CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNASampler(seed)		CentroidFold
MCC	0.779	>	0.719
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092	>	0.661 ± 0.140
Sensitivity	0.659	<	0.665
Positive Predictive Value	0.921	>	0.778
Total TP	442	<	446
Total TN	413762	>	413669
Total FP	105	<	246
Total FP CONTRA	9	<	36
Total FP INCONS	29	<	91
Total FP COMP	67	<	119
Total FN	229	>	225
P-value	2.00627773251e-08

Comparison of performance of RNASampler(seed) and CentroidFold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and CentroidFold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and CentroidFold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and CentroidFold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and CentroidFold).

Total Scores
MCC	0.779
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092
Sensitivity	0.659
Positive Predictive Value	0.921
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.44	0.36	0.54	14	21295	18	7	5	6	25
RFA_00620	Telomerase-cil links to Rfam database...	0.52	0.44	0.63	17	21918	15	2	8	5	22
RFA_00626	rne5 links to Rfam database...	0.80	0.64	1.00	56	56560	5	0	0	5	31
RFA_00627	rne5 links to Rfam database...	0.77	0.63	0.93	55	56894	8	0	4	4	32
RFA_00628	rne5 links to Rfam database...	0.78	0.64	0.95	55	57233	12	0	3	9	31
RFA_00630	rne5 links to Rfam database...	0.77	0.66	0.90	57	56890	15	0	6	9	30
RFA_00814	R2_retro_el links to Rfam database...	0.87	0.78	0.97	32	25167	6	0	1	5	9
RFA_00815	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	24499	8	0	0	8	9
RFA_00816	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	23188	6	0	1	5	10
RFA_00817	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	21913	1	0	1	0	10
RFA_00818	R2_retro_el links to Rfam database...	0.86	0.73	1.00	30	20271	6	0	0	6	11
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	27934	5	0	0	5	9

Total Scores
MCC	0.719
Average MCC ± 95% Confidence Intervals	0.661 ± 0.140
Sensitivity	0.665
Positive Predictive Value	0.778
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.57	0.51	0.63	20	21289	21	7	5	9	19
RFA_00620	Telomerase-cil links to Rfam database...	0.68	0.56	0.81	22	21918	20	0	5	15	17
RFA_00626	rne5 links to Rfam database...	0.90	0.86	0.95	75	56537	20	0	4	16	12
RFA_00627	rne5 links to Rfam database...	0.87	0.82	0.93	71	56877	18	0	5	13	16
RFA_00628	rne5 links to Rfam database...	0.90	0.86	0.94	74	57212	20	0	5	15	12
RFA_00630	rne5 links to Rfam database...	0.80	0.76	0.85	66	56875	25	0	12	13	21
RFA_00814	R2_retro_el links to Rfam database...	0.70	0.51	0.95	21	25178	6	0	1	5	20
RFA_00815	R2_retro_el links to Rfam database...	0.61	0.61	0.61	25	24490	22	1	15	6	16
RFA_00816	R2_retro_el links to Rfam database...	0.75	0.73	0.77	30	23181	14	8	1	5	11
RFA_00817	R2_retro_el links to Rfam database...	0.13	0.12	0.14	5	21909	31	9	22	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.54	0.54	0.54	22	20260	26	11	8	7	19
RFA_00819	R2_retro_el links to Rfam database...	0.49	0.37	0.65	15	27943	23	0	8	15	26

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.