CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASampler(20)		RSpredict(seed)
MCC	0.578	>	0.011
Average MCC ± 95% Confidence Intervals	0.525 ± 0.079	>	0.013 ± 0.010
Sensitivity	0.384	>	0.010
Positive Predictive Value	0.871	>	0.016
Total TP	1475	>	39
Total TN	1860227	>	1859459
Total FP	283	<	2455
Total FP CONTRA	28	<	307
Total FP INCONS	190	<	2115
Total FP COMP	65	>	33
Total FN	2363	<	3799
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASampler(20) and RSpredict(seed). Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(seed)).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(seed)).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and RSpredict(seed). The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and RSpredict(seed)).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	1475
Total TN	1860227
Total FP	283
Total FP CONTRA	28
Total FP INCONS	190
Total FP COMP	65
Total FN	2363

Total Scores
MCC	0.578
Average MCC ± 95% Confidence Intervals	0.525 ± 0.079
Sensitivity	0.384
Positive Predictive Value	0.871
Nr of predictions	41

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40

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Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

Total Base Pair Counts
Total TP	39
Total TN	1859459
Total FP	2455
Total FP CONTRA	307
Total FP INCONS	2115
Total FP COMP	33
Total FN	3799

Total Scores
MCC	0.011
Average MCC ± 95% Confidence Intervals	0.013 ± 0.010
Sensitivity	0.010
Positive Predictive Value	0.016
Nr of predictions	41

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2. Individual counts for RSpredict(seed) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.09	0.04	0.17	4	45428	21	0	19	2	85
ASE_00090	RNaseP_bact_a links to Rfam database...	0.08	0.04	0.16	4	55586	26	0	21	5	97
ASE_00135	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	63169	21	0	21	0	109
ASE_00153	RNaseP_nuc links to Rfam database...	0.00	0.00	0.00	0	57617	13	2	11	0	73
ASE_00215	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	48497	24	0	19	5	99
ASE_00305	RNaseP_bact_b links to Rfam database...	0.00	0.00	0.00	0	54563	57	10	42	5	85
ASE_00328	RNaseP_bact_b links to Rfam database...	0.00	0.00	0.00	0	72715	59	11	45	3	112
ASE_00361	RNaseP_bact_a links to Rfam database...	0.00	0.00	0.00	0	75427	39	1	38	0	127
ASE_00427	RNaseP_nuc links to Rfam database...	0.00	0.00	0.00	0	40744	11	5	6	0	46
ASE_00441	RNaseP_bact_a links to Rfam database...	0.07	0.03	0.17	3	64243	17	0	15	2	109
SRP_00006	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45687	66	8	58	0	101
SRP_00011	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	46290	70	5	65	0	104
SRP_00015	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	46288	72	10	62	0	99
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	37604	71	8	63	0	87
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36787	69	10	59	0	88
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36787	69	10	59	0	88
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36246	69	9	60	0	89
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36515	70	10	60	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	44771	79	5	74	0	99
SRP_00066	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45372	79	9	70	0	100
SRP_00086	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	44175	78	6	72	0	100
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.05	0.04	0.06	4	34125	62	8	54	0	85
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35709	69	9	60	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.08	0.07	0.09	6	35444	61	6	55	0	84
SRP_00102	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	44473	78	5	73	0	101
SRP_00103	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45372	79	7	72	0	102
SRP_00152	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	45682	71	8	63	0	103
SRP_00171	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45381	70	13	57	0	88
SRP_00178	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	45685	68	8	60	0	102
SRP_00179	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	45986	70	10	60	0	105
SRP_00181	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	45986	70	11	59	0	102
SRP_00182	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	45987	69	10	59	0	101
SRP_00188	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	31055	70	13	57	0	79
SRP_00228	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45385	66	6	60	0	95
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.08	0.07	0.09	6	36246	63	6	57	0	80
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.08	0.07	0.09	6	36247	62	14	48	0	82
SRP_00317	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45079	71	8	63	0	98
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35188	68	25	32	11	39
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.08	0.07	0.09	6	35445	60	6	54	0	85
SRP_00347	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	46596	69	9	60	0	96
SRP_00368	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	43877	79	6	73	0	98

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]

Performance of RSpredict(seed) - scored lower in this pairwise comparison

1. Total counts & total scores for RSpredict(seed)

2. Individual counts for RSpredict(seed) [ download as .csv ]