CompaRNA - on-line benchmarks of RNA structure prediction methods

Laboratory of Structural Bioinformatics @ Adam Mickiewicz University in Poznan

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Overview

Metric	RNASampler(20)		Vsfold5
MCC	0.565	>	0.188
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043	>	0.177 ± 0.030
Sensitivity	0.413	>	0.178
Positive Predictive Value	0.772	>	0.201
Total TP	3079	>	1326
Total TN	4282091	>	4279490
Total FP	1146	<	5547
Total FP CONTRA	258	<	682
Total FP INCONS	649	<	4579
Total FP COMP	239	<	286
Total FN	4370	<	6123
P-value	3.56938820447e-08

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Performance plots

Comparison of performance of RNASampler(20) and Vsfold5. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(20) and Vsfold5).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(20) and Vsfold5).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(20) and Vsfold5. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(20) and Vsfold5).

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Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

Total Base Pair Counts
Total TP	3079
Total TN	4282091
Total FP	1146
Total FP CONTRA	258
Total FP INCONS	649
Total FP COMP	239
Total FN	4370

Total Scores
MCC	0.565
Average MCC ± 95% Confidence Intervals	0.539 ± 0.043
Sensitivity	0.413
Positive Predictive Value	0.772
Nr of predictions	78

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2. Individual counts for RNASampler(20) [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.44	0.34	0.58	30	45399	23	1	21	1	59
ASE_00090	RNaseP_bact_a links to Rfam database...	0.54	0.40	0.74	40	55557	14	0	14	0	61
ASE_00135	RNaseP_bact_a links to Rfam database...	0.54	0.36	0.83	39	63143	16	0	8	8	70
ASE_00153	RNaseP_nuc links to Rfam database...	0.38	0.33	0.44	24	57576	38	7	23	8	49
ASE_00215	RNaseP_bact_a links to Rfam database...	0.38	0.23	0.62	23	48479	16	0	14	2	76
ASE_00305	RNaseP_bact_b links to Rfam database...	0.78	0.71	0.86	60	54545	14	1	9	4	25
ASE_00328	RNaseP_bact_b links to Rfam database...	0.70	0.57	0.85	64	72696	14	5	6	3	48
ASE_00361	RNaseP_bact_a links to Rfam database...	0.34	0.21	0.55	27	75417	26	3	19	4	100
ASE_00427	RNaseP_nuc links to Rfam database...	0.57	0.46	0.72	21	40726	18	1	7	10	25
ASE_00441	RNaseP_bact_a links to Rfam database...	0.46	0.31	0.69	35	64210	16	0	16	0	77
SRP_00006	Metazoa_SRP links to Rfam database...	0.87	0.76	0.99	77	45675	4	0	1	3	24
SRP_00011	Plant_SRP links to Rfam database...	0.55	0.42	0.71	44	46298	18	4	14	0	60
SRP_00015	Plant_SRP links to Rfam database...	0.74	0.59	0.94	58	46298	5	3	1	1	41
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	37668	0	0	0	0	80
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.51	0.27	0.96	24	36831	1	0	1	0	64
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36849	0	0	0	0	81
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.35	0.12	1.00	11	36304	0	0	0	0	78
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36585	0	0	0	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.86	0.76	0.99	75	44774	3	0	1	2	24
SRP_00066	Metazoa_SRP links to Rfam database...	0.81	0.66	0.99	66	45384	1	0	1	0	34
SRP_00086	Metazoa_SRP links to Rfam database...	0.87	0.77	0.99	77	44175	3	0	1	2	23
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.40	0.16	1.00	14	34177	0	0	0	0	75
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35778	0	0	0	0	90
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35511	0	0	0	0	90
SRP_00102	Metazoa_SRP links to Rfam database...	0.86	0.77	0.95	78	44469	4	0	4	0	23
SRP_00103	Metazoa_SRP links to Rfam database...	0.80	0.64	1.00	65	45386	0	0	0	0	37
SRP_00152	Plant_SRP links to Rfam database...	0.52	0.27	1.00	28	45725	0	0	0	0	75
SRP_00171	Metazoa_SRP links to Rfam database...	0.74	0.61	0.89	54	45390	7	2	5	0	34
SRP_00178	Plant_SRP links to Rfam database...	0.36	0.13	1.00	13	45740	0	0	0	0	89
