CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASampler(20)		Contrafold
MCC	0.565	>	0.546
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043	<	0.541 ± 0.047
Sensitivity	0.413	<	0.536
Positive Predictive Value	0.772	>	0.559
Total TP	3079	<	3989
Total TN	4282091	>	4278938
Total FP	1146	<	3674
Total FP CONTRA	258	<	565
Total FP INCONS	649	<	2585
Total FP COMP	239	<	524
Total FN	4370	>	3460
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASampler(20) and Contrafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Contrafold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and Contrafold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Contrafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Contrafold).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	3079
Total TN	4282091
Total FP	1146
Total FP CONTRA	258
Total FP INCONS	649
Total FP COMP	239
Total FN	4370

Total Scores
MCC	0.565
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043
Sensitivity	0.413
Positive Predictive Value	0.772
Nr of predictions	78

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Performance of Contrafold - scored lower in this pairwise comparison

1. Total counts & total scores for Contrafold

Total Base Pair Counts
Total TP	3989
Total TN	4278938
Total FP	3674
Total FP CONTRA	565
Total FP INCONS	2585
Total FP COMP	524
Total FN	3460

Total Scores
MCC	0.546
Average MCC ± 95% Confidence Intervals	0.541 ± 0.047
Sensitivity	0.536
Positive Predictive Value	0.559
Nr of predictions	78

