CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASampler(20)		RNAsubopt
MCC	0.565	>	0.461
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043	>	0.462 ± 0.058
Sensitivity	0.413	<	0.471
Positive Predictive Value	0.772	>	0.454
Total TP	3079	<	3505
Total TN	4282091	>	4278360
Total FP	1146	<	4645
Total FP CONTRA	258	<	732
Total FP INCONS	649	<	3480
Total FP COMP	239	<	433
Total FN	4370	>	3944
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASampler(20) and RNAsubopt. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and RNAsubopt).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and RNAsubopt).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and RNAsubopt. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and RNAsubopt).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	3079
Total TN	4282091
Total FP	1146
Total FP CONTRA	258
Total FP INCONS	649
Total FP COMP	239
Total FN	4370

Total Scores
MCC	0.565
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043
Sensitivity	0.413
Positive Predictive Value	0.772
Nr of predictions	78

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Performance of RNAsubopt - scored lower in this pairwise comparison

1. Total counts & total scores for RNAsubopt

Total Base Pair Counts
Total TP	3505
Total TN	4278360
Total FP	4645
Total FP CONTRA	732
Total FP INCONS	3480
Total FP COMP	433
Total FN	3944

Total Scores
MCC	0.461
Average MCC ± 95% Confidence Intervals	0.462 ± 0.058
Sensitivity	0.471
Positive Predictive Value	0.454
Nr of predictions	78