SRP_00179	Plant_SRP links to Rfam database...	0.39	0.16	0.94	17	46038	1	0	1	0	88
SRP_00181	Plant_SRP links to Rfam database...	0.41	0.17	1.00	17	46039	0	0	0	0	85
SRP_00182	Plant_SRP links to Rfam database...	0.78	0.66	0.92	67	45983	6	0	6	0	34
SRP_00188	Plant_SRP links to Rfam database...	0.26	0.14	0.48	11	31102	12	1	11	0	68
SRP_00228	Metazoa_SRP links to Rfam database...	0.88	0.78	0.99	74	45376	7	0	1	6	21
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.47	0.23	0.95	20	36294	1	0	1	0	66
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.28	0.08	1.00	7	36308	0	0	0	0	81
SRP_00317	Metazoa_SRP links to Rfam database...	0.76	0.61	0.95	60	45087	8	0	3	5	38
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.42	0.18	1.00	7	35238	0	0	0	0	32
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.38	0.14	1.00	13	35498	0	0	0	0	78
SRP_00347	Metazoa_SRP links to Rfam database...	0.80	0.66	0.98	63	46601	5	0	1	4	33
SRP_00368	Metazoa_SRP links to Rfam database...	0.77	0.59	1.00	58	43898	2	0	0	2	40
TMR_00017	tmRNA links to Rfam database...	0.60	0.45	0.81	46	67104	15	2	9	4	56
TMR_00018	tmRNA links to Rfam database...	0.52	0.41	0.64	38	64561	25	10	11	4	54
TMR_00042	tmRNA links to Rfam database...	0.60	0.42	0.85	41	62787	13	0	7	6	57
TMR_00046	tmRNA links to Rfam database...	0.48	0.40	0.58	38	62769	34	5	23	6	58
TMR_00048	tmRNA links to Rfam database...	0.61	0.46	0.80	44	64925	16	3	8	5	51
TMR_00080	tmRNA links to Rfam database...	0.49	0.41	0.60	39	70435	28	10	16	2	57
TMR_00082	tmRNA links to Rfam database...	0.43	0.31	0.59	30	67845	21	13	8	0	66
TMR_00123	tmRNA links to Rfam database...	0.60	0.46	0.79	46	66372	17	3	9	5	55
TMR_00137	tmRNA links to Rfam database...	0.47	0.37	0.59	33	61019	28	11	12	5	56
TMR_00142	tmRNA links to Rfam database...	0.56	0.47	0.67	48	70804	31	9	15	7	54
TMR_00207	tmRNA links to Rfam database...	0.52	0.39	0.70	40	72333	21	4	13	4	63
TMR_00257	tmRNA links to Rfam database...	0.56	0.40	0.78	39	67111	16	3	8	5	59
TMR_00271	tmRNA links to Rfam database...	0.48	0.34	0.69	31	64216	21	7	7	7	60
TMR_00332	tmRNA links to Rfam database...	0.52	0.41	0.66	41	67099	22	6	15	1	58
TMR_00366	tmRNA links to Rfam database...	0.55	0.46	0.65	46	67825	36	12	13	11	54
TMR_00378	tmRNA links to Rfam database...	0.55	0.46	0.65	45	67827	35	8	16	11	52
TMR_00404	tmRNA links to Rfam database...	0.66	0.54	0.81	50	67466	20	4	8	8	42
TMR_00427	tmRNA links to Rfam database...	0.47	0.34	0.65	33	67477	20	7	11	2	64
TMR_00443	tmRNA links to Rfam database...	0.56	0.41	0.75	43	67104	14	6	8	0	61
TMR_00451	tmRNA links to Rfam database...	0.34	0.25	0.47	22	63499	29	10	15	4	67
TMR_00458	tmRNA links to Rfam database...	0.55	0.42	0.72	39	63492	15	7	8	0	54
TMR_00469	tmRNA links to Rfam database...	0.72	0.61	0.86	61	64549	11	4	6	1	39
TMR_00472	tmRNA links to Rfam database...	0.75	0.63	0.88	61	64551	13	2	6	5	36
TMR_00519	tmRNA links to Rfam database...	0.50	0.40	0.62	38	63129	27	14	9	4	57
TMR_00520	tmRNA links to Rfam database...	0.40	0.31	0.52	31	63130	33	12	17	4	68
TMR_00522	tmRNA links to Rfam database...	0.54	0.42	0.68	41	63130	24	9	10	5	56
TMR_00528	tmRNA links to Rfam database...	0.49	0.40	0.59	39	63124	31	12	15	4	58
TMR_00540	tmRNA links to Rfam database...	0.47	0.37	0.59	38	73472	26	10	16	0	66
TMR_00568	tmRNA links to Rfam database...	0.72	0.66	0.78	65	60643	26	2	16	8	34
TMR_00571	tmRNA links to Rfam database...	0.77	0.71	0.83	70	60642	22	2	12	8	29
TMR_00580	tmRNA links to Rfam database...	0.53	0.47	0.59	47	60647	40	3	29	8	53
TMR_00584	tmRNA links to Rfam database...	0.71	0.65	0.79	63	60995	25	3	14	8	34
TMR_00586	tmRNA links to Rfam database...	0.61	0.52	0.72	50	61006	26	5	14	7	47
TMR_00616	tmRNA links to Rfam database...	0.66	0.57	0.77	56	67088	23	3	14	6	43
TMR_00699	tmRNA links to Rfam database...	0.54	0.38	0.76	39	67110	13	3	9	1	63
TMR_00702	tmRNA links to Rfam database...	0.42	0.32	0.56	32	67104	28	3	22	3	68
TMR_00703	tmRNA links to Rfam database...	0.56	0.41	0.76	41	67474	18	3	10	5	58

