CompaRNA - on-line benchmarks of RNA structure prediction methods

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Metric	RNASampler(seed)		MaxExpect
MCC	0.779	>	0.637
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092	>	0.605 ± 0.166
Sensitivity	0.659	>	0.654
Positive Predictive Value	0.921	>	0.622
Total TP	442	>	439
Total TN	413762	>	413536
Total FP	105	<	413
Total FP CONTRA	9	<	81
Total FP INCONS	29	<	186
Total FP COMP	67	<	146
Total FN	229	<	232
P-value	8.44035332136e-09

Comparison of performance of RNASampler(seed) and MaxExpect. Positive Predictive Value (PPV) is plotted against sensitivity. Each dot represents a single test of each method. See tables below for raw data (individual counts for RNASampler(seed) and MaxExpect).
Average Matthews Correlation Coefficients (MCC) with 95% confidence intervals (CIs) were plotted for different RNA families, for which at least 3 members were present in the benchmarking dataset. 'n' denotes the number of MCCs used to calculate the average and CI. See tables below for raw data (individual counts for RNASampler(seed) and MaxExpect).
Comparison of average Matthews Correlation Coefficients (MCCs) for RNASampler(seed) and MaxExpect. The whiskers correspond to 95% confidence intervals (CIs). 'n' denotes the number of MCCs used to calculate average MCCs and CIs. See tables below for raw data (individual counts for RNASampler(seed) and MaxExpect).

Total Scores
MCC	0.779
Average MCC ± 95% Confidence Intervals	0.774 ± 0.092
Sensitivity	0.659
Positive Predictive Value	0.921
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.44	0.36	0.54	14	21295	18	7	5	6	25
RFA_00620	Telomerase-cil links to Rfam database...	0.52	0.44	0.63	17	21918	15	2	8	5	22
RFA_00626	rne5 links to Rfam database...	0.80	0.64	1.00	56	56560	5	0	0	5	31
RFA_00627	rne5 links to Rfam database...	0.77	0.63	0.93	55	56894	8	0	4	4	32
RFA_00628	rne5 links to Rfam database...	0.78	0.64	0.95	55	57233	12	0	3	9	31
RFA_00630	rne5 links to Rfam database...	0.77	0.66	0.90	57	56890	15	0	6	9	30
RFA_00814	R2_retro_el links to Rfam database...	0.87	0.78	0.97	32	25167	6	0	1	5	9
RFA_00815	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	24499	8	0	0	8	9
RFA_00816	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	23188	6	0	1	5	10
RFA_00817	R2_retro_el links to Rfam database...	0.86	0.76	0.97	31	21913	1	0	1	0	10
RFA_00818	R2_retro_el links to Rfam database...	0.86	0.73	1.00	30	20271	6	0	0	6	11
RFA_00819	R2_retro_el links to Rfam database...	0.88	0.78	1.00	32	27934	5	0	0	5	9

Total Scores
MCC	0.637
Average MCC ± 95% Confidence Intervals	0.605 ± 0.166
Sensitivity	0.654
Positive Predictive Value	0.622
Nr of predictions	12

RNA Chain	Rfam family	MCC	SENS	PPV	TP	TN	FP	FP CONTRA	FP INCONS	FP COMP	FN
RFA_00606	Telomerase-cil links to Rfam database...	0.68	0.67	0.70	26	21284	24	7	4	13	13
RFA_00620	Telomerase-cil links to Rfam database...	0.44	0.49	0.40	19	21897	42	7	22	13	20
RFA_00626	rne5 links to Rfam database...	0.88	0.84	0.92	73	56537	23	2	4	17	14
RFA_00627	rne5 links to Rfam database...	0.71	0.68	0.74	59	56873	37	5	16	16	28
RFA_00628	rne5 links to Rfam database...	0.91	0.88	0.94	76	57210	25	0	5	20	10
RFA_00630	rne5 links to Rfam database...	0.66	0.66	0.66	57	56867	44	7	22	15	30
RFA_00814	R2_retro_el links to Rfam database...	0.24	0.27	0.22	11	25149	45	9	31	5	30
RFA_00815	R2_retro_el links to Rfam database...	0.57	0.61	0.54	25	24485	29	4	17	8	16
RFA_00816	R2_retro_el links to Rfam database...	0.63	0.66	0.60	27	23175	24	11	7	6	14
RFA_00817	R2_retro_el links to Rfam database...	0.10	0.12	0.08	5	21883	57	17	40	0	36
RFA_00818	R2_retro_el links to Rfam database...	0.48	0.54	0.43	22	20250	30	12	17	1	19
RFA_00819	R2_retro_el links to Rfam database...	0.96	0.95	0.98	39	27926	33	0	1	32	2

Matthews Correlation Coeffient, Sensitivity and Positive Predictive Value have been calculated based on the paper by Gardener & Giegerich, 2004.