CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASampler(20)		Vsfold4
MCC	0.565	>	0.195
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043	>	0.189 ± 0.029
Sensitivity	0.413	>	0.181
Positive Predictive Value	0.772	>	0.213
Total TP	3079	>	1347
Total TN	4282091	>	4279751
Total FP	1146	<	5264
Total FP CONTRA	258	<	644
Total FP INCONS	649	<	4335
Total FP COMP	239	<	285
Total FN	4370	<	6102
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASampler(20) and Vsfold4. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Vsfold4).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and Vsfold4).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Vsfold4. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Vsfold4).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	3079
Total TN	4282091
Total FP	1146
Total FP CONTRA	258
Total FP INCONS	649
Total FP COMP	239
Total FN	4370

Total Scores
MCC	0.565
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043
Sensitivity	0.413
Positive Predictive Value	0.772
Nr of predictions	78

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

Total Base Pair Counts
Total TP	1347
Total TN	4279751
Total FP	5264
Total FP CONTRA	644
Total FP INCONS	4335
Total FP COMP	285
Total FN	6102

Total Scores
MCC	0.195
Average MCC ± 95% Confidence Intervals	0.189 ± 0.029
Sensitivity	0.181
Positive Predictive Value	0.213
Nr of predictions	78

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2. Individual counts for Vsfold4 [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.47	0.42	0.54	37	45382	38	0	32	6	52
ASE_00090	RNaseP_bact_a links to Rfam database...	0.48	0.46	0.51	46	55521	46	4	40	2	55
ASE_00135	RNaseP_bact_a links to Rfam database...	0.38	0.35	0.42	38	63100	57	8	44	5	71
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.37	0.39	27	57561	65	9	33	23	46
ASE_00215	RNaseP_bact_a links to Rfam database...	0.47	0.41	0.53	41	48438	38	7	30	1	58
ASE_00305	RNaseP_bact_b links to Rfam database...	0.49	0.47	0.51	40	54537	42	6	32	4	45
ASE_00328	RNaseP_bact_b links to Rfam database...	0.43	0.39	0.48	44	72679	54	4	44	6	68
ASE_00361	RNaseP_bact_a links to Rfam database...	0.37	0.32	0.43	41	75371	54	2	52	0	86
ASE_00427	RNaseP_nuc links to Rfam database...	0.00	0.00	0.00	0	40700	67	10	45	12	46
ASE_00441	RNaseP_bact_a links to Rfam database...	0.36	0.32	0.41	36	64173	52	0	52	0	76
SRP_00006	Metazoa_SRP links to Rfam database...	0.22	0.20	0.25	20	45674	61	2	57	2	81
SRP_00011	Plant_SRP links to Rfam database...	0.15	0.13	0.17	14	46277	69	9	60	0	90
SRP_00015	Plant_SRP links to Rfam database...	0.19	0.17	0.22	17	46281	62	6	56	0	82
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	37601	74	12	62	0	87
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.06	0.06	0.07	5	36785	66	9	57	0	83
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36786	71	5	65	1	88
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36250	65	8	57	0	89
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36512	73	4	69	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.12	0.10	0.14	10	44776	66	4	60	2	89
SRP_00066	Metazoa_SRP links to Rfam database...	0.09	0.08	0.10	8	45373	70	6	64	0	92
SRP_00086	Metazoa_SRP links to Rfam database...	0.20	0.18	0.23	18	44176	61	4	55	2	82
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	34128	63	4	59	0	89
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.19	0.18	0.22	16	35704	58	1	57	0	74
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.12	0.11	0.14	10	35438	63	0	63	0	80
SRP_00102	Metazoa_SRP links to Rfam database...	0.11	0.10	0.13	10	44471	70	2	68	0	91
SRP_00103	Metazoa_SRP links to Rfam database...	0.18	0.17	0.19	17	45362	72	2	70	0	85
SRP_00152	Plant_SRP links to Rfam database...	0.14	0.13	0.17	13	45676	64	11	53	0	90
SRP_00171	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45373	78	11	67	0	88
SRP_00178	Plant_SRP links to Rfam database...	0.08	0.07	0.09	7	45673	73	8	65	0	95
SRP_00179	Plant_SRP links to Rfam database...	0.12	0.10	0.14	11	45977	68	9	59	0	94
