CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASampler(20)		CentroidFold
MCC	0.565	>	0.564
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043	<	0.554 ± 0.045
Sensitivity	0.413	<	0.513
Positive Predictive Value	0.772	>	0.623
Total TP	3079	<	3819
Total TN	4282091	>	4279943
Total FP	1146	<	2726
Total FP CONTRA	258	<	396
Total FP INCONS	649	<	1919
Total FP COMP	239	<	411
Total FN	4370	>	3630
P-value	0.85073699061

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Performance plots

Comparison of performance of RNASampler(20) and CentroidFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and CentroidFold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and CentroidFold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and CentroidFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and CentroidFold).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	3079
Total TN	4282091
Total FP	1146
Total FP CONTRA	258
Total FP INCONS	649
Total FP COMP	239
Total FN	4370

Total Scores
MCC	0.565
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043
Sensitivity	0.413
Positive Predictive Value	0.772
Nr of predictions	78

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Performance of CentroidFold - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidFold

Total Base Pair Counts
Total TP	3819
Total TN	4279943
Total FP	2726
Total FP CONTRA	396
Total FP INCONS	1919
Total FP COMP	411
Total FN	3630

Total Scores
MCC	0.564
Average MCC ± 95% Confidence Intervals	0.554 ± 0.045
Sensitivity	0.513
Positive Predictive Value	0.623
Nr of predictions	78

