CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASampler(20)		Fold
MCC	0.565	>	0.524
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043	>	0.523 ± 0.052
Sensitivity	0.413	<	0.528
Positive Predictive Value	0.772	>	0.523
Total TP	3079	<	3933
Total TN	4282091	>	4278550
Total FP	1146	<	4097
Total FP CONTRA	258	<	631
Total FP INCONS	649	<	2963
Total FP COMP	239	<	503
Total FN	4370	>	3516
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASampler(20) and Fold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Fold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and Fold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Fold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Fold).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	3079
Total TN	4282091
Total FP	1146
Total FP CONTRA	258
Total FP INCONS	649
Total FP COMP	239
Total FN	4370

Total Scores
MCC	0.565
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043
Sensitivity	0.413
Positive Predictive Value	0.772
Nr of predictions	78

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Performance of Fold - scored lower in this pairwise comparison

1. Total counts & total scores for Fold

Total Base Pair Counts
Total TP	3933
Total TN	4278550
Total FP	4097
Total FP CONTRA	631
Total FP INCONS	2963
Total FP COMP	503
Total FN	3516

Total Scores
MCC	0.524
Average MCC ± 95% Confidence Intervals	0.523 ± 0.052
Sensitivity	0.528
Positive Predictive Value	0.523
Nr of predictions	78