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Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

Total Base Pair Counts
Total TP	1326
Total TN	4279490
Total FP	5547
Total FP CONTRA	682
Total FP INCONS	4579
Total FP COMP	286
Total FN	6123

Total Scores
MCC	0.188
Average MCC ± 95% Confidence Intervals	0.177 ± 0.030
Sensitivity	0.178
Positive Predictive Value	0.201
Nr of predictions	78

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2. Individual counts for Vsfold5 [ download as .csv ]

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
ASE_00064	RNaseP_bact_a links to Rfam database...	0.39	0.37	0.40	33	45369	55	1	48	6	56
ASE_00090	RNaseP_bact_a links to Rfam database...	0.50	0.50	0.52	50	55514	50	4	43	3	51
ASE_00135	RNaseP_bact_a links to Rfam database...	0.35	0.32	0.38	35	63097	63	3	55	5	74
ASE_00153	RNaseP_nuc links to Rfam database...	0.28	0.32	0.26	23	57540	91	12	55	24	50
ASE_00215	RNaseP_bact_a links to Rfam database...	0.49	0.43	0.57	43	48440	37	6	27	4	56
ASE_00305	RNaseP_bact_b links to Rfam database...	0.63	0.62	0.63	53	54531	36	10	21	5	32
ASE_00328	RNaseP_bact_b links to Rfam database...	0.37	0.35	0.39	39	72671	67	4	57	6	73
ASE_00361	RNaseP_bact_a links to Rfam database...	0.35	0.32	0.38	41	75357	68	9	59	0	86
ASE_00427	RNaseP_nuc links to Rfam database...	0.00	0.00	0.00	0	40688	82	15	52	15	46
ASE_00441	RNaseP_bact_a links to Rfam database...	0.33	0.30	0.35	34	64164	63	6	57	0	78
SRP_00006	Metazoa_SRP links to Rfam database...	0.11	0.10	0.12	10	45670	77	5	68	4	91
SRP_00011	Plant_SRP links to Rfam database...	0.05	0.05	0.06	5	46277	78	8	70	0	99
SRP_00015	Plant_SRP links to Rfam database...	0.15	0.14	0.17	14	46276	72	10	60	2	85
SRP_00024	Bacteria_large_SRP links to Rfam database...	0.13	0.13	0.14	11	37597	67	9	58	0	76
SRP_00026	Bacteria_large_SRP links to Rfam database...	0.06	0.06	0.07	5	36783	68	10	58	0	83
SRP_00030	Bacteria_large_SRP links to Rfam database...	0.02	0.02	0.03	2	36783	71	2	69	0	86
SRP_00031	Bacteria_large_SRP links to Rfam database...	0.08	0.08	0.09	7	36240	68	6	62	0	82
SRP_00037	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	36510	75	6	69	0	87
SRP_00050	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	44762	88	9	79	0	99
SRP_00066	Metazoa_SRP links to Rfam database...	0.08	0.08	0.09	8	45363	80	5	75	0	92
SRP_00086	Metazoa_SRP links to Rfam database...	0.19	0.18	0.20	18	44161	76	4	70	2	82
SRP_00088	Bacteria_large_SRP links to Rfam database...	0.06	0.06	0.06	5	34110	76	6	70	0	84
