CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNASampler(seed)		Afold
MCC	0.773	>	0.629
Average MCC ± 95% Confidence Intervals	0.766 ± 0.100	>	0.614 ± 0.154
Sensitivity	0.652	>	0.638
Positive Predictive Value	0.917	>	0.621
Total TP	411	>	402
Total TN	391849	>	391650
Total FP	104	<	407
Total FP CONTRA	9	<	78
Total FP INCONS	28	<	167
Total FP COMP	67	<	162
Total FN	219	<	228
P-value	9.9460272886e-09

Comparison of performance of RNASampler(seed) and Afold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and Afold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and Afold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and Afold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and Afold).

Total Scores
MCC	0.773
Average MCC ± 95% Confidence Intervals	0.766 ± 0.100
Sensitivity	0.652
Positive Predictive Value	0.917
Nr of predictions	11

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.44	0.36	0.54	14	21295	18	7	5	6	25
RFA_00620	Telomerase-cil links to Rfam database...	0.52	0.44	0.63	17	21918	15	2	8	5	22
RFA_00626	rne5 links to Rfam database...	0.80	0.64	1.00	56	56560	5	0	0	5	31
RFA_00627	rne5 links to Rfam database...	0.77	0.63	0.93	55	56894	8	0	4	4	32
RFA_00628	rne5 links to Rfam database...	0.78	0.64	0.95	55	57233	12	0	3	9	31
RFA_00630	rne5 links to Rfam database...	0.77	0.66	0.90	57	56890	15	0	6	9	30
RFA_00814	R2_retro_el links to Rfam database...	0.87	0.78	0.97	32	25167	6	0	1	5	9
RFA_00815	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	24499	8	0	0	8	9
RFA_00816	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	23188	6	0	1	5	10
RFA_00818	R2_retro_el links to Rfam database...	0.86	0.73	1.00	30	20271	6	0	0	6	11
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	27934	5	0	0	5	9

Total Scores
MCC	0.629
Average MCC ± 95% Confidence Intervals	0.614 ± 0.154
Sensitivity	0.638
Positive Predictive Value	0.621
Nr of predictions	11

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.67	0.67	0.68	26	21283	26	7	5	14	13
RFA_00620	Telomerase-cil links to Rfam database...	0.64	0.62	0.67	24	21909	26	3	9	14	15
RFA_00626	rne5 links to Rfam database...	0.89	0.86	0.93	75	56535	31	2	4	25	12
RFA_00627	rne5 links to Rfam database...	0.48	0.47	0.48	41	56868	50	10	34	6	46
RFA_00628	rne5 links to Rfam database...	0.83	0.80	0.85	69	57210	38	1	11	26	17
RFA_00630	rne5 links to Rfam database...	0.60	0.60	0.60	52	56866	46	8	27	11	35
RFA_00814	R2_retro_el links to Rfam database...	0.35	0.37	0.33	15	25155	42	7	23	12	26
RFA_00815	R2_retro_el links to Rfam database...	0.56	0.61	0.51	25	24482	35	8	16	11	16
RFA_00816	R2_retro_el links to Rfam database...	0.59	0.66	0.53	27	23169	33	13	11	9	14
RFA_00818	R2_retro_el links to Rfam database...	0.19	0.22	0.17	9	20247	48	19	26	3	32
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	32	0	1	31	2

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.