CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASampler(20)		CRWrnafold
MCC	0.565	>	0.425
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043	>	0.426 ± 0.046
Sensitivity	0.413	<	0.427
Positive Predictive Value	0.772	>	0.424
Total TP	3079	<	3182
Total TN	4282091	>	4278572
Total FP	1146	<	4694
Total FP CONTRA	258	<	700
Total FP INCONS	649	<	3623
Total FP COMP	239	<	371
Total FN	4370	>	4267
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASampler(20) and CRWrnafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and CRWrnafold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and CRWrnafold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and CRWrnafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and CRWrnafold).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	3079
Total TN	4282091
Total FP	1146
Total FP CONTRA	258
Total FP INCONS	649
Total FP COMP	239
Total FN	4370

Total Scores
MCC	0.565
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043
Sensitivity	0.413
Positive Predictive Value	0.772
Nr of predictions	78

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

Total Base Pair Counts
Total TP	3182
Total TN	4278572
Total FP	4694
Total FP CONTRA	700
Total FP INCONS	3623
Total FP COMP	371
Total FN	4267

Total Scores
MCC	0.425
Average MCC ± 95% Confidence Intervals	0.426 ± 0.046
Sensitivity	0.427
Positive Predictive Value	0.424
Nr of predictions	78

