CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNASampler(seed)		Fold
MCC	0.779	>	0.631
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092	>	0.601 ± 0.128
Sensitivity	0.659	>	0.648
Positive Predictive Value	0.921	>	0.614
Total TP	442	>	435
Total TN	413762	>	413534
Total FP	105	<	465
Total FP CONTRA	9	<	84
Total FP INCONS	29	<	189
Total FP COMP	67	<	192
Total FN	229	<	236
P-value	1.47941000302e-08

Comparison of performance of RNASampler(seed) and Fold. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and Fold).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and Fold).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and Fold. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and Fold).

Total Scores
MCC	0.779
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092
Sensitivity	0.659
Positive Predictive Value	0.921
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.44	0.36	0.54	14	21295	18	7	5	6	25
RFA_00620	Telomerase-cil links to Rfam database...	0.52	0.44	0.63	17	21918	15	2	8	5	22
RFA_00626	rne5 links to Rfam database...	0.80	0.64	1.00	56	56560	5	0	0	5	31
RFA_00627	rne5 links to Rfam database...	0.77	0.63	0.93	55	56894	8	0	4	4	32
RFA_00628	rne5 links to Rfam database...	0.78	0.64	0.95	55	57233	12	0	3	9	31
RFA_00630	rne5 links to Rfam database...	0.77	0.66	0.90	57	56890	15	0	6	9	30
RFA_00814	R2_retro_el links to Rfam database...	0.87	0.78	0.97	32	25167	6	0	1	5	9
RFA_00815	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	24499	8	0	0	8	9
RFA_00816	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	23188	6	0	1	5	10
RFA_00817	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	21913	1	0	1	0	10
RFA_00818	R2_retro_el links to Rfam database...	0.86	0.73	1.00	30	20271	6	0	0	6	11
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	27934	5	0	0	5	9

Total Scores
MCC	0.631
Average MCC ± 95% Confidence Intervals	0.601 ± 0.128
Sensitivity	0.648
Positive Predictive Value	0.614
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.68	0.67	0.70	26	21284	27	7	4	16	13
RFA_00620	Telomerase-cil links to Rfam database...	0.47	0.49	0.45	19	21903	36	7	16	13	20
RFA_00626	rne5 links to Rfam database...	0.86	0.82	0.90	71	56537	35	2	6	27	16
RFA_00627	rne5 links to Rfam database...	0.68	0.67	0.69	58	56869	42	7	19	16	29
RFA_00628	rne5 links to Rfam database...	0.87	0.84	0.90	72	57211	30	0	8	22	14
RFA_00630	rne5 links to Rfam database...	0.62	0.63	0.61	55	56863	52	9	26	17	32
RFA_00814	R2_retro_el links to Rfam database...	0.22	0.24	0.19	10	25148	51	11	31	9	31
RFA_00815	R2_retro_el links to Rfam database...	0.57	0.61	0.54	25	24485	37	4	17	16	16
RFA_00816	R2_retro_el links to Rfam database...	0.61	0.66	0.56	27	23172	33	13	8	12	14
RFA_00817	R2_retro_el links to Rfam database...	0.35	0.41	0.30	17	21889	43	11	28	4	24
RFA_00818	R2_retro_el links to Rfam database...	0.46	0.54	0.40	22	20246	38	13	20	5	19
RFA_00819	R2_retro_el links to Rfam database...	0.83	0.80	0.85	33	27927	41	0	6	35	8

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.