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2. Individual counts for CentroidFold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.66	0.57	0.77	51	45385	25	1	14	10	38
ASE_00090	RNaseP_bact_a links to Rfam database...	0.62	0.59	0.64	60	55517	39	4	30	5	41
ASE_00135	RNaseP_bact_a links to Rfam database...	0.60	0.51	0.70	56	63110	31	1	23	7	53
ASE_00153	RNaseP_nuc links to Rfam database...	0.46	0.42	0.51	31	57569	56	5	25	26	42
ASE_00215	RNaseP_bact_a links to Rfam database...	0.56	0.49	0.63	49	48438	30	2	27	1	50
ASE_00305	RNaseP_bact_b links to Rfam database...	0.73	0.61	0.87	52	54555	13	0	8	5	33
ASE_00328	RNaseP_bact_b links to Rfam database...	0.74	0.61	0.89	68	72695	13	1	7	5	44
ASE_00361	RNaseP_bact_a links to Rfam database...	0.56	0.50	0.63	63	75366	40	4	33	3	64
ASE_00427	RNaseP_nuc links to Rfam database...	0.17	0.17	0.16	8	40705	50	11	31	8	38
ASE_00441	RNaseP_bact_a links to Rfam database...	0.84	0.74	0.94	83	64173	9	0	5	4	29
SRP_00006	Metazoa_SRP links to Rfam database...	0.94	0.92	0.97	93	45657	6	0	3	3	8
SRP_00011	Plant_SRP links to Rfam database...	0.40	0.38	0.43	39	46270	52	5	46	1	65
SRP_00015	Plant_SRP links to Rfam database...	0.78	0.73	0.83	72	46273	19	2	13	4	27
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.48	0.45	0.53	39	37601	35	5	30	0	48
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.71	0.69	0.73	61	36772	27	4	19	4	27
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.78	0.78	0.78	69	36767	20	3	17	0	19
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.64	0.64	0.63	57	36225	36	5	28	3	32
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.63	0.61	0.65	53	36504	28	3	25	0	34
SRP_00050	Metazoa_SRP links to Rfam database...	0.93	0.91	0.95	90	44755	6	1	4	1	9
SRP_00066	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45359	92	8	84	0	100
SRP_00086	Metazoa_SRP links to Rfam database...	0.72	0.71	0.72	71	44155	29	1	26	2	29
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.75	0.71	0.80	63	34112	16	3	13	0	26
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.91	0.89	0.94	80	35693	5	1	4	0	10
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.83	0.81	0.85	73	35425	15	0	13	2	17
SRP_00102	Metazoa_SRP links to Rfam database...	0.78	0.75	0.81	76	44457	18	0	18	0	25
SRP_00103	Metazoa_SRP links to Rfam database...	0.57	0.53	0.61	54	45362	37	3	32	2	48
SRP_00152	Plant_SRP links to Rfam database...	0.54	0.49	0.61	50	45671	32	8	24	0	53
SRP_00171	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45405	46	8	38	0	88
SRP_00178	Plant_SRP links to Rfam database...	0.77	0.73	0.82	74	45663	18	6	10	2	28
SRP_00179	Plant_SRP links to Rfam database...	0.81	0.75	0.88	79	45966	15	4	7	4	26
SRP_00181	Plant_SRP links to Rfam database...	0.53	0.45	0.62	46	45982	28	4	24	0	56
SRP_00182	Plant_SRP links to Rfam database...	0.58	0.56	0.61	57	45962	40	10	27	3	44
SRP_00188	Plant_SRP links to Rfam database...	0.22	0.22	0.23	17	31050	58	7	51	0	62
SRP_00228	Metazoa_SRP links to Rfam database...	0.93	0.92	0.94	87	45358	12	0	6	6	8
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.80	0.79	0.82	68	36232	21	0	15	6	18
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.69	0.67	0.71	59	36232	27	5	19	3	29
SRP_00317	Metazoa_SRP links to Rfam database...	0.79	0.77	0.82	75	45058	23	0	17	6	23
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.32	0.44	0.23	17	35172	76	26	30	20	22
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.76	0.77	0.76	70	35419	25	2	20	3	21
SRP_00347	Metazoa_SRP links to Rfam database...	0.75	0.71	0.80	68	46580	19	4	13	2	28
SRP_00368	Metazoa_SRP links to Rfam database...	0.71	0.67	0.75	66	43868	25	5	17	3	32
TMR_00017	tmRNA links to Rfam database...	0.55	0.41	0.74	42	67104	19	0	15	4	60
TMR_00018	tmRNA links to Rfam database...	0.45	0.38	0.52	35	64553	36	10	22	4	57
TMR_00042	tmRNA links to Rfam database...	0.38	0.34	0.42	33	62757	48	6	39	3	65
TMR_00046	tmRNA links to Rfam database...	0.60	0.56	0.64	54	62750	37	4	27	6	42
TMR_00048	tmRNA links to Rfam database...	0.48	0.46	0.49	44	64890	55	8	38	9	51
TMR_00080	tmRNA links to Rfam database...	0.42	0.36	0.49	35	70428	37	7	30	0	61
TMR_00082	tmRNA links to Rfam database...	0.29	0.26	0.32	25	67818	53	9	44	0	71
TMR_00123	tmRNA links to Rfam database...	0.56	0.50	0.63	50	66350	35	3	27	5	51
TMR_00137	tmRNA links to Rfam database...	0.34	0.27	0.43	24	61019	40	3	29	8	65
TMR_00142	tmRNA links to Rfam database...	0.61	0.58	0.64	59	70784	46	8	25	13	43
TMR_00207	tmRNA links to Rfam database...	0.46	0.38	0.55	39	72319	37	4	28	5	64
TMR_00257	tmRNA links to Rfam database...	0.26	0.20	0.33	20	67101	45	1	39	5	78
TMR_00271	tmRNA links to Rfam database...	0.62	0.57	0.68	52	64184	36	6	19	11	39
TMR_00332	tmRNA links to Rfam database...	0.43	0.35	0.53	35	67095	36	1	30	5	64
TMR_00366	tmRNA links to Rfam database...	0.52	0.45	0.59	45	67820	42	11	20	11	55
TMR_00378	tmRNA links to Rfam database...	0.36	0.30	0.44	29	67830	47	8	29	10	68
TMR_00404	tmRNA links to Rfam database...	0.60	0.58	0.62	53	67443	49	6	26	17	39
TMR_00427	tmRNA links to Rfam database...	0.44	0.34	0.56	33	67469	31	8	18	5	64
TMR_00443	tmRNA links to Rfam database...	0.62	0.50	0.76	52	67093	23	6	10	7	52
TMR_00451	tmRNA links to Rfam database...	0.23	0.19	0.27	17	63483	50	12	34	4	72
TMR_00458	tmRNA links to Rfam database...	0.35	0.29	0.42	27	63481	45	8	30	7	66
TMR_00469	tmRNA links to Rfam database...	0.57	0.52	0.63	52	64537	35	10	21	4	48
TMR_00472	tmRNA links to Rfam database...	0.52	0.42	0.63	41	64555	29	6	18	5	56
TMR_00519	tmRNA links to Rfam database...	0.40	0.31	0.54	29	63136	38	5	20	13	66
TMR_00520	tmRNA links to Rfam database...	0.50	0.42	0.60	42	63120	38	4	24	10	57
TMR_00522	tmRNA links to Rfam database...	0.41	0.35	0.47	34	63118	47	8	30	9	63
TMR_00528	tmRNA links to Rfam database...	0.41	0.36	0.46	35	63114	51	12	29	10	62
TMR_00540	tmRNA links to Rfam database...	0.37	0.34	0.40	35	73449	60	7	45	8	69
TMR_00568	tmRNA links to Rfam database...	0.53	0.49	0.56	49	60639	44	4	34	6	50
TMR_00571	tmRNA links to Rfam database...	0.61	0.53	0.70	52	60652	30	6	16	8	47
TMR_00580	tmRNA links to Rfam database...	0.44	0.41	0.47	41	60638	50	10	37	3	59
TMR_00584	tmRNA links to Rfam database...	0.67	0.61	0.75	59	60996	30	1	19	10	38
TMR_00586	tmRNA links to Rfam database...	0.42	0.41	0.43	40	60981	59	10	44	5	57
TMR_00616	tmRNA links to Rfam database...	0.45	0.41	0.49	41	67078	50	9	33	8	58
TMR_00699	tmRNA links to Rfam database...	0.54	0.46	0.63	47	67086	33	3	25	5	55
TMR_00702	tmRNA links to Rfam database...	0.35	0.27	0.46	27	67102	39	5	27	7	73
TMR_00703	tmRNA links to Rfam database...	0.56	0.48	0.64	48	67453	34	5	22	7	51

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]

Performance of CentroidFold - scored lower in this pairwise comparison

1. Total counts & total scores for CentroidFold

2. Individual counts for CentroidFold [ download as .csv ]