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2. Individual counts for RNAsubopt [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.36	0.38	0.35	34	45353	68	8	56	4	55
ASE_00090	RNaseP_bact_a links to Rfam database...	0.53	0.54	0.51	55	55503	57	4	49	4	46
ASE_00135	RNaseP_bact_a links to Rfam database...	0.45	0.45	0.45	49	63081	66	9	51	6	60
ASE_00153	RNaseP_nuc links to Rfam database...	0.67	0.68	0.66	50	57554	66	2	24	40	23
ASE_00215	RNaseP_bact_a links to Rfam database...	0.40	0.38	0.42	38	48425	53	2	51	0	61
ASE_00305	RNaseP_bact_b links to Rfam database...	0.57	0.61	0.53	52	54516	55	17	30	8	33
ASE_00328	RNaseP_bact_b links to Rfam database...	0.41	0.41	0.41	46	72659	75	5	61	9	66
ASE_00361	RNaseP_bact_a links to Rfam database...	0.33	0.32	0.34	41	75346	82	10	69	3	86
ASE_00427	RNaseP_nuc links to Rfam database...	0.14	0.20	0.10	9	40668	82	27	51	4	37
ASE_00441	RNaseP_bact_a links to Rfam database...	0.77	0.74	0.81	83	64158	33	4	16	13	29
SRP_00006	Metazoa_SRP links to Rfam database...	0.93	0.91	0.96	92	45657	13	0	4	9	9
SRP_00011	Plant_SRP links to Rfam database...	0.50	0.49	0.52	51	46262	47	3	44	0	53
SRP_00015	Plant_SRP links to Rfam database...	0.77	0.74	0.80	73	46269	23	0	18	5	26
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.67	0.68	0.66	59	37585	32	5	26	1	28
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.62	0.61	0.63	54	36770	40	2	30	8	34
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.77	0.78	0.76	69	36765	24	4	18	2	19
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.66	0.66	0.66	59	36225	36	2	29	5	30
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.12	0.13	0.13	11	36497	77	6	71	0	76
SRP_00050	Metazoa_SRP links to Rfam database...	0.97	0.95	0.99	94	44755	4	0	1	3	5
SRP_00066	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45355	96	10	86	0	100
SRP_00086	Metazoa_SRP links to Rfam database...	0.95	0.94	0.96	94	44155	8	0	4	4	6
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.66	0.67	0.64	60	34097	34	5	29	0	29
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.86	0.86	0.88	77	35690	11	1	10	0	13
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.63	0.63	0.62	57	35419	37	5	30	2	33
SRP_00102	Metazoa_SRP links to Rfam database...	0.87	0.86	0.88	87	44452	14	1	11	2	14
SRP_00103	Metazoa_SRP links to Rfam database...	0.86	0.85	0.86	87	45350	14	0	14	0	15
SRP_00152	Plant_SRP links to Rfam database...	0.55	0.55	0.55	57	45650	49	5	41	3	46
SRP_00171	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45348	103	15	88	0	88
SRP_00178	Plant_SRP links to Rfam database...	0.85	0.80	0.90	82	45662	12	1	8	3	20
SRP_00179	Plant_SRP links to Rfam database...	0.70	0.68	0.72	71	45958	31	5	22	4	34
SRP_00181	Plant_SRP links to Rfam database...	0.20	0.20	0.20	20	45956	80	1	79	0	82
SRP_00182	Plant_SRP links to Rfam database...	0.70	0.68	0.71	69	45959	31	2	26	3	32
SRP_00188	Plant_SRP links to Rfam database...	0.19	0.19	0.19	15	31046	64	9	55	0	64
SRP_00228	Metazoa_SRP links to Rfam database...	0.95	0.94	0.97	89	45359	12	0	3	9	6
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.34	0.36	0.33	31	36221	65	7	56	2	55
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.06	0.07	0.06	6	36221	88	12	76	0	82
SRP_00317	Metazoa_SRP links to Rfam database...	0.93	0.89	0.98	87	45061	10	0	2	8	11
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.30	0.41	0.22	16	35173	77	26	30	21	23
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.65	0.64	0.67	58	35424	31	1	28	2	33
SRP_00347	Metazoa_SRP links to Rfam database...	0.85	0.84	0.86	81	46571	19	4	9	6	15
SRP_00368	Metazoa_SRP links to Rfam database...	0.95	0.94	0.97	92	43861	9	0	3	6	6
TMR_00017	tmRNA links to Rfam database...	0.36	0.38	0.35	39	67049	79	17	56	6	63
TMR_00018	tmRNA links to Rfam database...	0.12	0.13	0.12	12	64521	93	11	76	6	80
TMR_00042	tmRNA links to Rfam database...	0.24	0.24	0.24	24	62735	79	9	67	3	74
TMR_00046	tmRNA links to Rfam database...	0.54	0.55	0.52	53	62734	54	12	36	6	43
TMR_00048	tmRNA links to Rfam database...	0.22	0.24	0.20	23	64866	96	16	75	5	72
TMR_00080	tmRNA links to Rfam database...	0.33	0.33	0.32	32	70401	67	19	48	0	64
TMR_00082	tmRNA links to Rfam database...	0.41	0.42	0.40	40	67795	65	19	42	4	56
TMR_00123	tmRNA links to Rfam database...	0.46	0.47	0.46	47	66327	57	11	45	1	54
TMR_00137	tmRNA links to Rfam database...	0.16	0.18	0.15	16	60971	92	19	69	4	73
TMR_00142	tmRNA links to Rfam database...	0.50	0.52	0.49	53	70767	66	16	40	10	49
TMR_00207	tmRNA links to Rfam database...	0.40	0.41	0.40	42	72286	69	9	53	7	61
TMR_00257	tmRNA links to Rfam database...	0.12	0.12	0.13	12	67066	89	7	76	6	86
TMR_00271	tmRNA links to Rfam database...	0.38	0.40	0.37	36	64163	71	13	49	9	55
TMR_00332	tmRNA links to Rfam database...	0.48	0.47	0.49	47	67065	53	12	37	4	52
TMR_00366	tmRNA links to Rfam database...	0.27	0.28	0.27	28	67791	90	16	61	13	72
TMR_00378	tmRNA links to Rfam database...	0.13	0.14	0.13	14	67784	109	18	80	11	83
TMR_00404	tmRNA links to Rfam database...	0.29	0.32	0.27	29	67420	90	24	55	11	63
TMR_00427	tmRNA links to Rfam database...	0.31	0.31	0.31	30	67431	74	9	58	7	67
TMR_00443	tmRNA links to Rfam database...	0.45	0.45	0.45	47	67056	60	15	43	2	57
TMR_00451	tmRNA links to Rfam database...	0.17	0.19	0.16	17	63441	88	16	72	0	72
TMR_00458	tmRNA links to Rfam database...	0.36	0.37	0.37	34	63453	68	11	48	9	59
TMR_00469	tmRNA links to Rfam database...	0.48	0.51	0.46	51	64508	66	21	40	5	49
TMR_00472	tmRNA links to Rfam database...	0.59	0.58	0.60	56	64526	52	7	31	14	41
TMR_00519	tmRNA links to Rfam database...	0.20	0.21	0.19	20	63083	97	18	69	10	75
TMR_00520	tmRNA links to Rfam database...	0.33	0.35	0.32	35	63080	85	13	62	10	64
TMR_00522	tmRNA links to Rfam database...	0.46	0.47	0.45	46	63088	65	12	44	9	51
TMR_00528	tmRNA links to Rfam database...	0.34	0.34	0.34	33	63093	75	13	51	11	64
TMR_00540	tmRNA links to Rfam database...	0.24	0.24	0.24	25	73433	82	12	66	4	79
TMR_00568	tmRNA links to Rfam database...	0.26	0.27	0.25	27	60617	88	12	70	6	72
TMR_00571	tmRNA links to Rfam database...	0.28	0.29	0.28	29	60621	84	12	64	8	70
TMR_00580	tmRNA links to Rfam database...	0.31	0.31	0.30	31	60624	78	15	56	7	69
TMR_00584	tmRNA links to Rfam database...	0.40	0.42	0.38	41	60966	74	9	59	6	56
TMR_00586	tmRNA links to Rfam database...	0.36	0.37	0.35	36	60972	68	12	55	1	61
TMR_00616	tmRNA links to Rfam database...	0.26	0.27	0.25	27	67055	83	21	58	4	72
TMR_00699	tmRNA links to Rfam database...	0.33	0.34	0.32	35	67053	77	12	61	4	67
TMR_00702	tmRNA links to Rfam database...	0.56	0.57	0.55	57	67057	52	15	32	5	43
TMR_00703	tmRNA links to Rfam database...	0.26	0.26	0.25	26	67426	82	9	67	6	73

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]

Performance of RNAsubopt - scored lower in this pairwise comparison

1. Total counts & total scores for RNAsubopt

2. Individual counts for RNAsubopt [ download as .csv ]