CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASampler(20)		RNASLOpt
MCC	0.565	>	0.393
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043	>	0.392 ± 0.044
Sensitivity	0.413	>	0.372
Positive Predictive Value	0.772	>	0.417
Total TP	3079	>	2773
Total TN	4282091	>	4279426
Total FP	1146	<	4174
Total FP CONTRA	258	<	594
Total FP INCONS	649	<	3284
Total FP COMP	239	<	296
Total FN	4370	<	4676
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASampler(20) and RNASLOpt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and RNASLOpt).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and RNASLOpt).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and RNASLOpt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and RNASLOpt).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	3079
Total TN	4282091
Total FP	1146
Total FP CONTRA	258
Total FP INCONS	649
Total FP COMP	239
Total FN	4370

Total Scores
MCC	0.565
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043
Sensitivity	0.413
Positive Predictive Value	0.772
Nr of predictions	78

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Performance of RNASLOpt - scored lower in this pairwise comparison

1. Total counts & total scores for RNASLOpt

Total Base Pair Counts
Total TP	2773
Total TN	4279426
Total FP	4174
Total FP CONTRA	594
Total FP INCONS	3284
Total FP COMP	296
Total FN	4676

Total Scores
MCC	0.393
Average MCC ± 95% Confidence Intervals	0.392 ± 0.044
Sensitivity	0.372
Positive Predictive Value	0.417
Nr of predictions	78

