	0.68	63	49677	35	0	30	5	38
SRP_00144	Archaea_SRP links to Rfam database...	0.04	0.04	0.05	4	46578	83	17	66	0	90
SRP_00197	Archaea_SRP links to Rfam database...	0.23	0.21	0.25	21	49370	64	9	55	0	80
SRP_00198	Archaea_SRP links to Rfam database...	0.41	0.38	0.45	39	50954	47	5	42	0	64
SRP_00199	Archaea_SRP links to Rfam database...	0.24	0.23	0.26	24	50949	67	3	64	0	81
SRP_00201	Archaea_SRP links to Rfam database...	0.73	0.72	0.74	80	47787	30	3	25	2	31
SRP_00202	Archaea_SRP links to Rfam database...	0.52	0.49	0.56	57	54184	44	6	38	0	60
SRP_00203	Archaea_SRP links to Rfam database...	0.65	0.64	0.66	67	48727	39	4	30	5	38
SRP_00204	Archaea_SRP links to Rfam database...	0.56	0.53	0.59	54	49049	39	8	30	1	48
SRP_00206	Archaea_SRP links to Rfam database...	0.84	0.80	0.90	86	47799	11	5	5	1	22
SRP_00208	Archaea_SRP links to Rfam database...	0.47	0.45	0.49	45	46574	46	9	37	0	56
SRP_00255	Archaea_SRP links to Rfam database...	0.29	0.30	0.29	28	47489	69	11	58	0	66
SRP_00276	Archaea_SRP links to Rfam database...	0.66	0.63	0.70	69	50622	31	7	23	1	41
SRP_00278	Archaea_SRP links to Rfam database...	0.68	0.65	0.72	68	45961	29	4	23	2	37
SRP_00321	Archaea_SRP links to Rfam database...	0.48	0.45	0.50	49	47488	51	5	44	2	59
SRP_00322	Archaea_SRP links to Rfam database...	0.57	0.54	0.61	59	48419	38	1	37	0	50
SRP_00323	Archaea_SRP links to Rfam database...	0.75	0.69	0.82	74	47188	19	0	16	3	33
SRP_00330	Archaea_SRP links to Rfam database...	0.19	0.18	0.20	17	50002	67	11	56	0	78
SRP_00332	Archaea_SRP links to Rfam database...	0.10	0.09	0.10	10	50305	88	5	83	0	96
SRP_00339	Archaea_SRP links to Rfam database...	0.44	0.43	0.45	40	44462	51	6	43	2	54

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Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

Total Base Pair Counts
Total TP	1193
Total TN	2220645
Total FP	399
Total FP CONTRA	29
Total FP INCONS	348
Total FP COMP	22
Total FN	2999

Total Scores
MCC	0.464
Average MCC ± 95% Confidence Intervals	0.466 ± 0.043
Sensitivity	0.285
Positive Predictive Value	0.760
Nr of predictions	47