SRP_00089	Bacteria_large_SRP links to Rfam database...	0.11	0.11	0.12	10	35693	75	8	67	0	80
SRP_00090	Bacteria_large_SRP links to Rfam database...	0.12	0.11	0.13	10	35434	67	3	64	0	80
SRP_00102	Metazoa_SRP links to Rfam database...	0.10	0.10	0.11	10	44464	78	4	73	1	91
SRP_00103	Metazoa_SRP links to Rfam database...	0.15	0.14	0.16	14	45362	75	7	68	0	88
SRP_00152	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	45753	0	0	0	0	103
SRP_00171	Metazoa_SRP links to Rfam database...	0.00	0.00	0.00	0	45365	86	12	74	0	88
SRP_00178	Plant_SRP links to Rfam database...	0.07	0.07	0.08	7	45668	78	9	69	0	95
SRP_00179	Plant_SRP links to Rfam database...	0.00	0.00	0.00	0	46056	0	0	0	0	105
SRP_00181	Plant_SRP links to Rfam database...	0.07	0.07	0.08	7	45963	86	6	80	0	95
SRP_00182	Plant_SRP links to Rfam database...	0.16	0.16	0.17	16	45964	76	7	69	0	85
SRP_00188	Plant_SRP links to Rfam database...	0.08	0.09	0.08	7	31041	77	13	64	0	72
SRP_00228	Metazoa_SRP links to Rfam database...	0.08	0.07	0.08	7	45367	79	8	69	2	88
SRP_00234	Bacteria_large_SRP links to Rfam database...	0.05	0.05	0.05	4	36240	72	5	66	1	82
SRP_00308	Bacteria_large_SRP links to Rfam database...	0.29	0.27	0.32	24	36239	52	11	41	0	64
SRP_00317	Metazoa_SRP links to Rfam database...	0.10	0.09	0.11	9	45065	78	2	74	2	89
SRP_00335	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35175	86	35	35	16	39
SRP_00337	Bacteria_large_SRP links to Rfam database...	0.00	0.00	0.00	0	35438	74	5	68	1	91
SRP_00347	Metazoa_SRP links to Rfam database...	0.20	0.19	0.21	18	46578	71	7	62	2	78
SRP_00368	Metazoa_SRP links to Rfam database...	0.06	0.06	0.07	6	43872	78	11	67	0	92
TMR_00017	tmRNA links to Rfam database...	0.29	0.28	0.29	29	67062	74	8	62	4	73
TMR_00018	tmRNA links to Rfam database...	0.27	0.27	0.27	25	64528	72	10	57	5	67
TMR_00042	tmRNA links to Rfam database...	0.15	0.15	0.15	15	62738	86	16	66	4	83
TMR_00046	tmRNA links to Rfam database...	0.00	0.00	0.00	0	62835	0	0	0	0	96
TMR_00048	tmRNA links to Rfam database...	0.25	0.26	0.25	25	64879	82	15	61	6	70
TMR_00080	tmRNA links to Rfam database...	0.35	0.38	0.32	36	70388	76	16	60	0	60
TMR_00082	tmRNA links to Rfam database...	0.39	0.40	0.38	38	67796	62	11	51	0	58
TMR_00123	tmRNA links to Rfam database...	0.28	0.28	0.29	28	66332	75	9	61	5	73
TMR_00137	tmRNA links to Rfam database...	0.15	0.15	0.15	13	60990	82	6	66	10	76
TMR_00142	tmRNA links to Rfam database...	0.16	0.17	0.15	17	70764	98	20	75	3	85
TMR_00207	tmRNA links to Rfam database...	0.16	0.17	0.17	17	72287	91	9	77	5	86
TMR_00257	tmRNA links to Rfam database...	0.17	0.16	0.18	16	67070	80	6	69	5	82
