CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASampler(20)		RNAshapes
MCC	0.565	>	0.412
Average MCC ± 95% Confidence Intervals	0.539 ± 0.044	>	0.413 ± 0.053
Sensitivity	0.413	>	0.410
Positive Predictive Value	0.775	>	0.416
Total TP	3033	>	3013
Total TN	4214266	>	4210931
Total FP	1110	<	4605
Total FP CONTRA	246	<	670
Total FP INCONS	636	<	3567
Total FP COMP	228	<	368
Total FN	4316	<	4336
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASampler(20) and RNAshapes. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and RNAshapes).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and RNAshapes).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and RNAshapes. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and RNAshapes).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	3033
Total TN	4214266
Total FP	1110
Total FP CONTRA	246
Total FP INCONS	636
Total FP COMP	228
Total FN	4316

Total Scores
MCC	0.565
Average MCC ± 95% Confidence Intervals	0.539 ± 0.044
Sensitivity	0.413
Positive Predictive Value	0.775
Nr of predictions	77

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Performance of RNAshapes - scored lower in this pairwise comparison

1. Total counts & total scores for RNAshapes

Total Base Pair Counts
Total TP	3013
Total TN	4210931
Total FP	4605
Total FP CONTRA	670
Total FP INCONS	3567
Total FP COMP	368
Total FN	4336

Total Scores
MCC	0.412
Average MCC ± 95% Confidence Intervals	0.413 ± 0.053
Sensitivity	0.410
Positive Predictive Value	0.416
Nr of predictions	77