SRP_00181	Plant_SRP links to Rfam database...	0.18	0.17	0.20	17	45972	67	9	58	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.34	0.32	0.36	32	45968	56	10	46	0	69
SRP_00188	Plant_SRP links to Rfam database...	0.13	0.13	0.14	10	31055	60	6	54	0	69
SRP_00228	Metazoa_SRP links to Rfam database...	0.10	0.09	0.12	9	45374	70	6	62	2	86
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.07	0.07	0.08	6	36239	71	5	65	1	80
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.13	0.11	0.14	10	36245	60	12	48	0	78
SRP_00317	Metazoa_SRP links to Rfam database...	0.10	0.09	0.11	9	45069	74	2	70	2	89
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35174	75	34	37	4	39
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.07	0.07	0.08	6	35435	70	3	67	0	85
SRP_00347	Metazoa_SRP links to Rfam database...	0.08	0.07	0.09	7	46591	67	8	59	0	89
SRP_00368	Metazoa_SRP links to Rfam database...	0.10	0.09	0.12	9	43879	70	4	64	2	89
TMR_00017	tmRNA links to Rfam database...	0.33	0.29	0.37	30	67080	55	4	47	4	72
TMR_00018	tmRNA links to Rfam database...	0.24	0.23	0.25	21	64536	67	11	52	4	71
TMR_00042	tmRNA links to Rfam database...	0.20	0.18	0.22	18	62753	67	12	52	3	80
TMR_00046	tmRNA links to Rfam database...	0.25	0.25	0.26	24	62741	75	15	55	5	72
TMR_00048	tmRNA links to Rfam database...	0.23	0.22	0.24	21	64894	71	14	51	6	74
TMR_00080	tmRNA links to Rfam database...	0.14	0.14	0.14	13	70410	79	15	62	2	83
TMR_00082	tmRNA links to Rfam database...	0.24	0.23	0.26	22	67811	65	9	54	2	74
TMR_00123	tmRNA links to Rfam database...	0.35	0.33	0.38	33	66344	58	7	46	5	68
TMR_00137	tmRNA links to Rfam database...	0.08	0.08	0.09	7	60996	81	8	64	9	82
TMR_00142	tmRNA links to Rfam database...	0.09	0.09	0.10	9	70782	92	13	72	7	93
TMR_00207	tmRNA links to Rfam database...	0.17	0.17	0.18	17	72293	85	16	64	5	86
TMR_00257	tmRNA links to Rfam database...	0.10	0.09	0.11	9	67077	79	7	68	4	89
TMR_00271	tmRNA links to Rfam database...	0.21	0.19	0.23	17	64188	64	6	50	8	74
TMR_00332	tmRNA links to Rfam database...	0.19	0.17	0.21	17	67081	68	7	56	5	82
TMR_00366	tmRNA links to Rfam database...	0.17	0.16	0.18	16	67807	79	13	60	6	84
TMR_00378	tmRNA links to Rfam database...	0.20	0.20	0.20	19	67800	82	13	64	5	78
TMR_00404	tmRNA links to Rfam database...	0.28	0.28	0.27	26	67433	70	22	47	1	66
TMR_00427	tmRNA links to Rfam database...	0.12	0.11	0.13	11	67445	79	8	64	7	86
TMR_00443	tmRNA links to Rfam database...	0.17	0.14	0.20	15	67085	65	3	58	4	89
TMR_00451	tmRNA links to Rfam database...	0.17	0.16	0.18	14	63470	66	13	49	4	75
TMR_00458	tmRNA links to Rfam database...	0.16	0.15	0.17	14	63464	78	9	59	10	79
TMR_00469	tmRNA links to Rfam database...	0.34	0.33	0.34	33	64524	70	11	52	7	67
TMR_00472	tmRNA links to Rfam database...	0.35	0.35	0.35	34	64524	68	12	50	6	63
TMR_00519	tmRNA links to Rfam database...	0.23	0.22	0.25	21	63105	74	12	52	10	74
TMR_00520	tmRNA links to Rfam database...	0.23	0.21	0.24	21	63103	71	13	53	5	78
TMR_00522	tmRNA links to Rfam database...	0.12	0.11	0.14	11	63109	79	11	59	9	86
TMR_00528	tmRNA links to Rfam database...	0.08	0.07	0.09	7	63109	83	16	58	9	90
TMR_00540	tmRNA links to Rfam database...	0.09	0.09	0.10	9	73449	89	6	72	11	95
TMR_00568	tmRNA links to Rfam database...	0.14	0.13	0.16	13	60644	75	6	63	6	86
TMR_00571	tmRNA links to Rfam database...	0.19	0.18	0.20	18	60637	72	7	64	1	81
TMR_00580	tmRNA links to Rfam database...	0.28	0.27	0.30	27	60635	65	9	55	1	73
TMR_00584	tmRNA links to Rfam database...	0.37	0.34	0.40	33	60993	56	8	41	7	64
TMR_00586	tmRNA links to Rfam database...	0.25	0.23	0.27	22	60993	66	7	53	6	75
TMR_00616	tmRNA links to Rfam database...	0.28	0.26	0.30	26	67075	66	9	51	6	73
TMR_00699	tmRNA links to Rfam database...	0.15	0.14	0.17	14	67078	73	14	55	4	88
TMR_00702	tmRNA links to Rfam database...	0.17	0.15	0.19	15	67081	72	7	58	7	85
TMR_00703	tmRNA links to Rfam database...	0.32	0.29	0.35	29	67446	60	5	48	7	70

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]

Performance of Vsfold4 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold4

2. Individual counts for Vsfold4 [ download as .csv ]