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2. Individual counts for RNASLOpt [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.49	0.46	0.52	41	45372	43	4	34	5	48
ASE_00090	RNaseP_bact_a links to Rfam database...	0.46	0.45	0.47	45	55515	52	8	43	1	56
ASE_00135	RNaseP_bact_a links to Rfam database...	0.32	0.29	0.34	32	63097	66	3	58	5	77
ASE_00153	RNaseP_nuc links to Rfam database...	0.49	0.53	0.46	39	57545	68	15	31	22	34
ASE_00215	RNaseP_bact_a links to Rfam database...	0.54	0.48	0.59	48	48435	34	3	30	1	51
ASE_00305	RNaseP_bact_b links to Rfam database...	0.56	0.56	0.56	48	54530	44	4	33	7	37
ASE_00328	RNaseP_bact_b links to Rfam database...	0.58	0.54	0.63	60	72676	39	5	30	4	52
ASE_00361	RNaseP_bact_a links to Rfam database...	0.51	0.46	0.56	59	75360	48	2	45	1	68
ASE_00427	RNaseP_nuc links to Rfam database...	0.00	0.00	0.00	0	40690	69	32	33	4	46
ASE_00441	RNaseP_bact_a links to Rfam database...	0.55	0.49	0.62	55	64172	34	3	31	0	57
SRP_00006	Metazoa_SRP links to Rfam database...	0.17	0.16	0.19	16	45670	67	8	59	0	85
SRP_00011	Plant_SRP links to Rfam database...	0.17	0.16	0.19	17	46271	72	8	64	0	87
SRP_00015	Plant_SRP links to Rfam database...	0.28	0.25	0.31	25	46279	57	7	49	1	74
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.73	0.69	0.78	60	37598	18	2	15	1	27
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.40	0.36	0.45	32	36785	44	1	38	5	56
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.11	0.10	0.13	9	36787	61	4	56	1	79
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.40	0.37	0.44	33	36240	42	4	38	0	56
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.37	0.36	0.39	31	36506	49	10	38	1	56
SRP_00050	Metazoa_SRP links to Rfam database...	0.60	0.54	0.68	53	44772	27	0	25	2	46
SRP_00066	Metazoa_SRP links to Rfam database...	0.16	0.15	0.17	15	45361	75	6	69	0	85
SRP_00086	Metazoa_SRP links to Rfam database...	0.53	0.49	0.57	49	44167	40	1	36	3	51
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.77	0.73	0.82	65	34112	14	1	13	0	24
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.84	0.76	0.94	68	35706	4	0	4	0	22
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.79	0.74	0.85	67	35432	15	1	11	3	23
SRP_00102	Metazoa_SRP links to Rfam database...	0.41	0.38	0.46	38	44468	45	4	41	0	63
SRP_00103	Metazoa_SRP links to Rfam database...	0.78	0.74	0.82	75	45360	16	1	15	0	27
SRP_00152	Plant_SRP links to Rfam database...	0.23	0.21	0.26	22	45667	64	10	54	0	81
SRP_00171	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45358	93	16	77	0	88
SRP_00178	Plant_SRP links to Rfam database...	0.11	0.10	0.12	10	45669	74	1	73	0	92
SRP_00179	Plant_SRP links to Rfam database...	0.65	0.59	0.72	62	45970	27	3	21	3	43
SRP_00181	Plant_SRP links to Rfam database...	0.08	0.07	0.09	7	45975	74	2	72	0	95
SRP_00182	Plant_SRP links to Rfam database...	0.54	0.51	0.57	52	45965	39	11	28	0	49
SRP_00188	Plant_SRP links to Rfam database...	0.18	0.18	0.20	14	31054	57	9	48	0	65
SRP_00228	Metazoa_SRP links to Rfam database...	0.69	0.62	0.77	59	45374	24	2	16	6	36
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.66	0.60	0.71	52	36242	23	0	21	2	34
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.14	0.14	0.15	12	36233	70	11	59	0	76
SRP_00317	Metazoa_SRP links to Rfam database...	0.20	0.19	0.21	19	45061	72	7	63	2	79
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.19	0.26	0.14	10	35176	76	24	35	17	29
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.76	0.71	0.80	65	35430	17	2	14	1	26
SRP_00347	Metazoa_SRP links to Rfam database...	0.46	0.44	0.49	42	46580	45	4	39	2	54
SRP_00368	Metazoa_SRP links to Rfam database...	0.76	0.68	0.85	67	43877	14	1	11	2	31
TMR_00017	tmRNA links to Rfam database...	0.29	0.27	0.32	28	67073	64	7	53	4	74
TMR_00018	tmRNA links to Rfam database...	0.36	0.36	0.36	33	64528	61	12	47	2	59
TMR_00042	tmRNA links to Rfam database...	0.30	0.30	0.31	29	62742	66	10	54	2	69
TMR_00046	tmRNA links to Rfam database...	0.40	0.40	0.41	38	62742	59	10	45	4	58
TMR_00048	tmRNA links to Rfam database...	0.53	0.53	0.54	50	64887	48	15	28	5	45
TMR_00080	tmRNA links to Rfam database...	0.26	0.27	0.26	26	70399	75	26	49	0	70
TMR_00082	tmRNA links to Rfam database...	0.57	0.54	0.59	52	67808	39	12	24	3	44
TMR_00123	tmRNA links to Rfam database...	0.43	0.39	0.47	39	66347	49	5	39	5	62
TMR_00137	tmRNA links to Rfam database...	0.18	0.19	0.18	17	60980	79	17	61	1	72
TMR_00142	tmRNA links to Rfam database...	0.55	0.52	0.58	53	70785	47	8	30	9	49
TMR_00207	tmRNA links to Rfam database...	0.10	0.10	0.11	10	72296	88	6	78	4	93
TMR_00257	tmRNA links to Rfam database...	0.26	0.24	0.28	24	67074	68	9	54	5	74
TMR_00271	tmRNA links to Rfam database...	0.41	0.38	0.43	35	64180	53	15	31	7	56
TMR_00332	tmRNA links to Rfam database...	0.31	0.28	0.34	28	67079	58	9	45	4	71
TMR_00366	tmRNA links to Rfam database...	0.44	0.42	0.47	42	67806	52	11	37	4	58
TMR_00378	tmRNA links to Rfam database...	0.42	0.40	0.44	39	67808	53	12	37	4	58
TMR_00404	tmRNA links to Rfam database...	0.35	0.37	0.34	34	67428	74	11	55	8	58
TMR_00427	tmRNA links to Rfam database...	0.38	0.37	0.40	36	67438	61	8	46	7	61
TMR_00443	tmRNA links to Rfam database...	0.32	0.28	0.36	29	67080	58	5	47	6	75
TMR_00451	tmRNA links to Rfam database...	0.25	0.22	0.28	20	63475	55	7	44	4	69
TMR_00458	tmRNA links to Rfam database...	0.26	0.25	0.28	23	63464	69	8	51	10	70
TMR_00469	tmRNA links to Rfam database...	0.34	0.33	0.35	33	64525	62	10	52	0	67
TMR_00472	tmRNA links to Rfam database...	0.23	0.24	0.23	23	64522	77	18	57	2	74
TMR_00519	tmRNA links to Rfam database...	0.24	0.24	0.24	23	63095	82	13	59	10	72
TMR_00520	tmRNA links to Rfam database...	0.31	0.29	0.33	29	63102	70	5	54	11	70
TMR_00522	tmRNA links to Rfam database...	0.25	0.24	0.27	23	63104	74	11	52	11	74
TMR_00528	tmRNA links to Rfam database...	0.13	0.12	0.14	12	63102	86	8	68	10	85
TMR_00540	tmRNA links to Rfam database...	0.44	0.42	0.45	44	73438	55	15	39	1	60
TMR_00568	tmRNA links to Rfam database...	0.33	0.31	0.34	31	60635	66	9	51	6	68
TMR_00571	tmRNA links to Rfam database...	0.35	0.33	0.38	33	60639	62	8	46	8	66
TMR_00580	tmRNA links to Rfam database...	0.37	0.34	0.40	34	60642	55	8	42	5	66
TMR_00584	tmRNA links to Rfam database...	0.46	0.43	0.48	42	60988	52	5	40	7	55
TMR_00586	tmRNA links to Rfam database...	0.46	0.38	0.55	37	61008	35	1	29	5	60
TMR_00616	tmRNA links to Rfam database...	0.44	0.43	0.46	43	67067	56	8	43	5	56
TMR_00699	tmRNA links to Rfam database...	0.52	0.45	0.61	46	67085	34	0	30	4	56
TMR_00702	tmRNA links to Rfam database...	0.41	0.38	0.44	38	67074	56	7	42	7	62
TMR_00703	tmRNA links to Rfam database...	0.26	0.24	0.29	24	67444	64	5	55	4	75

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]

Performance of RNASLOpt - scored lower in this pairwise comparison

1. Total counts & total scores for RNASLOpt

2. Individual counts for RNASLOpt [ download as .csv ]