CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNASampler(seed)		Contrafold
MCC	0.779	>	0.706
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092	>	0.659 ± 0.145
Sensitivity	0.659	<	0.703
Positive Predictive Value	0.921	>	0.709
Total TP	442	<	472
Total TN	413762	>	413576
Total FP	105	<	367
Total FP CONTRA	9	<	54
Total FP INCONS	29	<	140
Total FP COMP	67	<	173
Total FN	229	>	199
P-value	1.4651262096e-08

Comparison of performance of RNASampler(seed) and Contrafold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and Contrafold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and Contrafold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and Contrafold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and Contrafold).

Total Scores
MCC	0.779
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092
Sensitivity	0.659
Positive Predictive Value	0.921
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.44	0.36	0.54	14	21295	18	7	5	6	25
RFA_00620	Telomerase-cil links to Rfam database...	0.52	0.44	0.63	17	21918	15	2	8	5	22
RFA_00626	rne5 links to Rfam database...	0.80	0.64	1.00	56	56560	5	0	0	5	31
RFA_00627	rne5 links to Rfam database...	0.77	0.63	0.93	55	56894	8	0	4	4	32
RFA_00628	rne5 links to Rfam database...	0.78	0.64	0.95	55	57233	12	0	3	9	31
RFA_00630	rne5 links to Rfam database...	0.77	0.66	0.90	57	56890	15	0	6	9	30
RFA_00814	R2_retro_el links to Rfam database...	0.87	0.78	0.97	32	25167	6	0	1	5	9
RFA_00815	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	24499	8	0	0	8	9
RFA_00816	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	23188	6	0	1	5	10
RFA_00817	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	21913	1	0	1	0	10
RFA_00818	R2_retro_el links to Rfam database...	0.86	0.73	1.00	30	20271	6	0	0	6	11
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	27934	5	0	0	5	9

Total Scores
MCC	0.706
Average MCC ± 95% Confidence Intervals	0.659 ± 0.145
Sensitivity	0.703
Positive Predictive Value	0.709
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.53	0.51	0.54	20	21284	25	10	7	8	19
RFA_00620	Telomerase-cil links to Rfam database...	0.71	0.64	0.78	25	21913	29	0	7	22	14
RFA_00626	rne5 links to Rfam database...	0.91	0.87	0.94	76	56535	26	1	4	21	11
RFA_00627	rne5 links to Rfam database...	0.86	0.83	0.89	72	56872	28	0	9	19	15
RFA_00628	rne5 links to Rfam database...	0.91	0.88	0.94	76	57210	25	0	5	20	10
RFA_00630	rne5 links to Rfam database...	0.77	0.77	0.77	67	56866	34	6	14	14	20
RFA_00814	R2_retro_el links to Rfam database...	0.79	0.78	0.80	32	25160	19	1	7	11	9
RFA_00815	R2_retro_el links to Rfam database...	0.59	0.61	0.57	25	24487	35	2	17	16	16
RFA_00816	R2_retro_el links to Rfam database...	0.72	0.73	0.71	30	23178	20	8	4	8	11
RFA_00817	R2_retro_el links to Rfam database...	0.11	0.12	0.10	5	21893	47	12	35	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.57	0.61	0.53	25	20254	32	11	11	10	16
RFA_00819	R2_retro_el links to Rfam database...	0.46	0.46	0.45	19	27924	47	3	20	24	22

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.