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2. Individual counts for Contrafold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.60	0.56	0.65	50	45374	37	2	25	10	39
ASE_00090	RNaseP_bact_a links to Rfam database...	0.67	0.67	0.66	68	55508	43	4	31	8	33
ASE_00135	RNaseP_bact_a links to Rfam database...	0.63	0.57	0.69	62	63100	35	1	27	7	47
ASE_00153	RNaseP_nuc links to Rfam database...	0.41	0.42	0.40	31	57553	80	7	39	34	42
ASE_00215	RNaseP_bact_a links to Rfam database...	0.54	0.51	0.57	50	48429	39	4	33	2	49
ASE_00305	RNaseP_bact_b links to Rfam database...	0.70	0.61	0.80	52	54550	20	0	13	7	33
ASE_00328	RNaseP_bact_b links to Rfam database...	0.63	0.59	0.67	66	72673	41	5	27	9	46
ASE_00361	RNaseP_bact_a links to Rfam database...	0.64	0.61	0.67	77	75351	42	8	30	4	50
ASE_00427	RNaseP_nuc links to Rfam database...	0.14	0.17	0.11	8	40684	76	26	37	13	38
ASE_00441	RNaseP_bact_a links to Rfam database...	0.82	0.76	0.89	85	64166	20	2	8	10	27
SRP_00006	Metazoa_SRP links to Rfam database...	0.97	0.96	0.97	97	45653	11	0	3	8	4
SRP_00011	Plant_SRP links to Rfam database...	0.38	0.38	0.39	39	46260	62	5	56	1	65
SRP_00015	Plant_SRP links to Rfam database...	0.78	0.77	0.80	76	46265	26	2	17	7	23
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.44	0.44	0.44	38	37588	49	8	41	0	49
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.70	0.70	0.69	62	36766	34	5	23	6	26
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.78	0.78	0.78	69	36767	22	3	17	2	19
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.63	0.65	0.61	58	36220	42	5	32	5	31
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.63	0.64	0.61	56	36493	38	5	31	2	31
SRP_00050	Metazoa_SRP links to Rfam database...	0.92	0.91	0.94	90	44754	9	1	5	3	9
SRP_00066	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45352	99	10	89	0	100
SRP_00086	Metazoa_SRP links to Rfam database...	0.73	0.73	0.74	73	44154	29	1	25	3	27
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.70	0.71	0.69	63	34100	29	4	24	1	26
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.92	0.92	0.92	83	35688	7	1	6	0	7
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.84	0.84	0.84	76	35420	20	0	15	5	14
SRP_00102	Metazoa_SRP links to Rfam database...	0.75	0.75	0.75	76	44450	26	1	24	1	25
SRP_00103	Metazoa_SRP links to Rfam database...	0.53	0.53	0.52	54	45348	51	4	45	2	48
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.51	0.52	53	45651	49	10	39	0	50
SRP_00171	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45365	86	13	73	0	88
SRP_00178	Plant_SRP links to Rfam database...	0.77	0.76	0.77	78	45652	26	7	16	3	24
SRP_00179	Plant_SRP links to Rfam database...	0.80	0.79	0.81	83	45954	23	5	14	4	22
SRP_00181	Plant_SRP links to Rfam database...	0.53	0.48	0.58	49	45972	36	5	30	1	53
SRP_00182	Plant_SRP links to Rfam database...	0.58	0.58	0.58	59	45955	45	10	32	3	42
SRP_00188	Plant_SRP links to Rfam database...	0.21	0.22	0.21	17	31045	63	8	55	0	62
SRP_00228	Metazoa_SRP links to Rfam database...	0.94	0.94	0.94	89	45356	16	0	6	10	6
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.79	0.79	0.79	68	36229	27	0	18	9	18
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.66	0.68	0.64	60	36221	37	6	28	3	28
SRP_00317	Metazoa_SRP links to Rfam database...	0.78	0.77	0.79	75	45055	29	0	20	9	23
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.32	0.44	0.23	17	35171	79	26	31	22	22
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.76	0.77	0.76	70	35419	28	2	20	6	21
SRP_00347	Metazoa_SRP links to Rfam database...	0.78	0.78	0.79	75	46570	24	4	16	4	21
SRP_00368	Metazoa_SRP links to Rfam database...	0.68	0.67	0.69	66	43861	32	5	24	3	32
TMR_00017	tmRNA links to Rfam database...	0.49	0.44	0.54	45	67078	42	5	33	4	57
TMR_00018	tmRNA links to Rfam database...	0.38	0.37	0.40	34	64535	55	13	38	4	58
TMR_00042	tmRNA links to Rfam database...	0.29	0.30	0.29	29	62736	74	13	57	4	69
TMR_00046	tmRNA links to Rfam database...	0.60	0.58	0.62	56	62745	44	6	28	10	40
TMR_00048	tmRNA links to Rfam database...	0.40	0.41	0.40	39	64882	69	13	46	10	56
TMR_00080	tmRNA links to Rfam database...	0.43	0.42	0.44	40	70410	50	15	35	0	56
TMR_00082	tmRNA links to Rfam database...	0.29	0.28	0.30	27	67807	64	9	53	2	69
TMR_00123	tmRNA links to Rfam database...	0.53	0.51	0.55	52	66335	52	4	39	9	49
TMR_00137	tmRNA links to Rfam database...	0.37	0.34	0.41	30	61001	53	6	38	9	59
TMR_00142	tmRNA links to Rfam database...	0.57	0.58	0.56	59	70771	61	13	33	15	43
TMR_00207	tmRNA links to Rfam database...	0.43	0.40	0.48	41	72304	50	5	40	5	62
TMR_00257	tmRNA links to Rfam database...	0.25	0.22	0.27	22	67080	65	2	57	6	76
TMR_00271	tmRNA links to Rfam database...	0.64	0.62	0.67	56	64177	40	6	22	12	35
TMR_00332	tmRNA links to Rfam database...	0.45	0.40	0.50	40	67081	45	2	38	5	59
TMR_00366	tmRNA links to Rfam database...	0.52	0.50	0.53	50	67802	55	12	32	11	50
TMR_00378	tmRNA links to Rfam database...	0.24	0.25	0.24	24	67797	86	17	58	11	73
TMR_00404	tmRNA links to Rfam database...	0.56	0.58	0.55	53	67431	62	11	33	18	39
TMR_00427	tmRNA links to Rfam database...	0.45	0.42	0.48	41	67443	49	10	34	5	56
TMR_00443	tmRNA links to Rfam database...	0.57	0.51	0.65	53	67079	36	6	23	7	51
TMR_00451	tmRNA links to Rfam database...	0.19	0.19	0.18	17	63453	80	18	58	4	72
TMR_00458	tmRNA links to Rfam database...	0.32	0.30	0.35	28	63465	60	11	42	7	65
TMR_00469	tmRNA links to Rfam database...	0.53	0.53	0.53	53	64520	51	13	34	4	47
TMR_00472	tmRNA links to Rfam database...	0.64	0.64	0.64	62	64523	43	12	23	8	35
TMR_00519	tmRNA links to Rfam database...	0.33	0.32	0.35	30	63105	69	8	47	14	65
TMR_00520	tmRNA links to Rfam database...	0.44	0.41	0.48	41	63104	56	9	36	11	58
TMR_00522	tmRNA links to Rfam database...	0.36	0.35	0.38	34	63100	65	12	44	9	63
TMR_00528	tmRNA links to Rfam database...	0.36	0.36	0.35	35	63091	75	20	44	11	62
TMR_00540	tmRNA links to Rfam database...	0.35	0.35	0.36	36	73436	76	10	54	12	68
TMR_00568	tmRNA links to Rfam database...	0.51	0.51	0.53	50	60631	51	6	39	6	49
TMR_00571	tmRNA links to Rfam database...	0.65	0.64	0.66	63	60631	44	7	25	12	36
TMR_00580	tmRNA links to Rfam database...	0.41	0.41	0.41	41	60625	63	15	45	3	59
TMR_00584	tmRNA links to Rfam database...	0.63	0.61	0.65	59	60984	45	3	29	13	38
TMR_00586	tmRNA links to Rfam database...	0.41	0.41	0.41	40	60977	63	11	47	5	57
TMR_00616	tmRNA links to Rfam database...	0.42	0.41	0.42	41	67063	65	12	45	8	58
TMR_00699	tmRNA links to Rfam database...	0.67	0.62	0.72	63	67074	29	4	20	5	39
TMR_00702	tmRNA links to Rfam database...	0.36	0.32	0.40	32	67081	57	5	43	9	68
TMR_00703	tmRNA links to Rfam database...	0.59	0.56	0.62	55	67439	43	6	28	9	44

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]

Performance of Contrafold - scored lower in this pairwise comparison

1. Total counts & total scores for Contrafold

2. Individual counts for Contrafold [ download as .csv ]