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2. Individual counts for CRWrnafold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.35	0.35	0.35	31	45363	66	2	55	9	58
ASE_00090	RNaseP_bact_a links to Rfam database...	0.61	0.61	0.61	62	55510	44	2	37	5	39
ASE_00135	RNaseP_bact_a links to Rfam database...	0.46	0.46	0.46	50	63082	60	7	51	2	59
ASE_00153	RNaseP_nuc links to Rfam database...	0.68	0.68	0.67	50	57555	66	2	23	41	23
ASE_00215	RNaseP_bact_a links to Rfam database...	0.46	0.44	0.47	44	48422	51	4	46	1	55
ASE_00305	RNaseP_bact_b links to Rfam database...	0.52	0.55	0.49	47	54520	52	13	35	4	38
ASE_00328	RNaseP_bact_b links to Rfam database...	0.56	0.54	0.58	60	72668	47	7	36	4	52
ASE_00361	RNaseP_bact_a links to Rfam database...	0.47	0.45	0.50	57	75352	61	9	48	4	70
ASE_00427	RNaseP_nuc links to Rfam database...	0.15	0.20	0.12	9	40681	76	30	35	11	37
ASE_00441	RNaseP_bact_a links to Rfam database...	0.82	0.76	0.89	85	64166	20	1	9	10	27
SRP_00006	Metazoa_SRP links to Rfam database...	0.74	0.69	0.79	70	45664	24	1	18	5	31
SRP_00011	Plant_SRP links to Rfam database...	0.31	0.31	0.32	32	46259	69	6	63	0	72
SRP_00015	Plant_SRP links to Rfam database...	0.40	0.37	0.44	37	46275	54	1	47	6	62
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.65	0.63	0.66	55	37592	29	1	27	1	32
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.56	0.53	0.59	47	36776	39	0	33	6	41
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.71	0.70	0.71	62	36769	27	4	21	2	26
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.63	0.63	0.63	56	36226	37	3	30	4	33
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.45	0.45	0.45	39	36498	50	5	43	2	48
SRP_00050	Metazoa_SRP links to Rfam database...	0.76	0.74	0.78	73	44756	23	2	19	2	26
SRP_00066	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45360	91	10	81	0	100
SRP_00086	Metazoa_SRP links to Rfam database...	0.51	0.51	0.52	51	44155	49	3	44	2	49
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.63	0.65	0.61	58	34096	37	4	33	0	31
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.77	0.78	0.77	70	35687	21	4	17	0	20
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.67	0.67	0.68	60	35423	28	1	27	0	30
SRP_00102	Metazoa_SRP links to Rfam database...	0.41	0.40	0.43	40	44458	54	4	49	1	61
SRP_00103	Metazoa_SRP links to Rfam database...	0.47	0.46	0.47	47	45352	52	6	46	0	55
SRP_00152	Plant_SRP links to Rfam database...	0.49	0.48	0.51	49	45657	49	11	36	2	54
SRP_00171	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45350	101	15	86	0	88
SRP_00178	Plant_SRP links to Rfam database...	0.14	0.14	0.15	14	45660	79	4	75	0	88
SRP_00179	Plant_SRP links to Rfam database...	0.61	0.58	0.64	61	45960	38	4	31	3	44
SRP_00181	Plant_SRP links to Rfam database...	0.31	0.29	0.33	30	45966	60	5	55	0	72
SRP_00182	Plant_SRP links to Rfam database...	0.72	0.72	0.72	73	45954	32	9	20	3	28
SRP_00188	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	31050	75	8	67	0	79
SRP_00228	Metazoa_SRP links to Rfam database...	0.62	0.59	0.64	56	45364	38	2	29	7	39
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.81	0.81	0.81	70	36229	21	0	16	5	16
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.67	0.67	0.67	59	36227	29	4	25	0	29
SRP_00317	Metazoa_SRP links to Rfam database...	0.56	0.54	0.59	53	45060	39	3	34	2	45
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.33	0.44	0.25	17	35177	76	23	28	25	22
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.68	0.68	0.68	62	35420	31	1	28	2	29
SRP_00347	Metazoa_SRP links to Rfam database...	0.60	0.59	0.61	57	46572	40	5	31	4	39
SRP_00368	Metazoa_SRP links to Rfam database...	0.71	0.70	0.73	69	43861	29	2	24	3	29
TMR_00017	tmRNA links to Rfam database...	0.49	0.47	0.51	48	67067	52	11	35	6	54
TMR_00018	tmRNA links to Rfam database...	0.58	0.60	0.57	55	64523	47	13	29	5	37
TMR_00042	tmRNA links to Rfam database...	0.32	0.32	0.32	31	62739	68	8	57	3	67
TMR_00046	tmRNA links to Rfam database...	0.42	0.43	0.41	41	62736	64	12	46	6	55
TMR_00048	tmRNA links to Rfam database...	0.13	0.14	0.13	13	64876	98	11	80	7	82
TMR_00080	tmRNA links to Rfam database...	0.25	0.26	0.24	25	70396	79	21	58	0	71
TMR_00082	tmRNA links to Rfam database...	0.22	0.22	0.21	21	67798	83	19	58	6	75
TMR_00123	tmRNA links to Rfam database...	0.60	0.58	0.63	59	66336	40	6	29	5	42
TMR_00137	tmRNA links to Rfam database...	0.26	0.27	0.25	24	60978	77	17	56	4	65
TMR_00142	tmRNA links to Rfam database...	0.45	0.46	0.45	47	70771	69	16	42	11	55
TMR_00207	tmRNA links to Rfam database...	0.30	0.31	0.30	32	72282	83	7	69	7	71
TMR_00257	tmRNA links to Rfam database...	0.51	0.52	0.50	51	67058	57	10	42	5	47
TMR_00271	tmRNA links to Rfam database...	0.32	0.33	0.32	30	64166	73	10	55	8	61
TMR_00332	tmRNA links to Rfam database...	0.31	0.31	0.31	31	67062	76	14	54	8	68
TMR_00366	tmRNA links to Rfam database...	0.28	0.29	0.27	29	67789	85	19	59	7	71
TMR_00378	tmRNA links to Rfam database...	0.33	0.34	0.32	33	67792	78	13	58	7	64
TMR_00404	tmRNA links to Rfam database...	0.20	0.22	0.18	20	67418	93	24	66	3	72
TMR_00427	tmRNA links to Rfam database...	0.16	0.16	0.15	16	67421	96	15	76	5	81
TMR_00443	tmRNA links to Rfam database...	0.41	0.42	0.41	44	67053	72	15	49	8	60
TMR_00451	tmRNA links to Rfam database...	0.26	0.27	0.26	24	63454	75	9	59	7	65
TMR_00458	tmRNA links to Rfam database...	0.10	0.11	0.10	10	63450	94	8	78	8	83
TMR_00469	tmRNA links to Rfam database...	0.41	0.43	0.39	43	64511	66	15	51	0	57
TMR_00472	tmRNA links to Rfam database...	0.30	0.32	0.28	31	64509	82	20	60	2	66
TMR_00519	tmRNA links to Rfam database...	0.13	0.14	0.12	13	63083	94	17	77	0	82
TMR_00520	tmRNA links to Rfam database...	0.23	0.23	0.23	23	63088	87	8	71	8	76
TMR_00522	tmRNA links to Rfam database...	0.07	0.07	0.07	7	63085	104	14	84	6	90
TMR_00528	tmRNA links to Rfam database...	0.26	0.26	0.27	25	63096	77	16	53	8	72
TMR_00540	tmRNA links to Rfam database...	0.36	0.37	0.36	38	73429	70	18	51	1	66
TMR_00568	tmRNA links to Rfam database...	0.36	0.37	0.36	37	60622	72	15	52	5	62
TMR_00571	tmRNA links to Rfam database...	0.50	0.49	0.52	49	60631	55	6	40	9	50
TMR_00580	tmRNA links to Rfam database...	0.27	0.26	0.28	26	60633	75	6	61	8	74
TMR_00584	tmRNA links to Rfam database...	0.55	0.58	0.53	56	60969	53	10	40	3	41
TMR_00586	tmRNA links to Rfam database...	0.27	0.27	0.27	26	60978	76	12	59	5	71
TMR_00616	tmRNA links to Rfam database...	0.42	0.43	0.40	43	67054	70	10	54	6	56
TMR_00699	tmRNA links to Rfam database...	0.45	0.45	0.44	46	67057	58	10	48	0	56
TMR_00702	tmRNA links to Rfam database...	0.32	0.32	0.33	32	67063	70	8	58	4	68
TMR_00703	tmRNA links to Rfam database...	0.41	0.41	0.41	41	67427	62	9	51	2	58

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]

Performance of CRWrnafold - scored lower in this pairwise comparison

1. Total counts & total scores for CRWrnafold

2. Individual counts for CRWrnafold [ download as .csv ]