TMR_00271	tmRNA links to Rfam database...	0.17	0.18	0.17	16	64166	88	15	64	9	75
TMR_00332	tmRNA links to Rfam database...	0.16	0.15	0.16	15	67068	83	6	72	5	84
TMR_00366	tmRNA links to Rfam database...	0.26	0.26	0.26	26	67796	80	13	61	6	74
TMR_00378	tmRNA links to Rfam database...	0.11	0.11	0.10	11	67790	100	15	80	5	86
TMR_00404	tmRNA links to Rfam database...	0.26	0.27	0.25	25	67428	83	15	60	8	67
TMR_00427	tmRNA links to Rfam database...	0.00	0.00	0.00	0	67528	0	0	0	0	97
TMR_00443	tmRNA links to Rfam database...	0.15	0.14	0.16	15	67066	84	8	72	4	89
TMR_00451	tmRNA links to Rfam database...	0.37	0.38	0.36	34	63451	65	16	45	4	55
TMR_00458	tmRNA links to Rfam database...	0.14	0.14	0.14	13	63451	89	13	69	7	80
TMR_00469	tmRNA links to Rfam database...	0.12	0.12	0.12	12	64521	92	8	79	5	88
TMR_00472	tmRNA links to Rfam database...	0.27	0.28	0.27	27	64520	80	4	69	7	70
TMR_00519	tmRNA links to Rfam database...	0.12	0.12	0.13	11	63107	82	11	61	10	84
TMR_00520	tmRNA links to Rfam database...	0.26	0.27	0.25	27	63084	79	13	66	0	72
TMR_00522	tmRNA links to Rfam database...	0.17	0.16	0.17	16	63096	83	17	61	5	81
TMR_00528	tmRNA links to Rfam database...	0.31	0.31	0.31	30	63092	73	16	52	5	67
TMR_00540	tmRNA links to Rfam database...	0.17	0.16	0.17	17	73438	89	10	71	8	87
TMR_00568	tmRNA links to Rfam database...	0.16	0.15	0.17	15	60636	81	3	72	6	84
TMR_00571	tmRNA links to Rfam database...	0.00	0.00	0.00	0	60726	0	0	0	0	99
TMR_00580	tmRNA links to Rfam database...	0.23	0.23	0.24	23	60629	80	8	66	6	77
TMR_00584	tmRNA links to Rfam database...	0.18	0.19	0.18	18	60977	85	11	69	5	79
TMR_00586	tmRNA links to Rfam database...	0.16	0.15	0.16	15	60984	85	11	65	9	82
TMR_00616	tmRNA links to Rfam database...	0.32	0.31	0.32	31	67064	72	11	55	6	68
TMR_00699	tmRNA links to Rfam database...	0.28	0.28	0.27	29	67054	82	14	64	4	73
TMR_00702	tmRNA links to Rfam database...	0.26	0.25	0.28	25	67072	71	8	56	7	75
TMR_00703	tmRNA links to Rfam database...	0.33	0.31	0.34	31	67437	67	7	53	7	68

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Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.

Table of contents:

Overview

Performance plots

Performance of RNASampler(20) - scored higher in this pairwise comparison

1. Total counts & total scores for RNASampler(20)

2. Individual counts for RNASampler(20) [ download as .csv ]

Performance of Vsfold5 - scored lower in this pairwise comparison

1. Total counts & total scores for Vsfold5

2. Individual counts for Vsfold5 [ download as .csv ]