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2. Individual counts for CMfinder(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
CRW_00016	Intron_gpI links to Rfam database...	0.36	0.14	0.89	17	77402	2	0	2	0	103
CRW_00610	Intron_gpI links to Rfam database...	0.49	0.31	0.78	25	36283	7	1	6	0	56
CRW_00613	Intron_gpI links to Rfam database...	0.54	0.33	0.87	26	34950	4	0	4	0	52
CRW_00618	Intron_gpI links to Rfam database...	0.36	0.13	1.00	8	56272	0	0	0	0	53
CRW_00633	Intron_gpI links to Rfam database...	0.32	0.12	0.81	13	63530	3	1	2	0	93
CRW_00634	Intron_gpI links to Rfam database...	0.40	0.17	0.94	16	64603	1	0	1	0	78
CRW_00670	Intron_gpI links to Rfam database...	0.32	0.18	0.55	22	70085	18	0	18	0	98
CRW_00671	Intron_gpI links to Rfam database...	0.20	0.09	0.41	11	62808	16	0	16	0	106
CRW_00672	Intron_gpI links to Rfam database...	0.38	0.15	0.94	17	72372	1	0	1	0	94
CRW_00692	Intron_gpI links to Rfam database...	0.41	0.17	1.00	15	68620	0	0	0	0	75
PDB_00827	Intron_gpI links to Rfam database...	0.25	0.10	0.62	8	27015	5	0	5	0	73
RFA_00606	Telomerase-cil links to Rfam database...	0.34	0.21	0.57	8	21307	8	2	4	2	31
RFA_00620	Telomerase-cil links to Rfam database...	0.00	0.00	0.00	0	21939	6	0	6	0	39
RFA_00626	rne5 links to Rfam database...	0.44	0.32	0.60	28	56569	22	2	17	3	59
RFA_00627	rne5 links to Rfam database...	0.53	0.39	0.72	34	56906	15	3	10	2	53
RFA_00628	rne5 links to Rfam database...	0.58	0.43	0.77	37	57243	14	3	8	3	49
RFA_00630	rne5 links to Rfam database...	0.45	0.32	0.64	28	56909	17	3	13	1	59
RFA_00639	7SK links to Rfam database...	0.00	0.00	0.00	0	54575	44	6	34	4	87
RFA_00814	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	25177	2	0	2	0	20
RFA_00815	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	24508	2	0	2	0	20
RFA_00816	R2_retro_el links to Rfam database...	0.68	0.51	0.91	21	23197	2	0	2	0	20
RFA_00817	R2_retro_el links to Rfam database...	0.68	0.56	0.82	23	21917	5	0	5	0	18
RFA_00818	R2_retro_el links to Rfam database...	0.60	0.49	0.74	20	20274	8	1	6	1	21
RFA_00819	R2_retro_el links to Rfam database...	0.62	0.51	0.75	21	27938	7	0	7	0	20
SRP_00016	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	38	47849	8	0	8	0	71
SRP_00130	Archaea_SRP links to Rfam database...	0.50	0.32	0.78	31	49730	10	1	8	1	66
SRP_00142	Archaea_SRP links to Rfam database...	0.46	0.37	0.58	34	45997	26	1	24	1	59
SRP_00143	Archaea_SRP links to Rfam database...	0.50	0.30	0.86	30	49735	5	0	5	0	71
SRP_00144	Archaea_SRP links to Rfam database...	0.54	0.37	0.80	35	46621	11	0	9	2	59
SRP_00197	Archaea_SRP links to Rfam database...	0.46	0.26	0.84	26	49424	5	0	5	0	75
SRP_00198	Archaea_SRP links to Rfam database...	0.56	0.37	0.84	38	50995	7	0	7	0	65
SRP_00199	Archaea_SRP links to Rfam database...	0.54	0.35	0.82	37	50995	8	0	8	0	68
SRP_00201	Archaea_SRP links to Rfam database...	0.54	0.35	0.83	39	47848	8	0	8	0	72
SRP_00202	Archaea_SRP links to Rfam database...	0.43	0.21	0.86	25	54256	4	0	4	0	92
SRP_00203	Archaea_SRP links to Rfam database...	0.51	0.34	0.77	36	48781	12	0	11	1	69
SRP_00204	Archaea_SRP links to Rfam database...	0.52	0.34	0.80	35	49097	9	1	8	0	67
SRP_00206	Archaea_SRP links to Rfam database...	0.55	0.36	0.83	39	47848	8	0	8	0	69
SRP_00208	Archaea_SRP links to Rfam database...	0.52	0.33	0.83	33	46625	7	1	6	0	68
SRP_00255	Archaea_SRP links to Rfam database...	0.49	0.27	0.89	25	47558	3	0	3	0	69
SRP_00276	Archaea_SRP links to Rfam database...	0.51	0.33	0.80	36	50676	9	0	9	0	74
SRP_00278	Archaea_SRP links to Rfam database...	0.52	0.33	0.81	35	46013	8	0	8	0	70
SRP_00321	Archaea_SRP links to Rfam database...	0.42	0.21	0.82	23	47558	5	1	4	0	85
SRP_00322	Archaea_SRP links to Rfam database...	0.52	0.33	0.82	36	48472	8	0	8	0	73
SRP_00323	Archaea_SRP links to Rfam database...	0.54	0.34	0.88	36	47237	5	0	5	0	71
SRP_00330	Archaea_SRP links to Rfam database...	0.44	0.23	0.85	22	50060	5	0	4	1	73
SRP_00332	Archaea_SRP links to Rfam database...	0.44	0.25	0.75	27	50367	9	0	9	0	79
SRP_00339	Archaea_SRP links to Rfam database...	0.56	0.39	0.79	37	44504	10	2	8	0	57

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASLOpt - scored higher in this pairwise comparison

1. Total counts & total scores for RNASLOpt

2. Individual counts for RNASLOpt [ download as .csv ]

Performance of CMfinder(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for CMfinder(seed)

2. Individual counts for CMfinder(seed) [ download as .csv ]