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2. Individual counts for RNAshapes [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.48	0.46	0.50	41	45369	49	2	39	8	48
ASE_00090	RNaseP_bact_a links to Rfam database...	0.52	0.51	0.52	52	55511	54	3	45	6	49
ASE_00135	RNaseP_bact_a links to Rfam database...	0.47	0.44	0.49	48	63093	56	4	45	7	61
ASE_00153	RNaseP_nuc links to Rfam database...	0.35	0.40	0.32	29	57538	88	15	48	25	44
ASE_00215	RNaseP_bact_a links to Rfam database...	0.53	0.51	0.56	50	48426	43	2	38	3	49
ASE_00305	RNaseP_bact_b links to Rfam database...	0.40	0.42	0.39	36	54522	61	14	43	4	49
ASE_00328	RNaseP_bact_b links to Rfam database...	0.59	0.55	0.63	62	72672	45	3	34	8	50
ASE_00361	RNaseP_bact_a links to Rfam database...	0.49	0.47	0.51	60	75348	61	11	47	3	67
ASE_00427	RNaseP_nuc links to Rfam database...	0.08	0.11	0.07	5	40680	84	23	47	14	41
ASE_00441	RNaseP_bact_a links to Rfam database...	0.68	0.63	0.74	71	64165	33	4	21	8	41
SRP_00006	Metazoa_SRP links to Rfam database...	0.91	0.89	0.94	90	45657	11	0	6	5	11
SRP_00011	Plant_SRP links to Rfam database...	0.47	0.44	0.50	46	46268	48	3	43	2	58
SRP_00015	Plant_SRP links to Rfam database...	0.78	0.74	0.82	73	46271	22	3	13	6	26
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.66	0.67	0.65	58	37586	31	6	25	0	29
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.59	0.60	0.58	53	36765	44	5	33	6	35
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.68	0.68	0.68	60	36768	30	3	25	2	28
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.61	0.63	0.60	56	36222	41	5	32	4	33
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.57	0.56	0.57	49	36499	39	5	32	2	38
SRP_00050	Metazoa_SRP links to Rfam database...	0.84	0.80	0.88	79	44760	11	0	11	0	20
SRP_00066	Metazoa_SRP links to Rfam database...	0.06	0.06	0.06	6	45357	88	10	78	0	94
SRP_00086	Metazoa_SRP links to Rfam database...	0.76	0.75	0.77	75	44155	25	2	21	2	25
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.65	0.65	0.64	58	34101	32	4	28	0	31
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.64	0.63	0.66	57	35691	30	3	27	0	33
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.64	0.62	0.66	56	35426	32	5	24	3	34
SRP_00102	Metazoa_SRP links to Rfam database...	0.61	0.59	0.64	60	44457	34	4	30	0	41
SRP_00103	Metazoa_SRP links to Rfam database...	0.15	0.15	0.16	15	45355	81	6	75	0	87
SRP_00152	Plant_SRP links to Rfam database...	0.36	0.35	0.38	36	45658	60	5	54	1	67
SRP_00171	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45358	93	15	78	0	88
SRP_00178	Plant_SRP links to Rfam database...	0.74	0.71	0.78	72	45661	23	2	18	3	30
SRP_00179	Plant_SRP links to Rfam database...	0.79	0.75	0.84	79	45962	19	1	14	4	26
SRP_00181	Plant_SRP links to Rfam database...	0.27	0.25	0.30	26	45968	62	2	60	0	76
SRP_00182	Plant_SRP links to Rfam database...	0.59	0.56	0.61	57	45963	37	5	31	1	44
SRP_00188	Plant_SRP links to Rfam database...	0.20	0.20	0.21	16	31048	61	8	53	0	63
SRP_00228	Metazoa_SRP links to Rfam database...	0.81	0.79	0.82	75	45360	23	0	16	7	20
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.66	0.64	0.68	55	36234	33	2	24	7	31
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.57	0.56	0.58	49	36231	37	3	32	2	39
SRP_00317	Metazoa_SRP links to Rfam database...	0.78	0.74	0.82	73	45061	19	1	15	3	25
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.31	0.44	0.22	17	35167	73	31	30	12	22
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.69	0.66	0.71	60	35427	26	1	23	2	31
SRP_00347	Metazoa_SRP links to Rfam database...	0.67	0.66	0.68	63	46572	35	5	25	5	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.83	0.81	0.85	79	43863	17	1	13	3	19
TMR_00017	tmRNA links to Rfam database...	0.22	0.22	0.22	22	67063	80	10	66	4	80
TMR_00018	tmRNA links to Rfam database...	0.23	0.24	0.23	22	64523	79	15	60	4	70
TMR_00042	tmRNA links to Rfam database...	0.18	0.17	0.18	17	62741	80	9	68	3	81
TMR_00046	tmRNA links to Rfam database...	0.17	0.18	0.17	17	62734	85	11	73	1	79
TMR_00048	tmRNA links to Rfam database...	0.11	0.12	0.10	11	64874	99	16	79	4	84
TMR_00080	tmRNA links to Rfam database...	0.25	0.26	0.24	25	70396	79	25	54	0	71
TMR_00082	tmRNA links to Rfam database...	0.59	0.58	0.60	56	67802	43	12	26	5	40
TMR_00123	tmRNA links to Rfam database...	0.05	0.05	0.05	5	66332	97	16	77	4	96
TMR_00137	tmRNA links to Rfam database...	0.13	0.13	0.13	12	60979	88	20	64	4	77
TMR_00142	tmRNA links to Rfam database...	0.20	0.21	0.19	21	70764	98	14	77	7	81
TMR_00207	tmRNA links to Rfam database...	0.28	0.28	0.28	29	72287	79	12	62	5	74
TMR_00257	tmRNA links to Rfam database...	0.05	0.05	0.05	5	67067	93	9	80	4	93
TMR_00271	tmRNA links to Rfam database...	0.29	0.29	0.29	26	64172	67	12	51	4	65
TMR_00332	tmRNA links to Rfam database...	0.32	0.31	0.32	31	67065	67	7	58	2	68
TMR_00378	tmRNA links to Rfam database...	0.17	0.18	0.17	17	67797	93	8	74	11	80
TMR_00404	tmRNA links to Rfam database...	0.38	0.39	0.37	36	67431	75	11	50	14	56
TMR_00427	tmRNA links to Rfam database...	0.38	0.38	0.38	37	67431	65	13	47	5	60
TMR_00443	tmRNA links to Rfam database...	0.25	0.24	0.27	25	67068	75	11	57	7	79
TMR_00451	tmRNA links to Rfam database...	0.10	0.11	0.10	10	63444	92	18	74	0	79
TMR_00458	tmRNA links to Rfam database...	0.00	0.00	0.00	0	63450	104	13	83	8	93
TMR_00469	tmRNA links to Rfam database...	0.38	0.39	0.37	39	64514	71	18	49	4	61
TMR_00472	tmRNA links to Rfam database...	0.18	0.20	0.17	19	64510	95	14	77	4	78
TMR_00519	tmRNA links to Rfam database...	0.17	0.18	0.17	17	63088	95	18	67	10	78
TMR_00520	tmRNA links to Rfam database...	0.22	0.21	0.24	21	63101	78	8	60	10	78
TMR_00522	tmRNA links to Rfam database...	0.42	0.41	0.42	40	63095	64	8	47	9	57
TMR_00528	tmRNA links to Rfam database...	0.33	0.32	0.33	31	63097	72	14	48	10	66
TMR_00540	tmRNA links to Rfam database...	0.32	0.32	0.33	33	73435	74	4	64	6	71
TMR_00568	tmRNA links to Rfam database...	0.41	0.39	0.42	39	60634	59	7	46	6	60
TMR_00571	tmRNA links to Rfam database...	0.22	0.22	0.22	22	60624	87	13	67	7	77
TMR_00580	tmRNA links to Rfam database...	0.27	0.26	0.29	26	60635	70	14	51	5	74
TMR_00584	tmRNA links to Rfam database...	0.38	0.40	0.37	39	60969	74	8	59	7	58
TMR_00586	tmRNA links to Rfam database...	0.38	0.38	0.37	37	60976	69	12	50	7	60
TMR_00616	tmRNA links to Rfam database...	0.45	0.44	0.46	44	67065	58	11	41	6	55
TMR_00699	tmRNA links to Rfam database...	0.27	0.25	0.30	26	67073	66	7	55	4	76
TMR_00702	tmRNA links to Rfam database...	0.26	0.26	0.27	26	67063	77	11	61	5	74
TMR_00703	tmRNA links to Rfam database...	0.29	0.28	0.31	28	67437	67	14	49	4	71

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]

Performance of RNAshapes - scored lower in this pairwise comparison

1. Total counts & total scores for RNAshapes

2. Individual counts for RNAshapes [ download as .csv ]