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2. Individual counts for Fold [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.37	0.38	0.36	34	45357	67	6	54	7	55
ASE_00090	RNaseP_bact_a links to Rfam database...	0.66	0.66	0.65	67	55508	43	4	32	7	34
ASE_00135	RNaseP_bact_a links to Rfam database...	0.49	0.48	0.50	52	63086	59	7	45	7	57
ASE_00153	RNaseP_nuc links to Rfam database...	0.57	0.60	0.54	44	57549	73	9	28	36	29
ASE_00215	RNaseP_bact_a links to Rfam database...	0.60	0.58	0.62	57	48424	39	5	30	4	42
ASE_00305	RNaseP_bact_b links to Rfam database...	0.55	0.53	0.56	45	54535	48	4	31	13	40
ASE_00328	RNaseP_bact_b links to Rfam database...	0.68	0.65	0.72	73	72669	43	4	25	14	39
ASE_00361	RNaseP_bact_a links to Rfam database...	0.52	0.51	0.53	65	75343	61	11	47	3	62
ASE_00427	RNaseP_nuc links to Rfam database...	0.16	0.20	0.14	9	40691	80	18	37	25	37
ASE_00441	RNaseP_bact_a links to Rfam database...	0.81	0.77	0.86	86	64161	24	1	13	10	26
SRP_00006	Metazoa_SRP links to Rfam database...	0.85	0.84	0.86	85	45654	17	3	11	3	16
SRP_00011	Plant_SRP links to Rfam database...	0.69	0.69	0.69	72	46255	33	2	31	0	32
SRP_00015	Plant_SRP links to Rfam database...	0.83	0.80	0.86	79	46268	20	0	13	7	20
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.78	0.80	0.76	70	37583	23	7	15	1	17
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.72	0.69	0.74	61	36774	27	0	21	6	27
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.78	0.81	0.76	71	36762	25	5	18	2	17
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.68	0.70	0.67	62	36223	33	4	26	3	27
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.67	0.68	0.67	59	36497	32	5	24	3	28
SRP_00050	Metazoa_SRP links to Rfam database...	0.96	0.94	0.98	93	44755	4	0	2	2	6
SRP_00066	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45357	94	10	84	0	100
SRP_00086	Metazoa_SRP links to Rfam database...	0.58	0.60	0.57	60	44148	46	3	42	1	40
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.69	0.71	0.67	63	34097	31	3	28	0	26
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.72	0.73	0.72	66	35686	26	2	24	0	24
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.27	0.27	0.27	24	35422	66	5	60	1	66
SRP_00102	Metazoa_SRP links to Rfam database...	0.77	0.75	0.78	76	44454	24	0	21	3	25
SRP_00103	Metazoa_SRP links to Rfam database...	0.17	0.17	0.17	17	45350	84	8	76	0	85
SRP_00152	Plant_SRP links to Rfam database...	0.70	0.68	0.71	70	45655	30	1	27	2	33
SRP_00171	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45351	100	15	85	0	88
SRP_00178	Plant_SRP links to Rfam database...	0.80	0.77	0.82	79	45657	19	1	16	2	23
SRP_00179	Plant_SRP links to Rfam database...	0.76	0.75	0.77	79	45953	28	5	19	4	26
SRP_00181	Plant_SRP links to Rfam database...	0.36	0.35	0.37	36	45958	62	4	58	0	66
SRP_00182	Plant_SRP links to Rfam database...	0.67	0.65	0.68	66	45959	34	5	26	3	35
SRP_00188	Plant_SRP links to Rfam database...	0.16	0.16	0.16	13	31045	67	6	61	0	66
SRP_00228	Metazoa_SRP links to Rfam database...	0.98	0.98	0.98	93	45356	11	0	2	9	2
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.84	0.85	0.84	73	36228	20	0	14	6	13
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.73	0.74	0.72	65	36225	26	2	23	1	23
SRP_00317	Metazoa_SRP links to Rfam database...	0.88	0.86	0.91	84	45058	15	0	8	7	14
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.31	0.44	0.22	17	35169	79	27	32	20	22
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.77	0.76	0.78	69	35423	21	0	19	2	22
SRP_00347	Metazoa_SRP links to Rfam database...	0.76	0.78	0.75	75	46565	30	3	22	5	21
SRP_00368	Metazoa_SRP links to Rfam database...	0.90	0.90	0.91	88	43859	12	1	8	3	10
TMR_00017	tmRNA links to Rfam database...	0.56	0.55	0.58	56	67064	45	8	33	4	46
TMR_00018	tmRNA links to Rfam database...	0.41	0.42	0.40	39	64522	63	14	45	4	53
TMR_00042	tmRNA links to Rfam database...	0.34	0.35	0.34	34	62736	68	3	62	3	64
TMR_00046	tmRNA links to Rfam database...	0.27	0.28	0.26	27	62732	80	11	65	4	69
TMR_00048	tmRNA links to Rfam database...	0.23	0.24	0.22	23	64877	85	17	63	5	72
TMR_00080	tmRNA links to Rfam database...	0.61	0.61	0.61	59	70403	41	10	28	3	37
TMR_00082	tmRNA links to Rfam database...	0.67	0.67	0.68	64	67802	37	9	21	7	32
TMR_00123	tmRNA links to Rfam database...	0.44	0.45	0.44	45	66328	62	10	47	5	56
TMR_00137	tmRNA links to Rfam database...	0.16	0.17	0.15	15	60978	90	11	71	8	74
TMR_00142	tmRNA links to Rfam database...	0.49	0.51	0.48	52	70767	69	13	44	12	50
TMR_00207	tmRNA links to Rfam database...	0.30	0.30	0.30	31	72287	76	8	64	4	72
TMR_00257	tmRNA links to Rfam database...	0.27	0.28	0.26	27	67058	81	14	62	5	71
TMR_00271	tmRNA links to Rfam database...	0.63	0.62	0.65	56	64175	41	6	24	11	35
TMR_00332	tmRNA links to Rfam database...	0.48	0.48	0.48	48	67061	56	14	38	4	51
TMR_00366	tmRNA links to Rfam database...	0.46	0.46	0.46	46	67796	65	14	40	11	54
TMR_00378	tmRNA links to Rfam database...	0.29	0.30	0.28	29	67792	86	19	56	11	68
TMR_00404	tmRNA links to Rfam database...	0.37	0.40	0.34	37	67420	82	28	43	11	55
TMR_00427	tmRNA links to Rfam database...	0.27	0.28	0.26	27	67424	82	18	59	5	70
TMR_00443	tmRNA links to Rfam database...	0.53	0.50	0.55	52	67067	49	11	31	7	52
TMR_00451	tmRNA links to Rfam database...	0.18	0.19	0.17	17	63444	89	19	66	4	72
TMR_00458	tmRNA links to Rfam database...	0.49	0.49	0.48	46	63451	56	10	39	7	47
TMR_00469	tmRNA links to Rfam database...	0.34	0.34	0.33	34	64518	77	10	58	9	66
TMR_00472	tmRNA links to Rfam database...	0.48	0.49	0.47	48	64518	67	11	43	13	49
TMR_00519	tmRNA links to Rfam database...	0.18	0.20	0.17	19	63079	102	18	74	10	76
TMR_00520	tmRNA links to Rfam database...	0.48	0.48	0.48	48	63091	61	15	36	10	51
TMR_00522	tmRNA links to Rfam database...	0.38	0.39	0.38	38	63089	72	15	48	9	59
TMR_00528	tmRNA links to Rfam database...	0.30	0.29	0.30	28	63098	74	15	49	10	69
TMR_00540	tmRNA links to Rfam database...	0.45	0.44	0.47	46	73438	66	11	41	14	58
TMR_00568	tmRNA links to Rfam database...	0.35	0.34	0.36	34	60632	66	5	55	6	65
TMR_00571	tmRNA links to Rfam database...	0.61	0.60	0.63	59	60632	48	5	30	13	40
TMR_00580	tmRNA links to Rfam database...	0.67	0.65	0.70	65	60633	40	3	25	12	35
TMR_00584	tmRNA links to Rfam database...	0.61	0.60	0.62	58	60981	48	3	33	12	39
TMR_00586	tmRNA links to Rfam database...	0.48	0.49	0.47	48	60973	63	8	46	9	49
TMR_00616	tmRNA links to Rfam database...	0.33	0.34	0.32	34	67054	78	16	57	5	65
TMR_00699	tmRNA links to Rfam database...	0.55	0.53	0.57	54	67067	45	6	34	5	48
TMR_00702	tmRNA links to Rfam database...	0.45	0.44	0.46	44	67066	55	15	36	4	56
TMR_00703	tmRNA links to Rfam database...	0.49	0.49	0.49	49	67428	56	12	39	5	50

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]

Performance of Fold - scored lower in this pairwise comparison

1. Total counts & total scores for Fold

2. Individual counts for Fold [ download as .csv ]